PMID- 36117766
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220920
IS  - 2589-3610 (Electronic)
IS  - 1674-6384 (Print)
IS  - 1674-6384 (Linking)
VI  - 13
IP  - 1
DP  - 2021 Jan
TI  - Challenges and strategies in progress of drug delivery system for traditional 
      Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Danshen).
PG  - 78-89
LID - 10.1016/j.chmed.2020.08.001 [doi]
AB  - Traditional Chinese medicines (TCMs), with a history of thousands of years, are 
      widely used clinically with effective treatment. However, the drug delivery 
      systems (DDSs) for TCMs remains major challenges due to the characteristics of 
      multi-components including alkaloids, flavones, anthraquinones, glycosides, 
      proteins, volatile oils and other types. Therefore, the novel preparations and 
      technology of modern pharmaceutics is introduced to improve TCM therapeutic 
      effects due to instability and low bioavailability of active ingredients. Salviae 
      Miltiorrhizae Radix et Rhizoma, the radix and rhizomes of Salvia miltiorrhiza 
      Bunge (Danshen in Chinese), is a well known Chinese herbal medicine for 
      protecting the cardiovascular system, with active ingredients mainly including 
      lipophilic tanshinones and hydrophilic salvianolic acids. In this review, this 
      drug is taken as an example to present challenges and strategies in progress of 
      DDSs for TCMs. This review would also summary the characteristics of active 
      ingredients in it including physicochemical properties and pharmacological 
      effects. The purpose of this review is to provide inspirations and ideas for the 
      DDSs designed from TCMs by summarizing the advances on DDSs for both single- and 
      multi-component from Danshen.
CI  - (c) 2020 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.
FAU - Wang, Ruo-Ning
AU  - Wang RN
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, 
      China.
AD  - Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 
      210046, China.
FAU - Zhao, Hua-Cong
AU  - Zhao HC
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, 
      China.
AD  - Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 
      210046, China.
FAU - Huang, Jian-Yu
AU  - Huang JY
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, 
      China.
AD  - Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 
      210046, China.
FAU - Wang, Hong-Lan
AU  - Wang HL
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, 
      China.
AD  - Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 
      210046, China.
FAU - Li, Jun-Song
AU  - Li JS
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, 
      China.
AD  - Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 
      210046, China.
FAU - Lu, Yin
AU  - Lu Y
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, 
      China.
AD  - Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia 
      Medica, Nanjing 210046, China.
FAU - Di, Liu-Qing
AU  - Di LQ
AD  - School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, 
      China.
AD  - Jiangsu Engineering Research Center for Efficient Delivery System of TCM, Nanjing 
      210046, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201114
PL  - Singapore
TA  - Chin Herb Med
JT  - Chinese herbal medicines
JID - 101556727
PMC - PMC9476708
OTO - NOTNLM
OT  - Salvia miltiorrhiza Bunge
OT  - Salviae Miltiorrhizae Radix et Rhizoma
OT  - active ingredients
OT  - challenges and strategies
OT  - drug delivery systems
OT  - traditional Chinese medicines
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/11/14 00:00
MHDA- 2020/11/14 00:01
PMCR- 2020/11/14
CRDT- 2022/09/19 03:59
PHST- 2020/04/27 00:00 [received]
PHST- 2020/07/14 00:00 [revised]
PHST- 2020/08/18 00:00 [accepted]
PHST- 2022/09/19 03:59 [entrez]
PHST- 2020/11/14 00:00 [pubmed]
PHST- 2020/11/14 00:01 [medline]
PHST- 2020/11/14 00:00 [pmc-release]
AID - S1674-6384(20)30114-3 [pii]
AID - 10.1016/j.chmed.2020.08.001 [doi]
PST - epublish
SO  - Chin Herb Med. 2020 Nov 14;13(1):78-89. doi: 10.1016/j.chmed.2020.08.001. 
      eCollection 2021 Jan.