PMID- 36117708
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220920
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 13
DP  - 2022
TI  - Effects of supplemental tannic acid on growth performance, gut health, 
      microbiota, and fat accumulation and optimal dosages of tannic acid in broilers.
PG  - 912797
LID - 10.3389/fphys.2022.912797 [doi]
LID - 912797
AB  - This study was conducted to investigate the effects of different dosages of 
      tannic acid (TA) on growth performance, nutrient digestibility, gut health, 
      immune system, oxidative status, microbial composition, volatile fatty acids 
      (VFA), bone mineral density, and fat digestion and accumulation in broilers and 
      to find optimal dosages of TA for efficient growth and gut health in broilers. A 
      total of 320 male Cobb500 broilers were randomly distributed to 4 treatments with 
      8 replicates including 1) tannic acid 0 (TA0): basal diet without TA; 2) tannic 
      acid 0.5 (TA0.5): basal diet with 0.5 g/kg TA; 3) tannic acid 1.5 (TA1.5); and 4) 
      tannic acid 2.5 (TA2.5). Supplemental TA at levels greater than 972 mg/kg tended 
      to reduce BW on D 21 (p = 0.05). The TA2.5 had significantly lower apparent ileal 
      digestibility (AID) of crude protein compared to the TA0 group. The AID of ether 
      extract tended to be reduced by TA at levels greater than 525 mg/kg (p = 0.08). 
      The jejunal lipase activities tended to be reduced by TA at levels less than 
      595.3 mg/kg (p = 0.09). TA linearly decreased goblet cell density in the crypts 
      of the jejunum (p < 0.05) and reduced mRNA expression of mucin two at levels less 
      than 784.9 mg/kg and zonula occludens two at levels less than 892.6 mg/kg (p < 
      0.05). The TA0.5 group had higher activities of liver superoxide dismutase 
      compared to the TA0 group (p < 0.05). Bone mineral density and contents tended to 
      be linearly decreased by TA (p = 0.05), and the ratio of lean to fat was linearly 
      decreased (p < 0.01). Total cecal VFA production tended to be linearly reduced by 
      TA at levels greater than 850.9 mg/kg (p = 0.07). Supplemental TA tended to 
      increase the relative abundance of the phylum Bacteroidetes (p = 0.1) and 
      decrease the relative abundance of the phylum Proteobacteria (p = 0.1). The 
      relative abundance of the family Rikenellaceae was the lowest at 500 mg/kg TA, 
      and the relative abundance of the family Bacillaceae was the highest at 
      1,045 mg/kg TA. Collectively, these results indicate that the optimum level of 
      supplemental TA would range between 500 and 900 mg/kg; this range of TA 
      supplementation would improve gut health without negatively affecting growth 
      performance in broilers under antibiotic-free conditions.
CI  - Copyright (c) 2022 Choi, Yadav, Wang, Lorentz, Lourenco, Callaway and Kim.
FAU - Choi, Janghan
AU  - Choi J
AD  - Department of Poultry Science, University of Georgia, Athens, GA, United States.
FAU - Yadav, Sudhir
AU  - Yadav S
AD  - Department of Poultry Science, University of Georgia, Athens, GA, United States.
FAU - Wang, Jinquan
AU  - Wang J
AD  - Department of Poultry Science, University of Georgia, Athens, GA, United States.
FAU - Lorentz, Benjamin J
AU  - Lorentz BJ
AD  - Department of Poultry Science, University of Georgia, Athens, GA, United States.
FAU - Lourenco, Jeferson M
AU  - Lourenco JM
AD  - Department of Animal and Dairy Science, University of Georgia, Athens, GA, United 
      States.
FAU - Callaway, Todd R
AU  - Callaway TR
AD  - Department of Animal and Dairy Science, University of Georgia, Athens, GA, United 
      States.
FAU - Kim, Woo Kyun
AU  - Kim WK
AD  - Department of Poultry Science, University of Georgia, Athens, GA, United States.
LA  - eng
PT  - Journal Article
DEP - 20220902
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC9478478
OTO - NOTNLM
OT  - apparent ileal digestibility
OT  - chickens
OT  - fat accumulation
OT  - gut health
OT  - microbiota
OT  - tannic acid
OT  - volatile fatty acids
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/20 06:00
MHDA- 2022/09/20 06:01
PMCR- 2022/09/02
CRDT- 2022/09/19 03:58
PHST- 2022/04/04 00:00 [received]
PHST- 2022/06/27 00:00 [accepted]
PHST- 2022/09/19 03:58 [entrez]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2022/09/20 06:01 [medline]
PHST- 2022/09/02 00:00 [pmc-release]
AID - 912797 [pii]
AID - 10.3389/fphys.2022.912797 [doi]
PST - epublish
SO  - Front Physiol. 2022 Sep 2;13:912797. doi: 10.3389/fphys.2022.912797. eCollection 
      2022.