PMID- 36118114
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220920
IS  - 1662-5145 (Print)
IS  - 1662-5145 (Electronic)
IS  - 1662-5145 (Linking)
VI  - 16
DP  - 2022
TI  - Prospects and hot spots for mammalian target of rapamycin in the field of 
      neuroscience from 2002 to 2021.
PG  - 940265
LID - 10.3389/fnint.2022.940265 [doi]
LID - 940265
AB  - Mammalian target of rapamycin (mTOR) is an important molecule that regulates cell 
      metabolism, growth, and proliferation in the nervous system. This study aimed to 
      present the current study hot spots and predict the future development trend of 
      the mTOR pathway in neurologic diseases using bibliometrics. We referred to the 
      publications in the Web of Science Core Collection database. VOSviewer and 
      CiteSpace programs were used to evaluate countries/regions, institutions, 
      authors, journals, keywords, and citations showing the current study focus and 
      predicting the future trend of mTOR in neuroscience. The search date ended on 19 
      June 2022, and there were 3,029 articles on mTOR in neuroscience from 2002 to 
      2021. Visual analysis showed that although the number of publications declined 
      slightly in some years, the number of publications related to mTOR generally 
      showed an upward trend, reaching its peak in 2021. It had the largest number of 
      publications in the United States. Keywords and literature analysis showed that 
      protein synthesis regulation, ischemia, mitochondrial dysfunction, oxidative 
      stress, and neuroinflammation may be hot spots and future directions of the 
      nervous system in mTOR studies. Recently, the most studied neurological diseases 
      are Alzheimer's disease (AD), tuberous sclerosis complex (TSC), and depression, 
      which are still worthy of further studies by researchers in the future. This can 
      provide a useful reference for future researchers to study mTOR further in the 
      field of neuroscience.
CI  - Copyright (c) 2022 Li, Xia, Luo, Zhu, Luo, Yang and Shang.
FAU - Li, Lijun
AU  - Li L
AD  - Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research 
      Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of 
      Nanchang University, Nanchang, China.
FAU - Xia, Xiaojing
AU  - Xia X
AD  - Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research 
      Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of 
      Nanchang University, Nanchang, China.
FAU - Luo, Yunfeng
AU  - Luo Y
AD  - Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research 
      Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of 
      Nanchang University, Nanchang, China.
FAU - Zhu, Yuanting
AU  - Zhu Y
AD  - Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research 
      Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of 
      Nanchang University, Nanchang, China.
FAU - Luo, Xuhong
AU  - Luo X
AD  - Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research 
      Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of 
      Nanchang University, Nanchang, China.
FAU - Yang, Baolin
AU  - Yang B
AD  - Department of Human Anatomy, School of Basic Medicine, Nanchang University, 
      Nanchang, China.
FAU - Shang, Lei
AU  - Shang L
AD  - Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research 
      Institute of Ophthalmology and Visual Science, Affiliated Eye Hospital of 
      Nanchang University, Nanchang, China.
LA  - eng
PT  - Journal Article
DEP - 20220901
PL  - Switzerland
TA  - Front Integr Neurosci
JT  - Frontiers in integrative neuroscience
JID - 101477950
PMC - PMC9477085
OTO - NOTNLM
OT  - CiteSpace
OT  - VOSviewer
OT  - bibliometric analysis
OT  - citations
OT  - mTOR
OT  - neuroscience
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/20 06:00
MHDA- 2022/09/20 06:01
PMCR- 2022/01/01
CRDT- 2022/09/19 04:04
PHST- 2022/05/10 00:00 [received]
PHST- 2022/07/22 00:00 [accepted]
PHST- 2022/09/19 04:04 [entrez]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2022/09/20 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnint.2022.940265 [doi]
PST - epublish
SO  - Front Integr Neurosci. 2022 Sep 1;16:940265. doi: 10.3389/fnint.2022.940265. 
      eCollection 2022.