PMID- 36118003
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220920
IS  - 2589-3610 (Electronic)
IS  - 1674-6384 (Print)
IS  - 1674-6384 (Linking)
VI  - 14
IP  - 3
DP  - 2022 Jul
TI  - Mongolian medicine in treating type 2 diabetes mellitus combined with 
      nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-kappaB pathway 
      activation.
PG  - 367-375
LID - 10.1016/j.chmed.2022.06.003 [doi]
AB  - Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are 
      the most problematic metabolic diseases in the world. NAFLD encompasses a 
      spectrum of severity, ranging from simple steatosis to non-alcoholic 
      steatohepatitis (NASH) and fibrosis, increasing the risk of cirrhosis and 
      hepatocellular carcinoma. Importantly, NAFLD is closely linked to obesity and 
      tightly interrelated with insulin resistance and T2DM. T2DM and NAFLD 
      (T2DM-NAFLD) are called as the Xike Rixijing Disease and Tonglaga Indigestion 
      Disease respectively, in Mongolian medicine. Xike Rixijing Disease maybe develop 
      into Tonglaga Indigestion Disease. Forturnately many Mongolian medicines show 
      efficient treatment of T2DM-NAFLD, such as Agriophyllum squarrosum, Haliyasu 
      (dried powder of camel placenta), Digeda-4 (herbs of Lomatogonium carinthiacum, 
      rhizomata of Coptis chinensis, ripe fruits of Gardenia jasminoides, herbs of 
      Dianthus superbus), Guangmingyan Siwei Decoction Powder (Halite, ripe fruits of 
      Terminalia chebula, rhizomata of Zingiber officinale, fruit clusters of Piper 
      longum), Tonglaga-5 (ripe fruits of Punica granatum, barks of Cinnamomum cassia, 
      ripe fruits of Amomum kravanh, fruit clusters of Piper longum, flowers of 
      Carthamus tinctorius), Tegexidegeqi (rhizomata of Inula helenium, ripe fruits of 
      Gardenia jasminoides, rhizomata of Platycodon grandiflorum, rhizomata of Coptis 
      chinensis, heartwood of Caesalpinia sappan), Ligan Shiliu Bawei San (ripe fruits 
      of Punica granatum, barks of Cinnamomum cassia, ripe fruits of Amomum kravanh, 
      fruit clusters of Piper longum, flowers of Carthamus tinctorius, ripe fruits of 
      Amomum tsao-ko, rhizomata of Zingiber officinale), etc. Principles of Mongolian 
      medicine in treating diseases: by balancing "three essences or roots" and "seven 
      elements", strengthening liver and kidney function, transporting nutrients to 
      enhance physical strength and disease resistance, and combined with drugs for 
      comprehensive conditioning treatment. However, their molecular mechanisms remain 
      unclear. In this review, we prospect that Mongolian medicines might be a 
      promising treatment for T2DM-NAFLD by activating P2X7R/NLRP3/NF-kappaB inflammatory 
      pathway via lipid-sensitive nuclear receptors (i.e., FXR and LXR).
CI  - (c) 2022 Tianjin Press of Chinese Herbal Medicines. Published by ELSEVIER B.V.
FAU - Bao, Shuyin
AU  - Bao S
AD  - Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu 
      University, Tongliao 028000, China.
AD  - Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for 
      Cardio-Cerebral Vascular System, Tongliao 028000, China.
AD  - Jilin Key Laboratory for Traditional Chinese Korean Medicine, College of 
      Pharmacy, Yanbian University, Yanji 133002, China.
FAU - Wang, Xiuzhi
AU  - Wang X
AD  - Department of Medicines and Foods, Tongliao Vocational College, Tongliao 028000, 
      China.
FAU - Ma, Qianqian
AU  - Ma Q
AD  - Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu 
      University, Tongliao 028000, China.
AD  - Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for 
      Cardio-Cerebral Vascular System, Tongliao 028000, China.
FAU - Wei, Chengxi
AU  - Wei C
AD  - Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu 
      University, Tongliao 028000, China.
AD  - Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for 
      Cardio-Cerebral Vascular System, Tongliao 028000, China.
FAU - Nan, Jixing
AU  - Nan J
AD  - Jilin Key Laboratory for Traditional Chinese Korean Medicine, College of 
      Pharmacy, Yanbian University, Yanji 133002, China.
FAU - Ao, Wuliji
AU  - Ao W
AD  - Research and development center, Inner Mongolia Research Institute of Traditional 
      Mongolian Medicine Engineering Technology, Tongliao 028000, China.
AD  - Mongolian Medicine R&D National Local Union Engineering Research Center, Inner 
      Mongolia Minzu University, Tongliao 028000, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220719
PL  - Singapore
TA  - Chin Herb Med
JT  - Chinese herbal medicines
JID - 101556727
PMC - PMC9476729
OTO - NOTNLM
OT  - Mongolian medicine
OT  - Xike Rixijing Disease
OT  - nonalcoholic fatty liver disease
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2022/09/20 06:00
MHDA- 2022/09/20 06:01
PMCR- 2022/07/19
CRDT- 2022/09/19 04:02
PHST- 2021/12/01 00:00 [received]
PHST- 2022/02/17 00:00 [revised]
PHST- 2022/06/15 00:00 [accepted]
PHST- 2022/09/19 04:02 [entrez]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2022/09/20 06:01 [medline]
PHST- 2022/07/19 00:00 [pmc-release]
AID - S1674-6384(22)00063-6 [pii]
AID - 10.1016/j.chmed.2022.06.003 [doi]
PST - epublish
SO  - Chin Herb Med. 2022 Jul 19;14(3):367-375. doi: 10.1016/j.chmed.2022.06.003. 
      eCollection 2022 Jul.