PMID- 36118586
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220920
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 10
DP  - 2022
TI  - Hybrid biomimetic assembly enzymes based on ZIF-8 as "intracellular scavenger" 
      mitigating neuronal damage caused by oxidative stress.
PG  - 991949
LID - 10.3389/fbioe.2022.991949 [doi]
LID - 991949
AB  - Superoxide dismutase (SOD) was immobilized in zeolite imidazolate framework-8 
      (ZIF-8) through biomimetic mineralization method, namely SOD@ZIF-8, which was 
      then used in the treatment of nerve damage by eliminating reactive oxygen species 
      (ROS). A series of chemical characterization and enzymatic activity researches 
      revealed that SOD was successfully embedded into ZIF-8 without apparent influence 
      on the antioxidant activity of SOD. Cell level experiments showed that SOD@ZIF-8 
      could be effectively endocytosed by cells. The activity of SOD@ZIF-8 in 
      scavenging ROS played a critical role in protecting SHSY-5Y cells from 
      MPP(+)-induced cell model and relieving cell apoptosis, indicating that SOD@ZIF-8 
      could effectively rescue ROS-mediated neurological disorders though removing 
      excessive ROS produced in vitro.
CI  - Copyright (c) 2022 Li, Feng, Chang, Liu, Tang and Bai.
FAU - Li, Qing
AU  - Li Q
AD  - Department of Molecular Pathology, Application Center for Precision Medicine, The 
      Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
FAU - Feng, Ruixia
AU  - Feng R
AD  - Department of Critical Care Medicine, Second Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Chang, Zhaohui
AU  - Chang Z
AD  - Department of Molecular Pathology, Application Center for Precision Medicine, The 
      Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
FAU - Liu, Xiaojun
AU  - Liu X
AD  - Department of Critical Care Medicine, Second Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
FAU - Tang, Hao
AU  - Tang H
AD  - National Health Commission Key Laboratory of Cardiovascular Regenerative 
      Medicine, Heart Center of Henan Provincial People's Hospital, Central China Fuwai 
      Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital and 
      Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou, 
      China.
FAU - Bai, Qian
AU  - Bai Q
AD  - Department of Critical Care Medicine, Second Affiliated Hospital of Zhengzhou 
      University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220831
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC9471668
OTO - NOTNLM
OT  - ROS scavenging
OT  - SOD@ZIF-8
OT  - biomimetic mineralization
OT  - nerve damage
OT  - neurological disorders
EDAT- 2022/09/20 06:00
MHDA- 2022/09/20 06:01
PMCR- 2022/01/01
CRDT- 2022/09/19 04:13
PHST- 2022/07/12 00:00 [received]
PHST- 2022/08/03 00:00 [accepted]
PHST- 2022/09/19 04:13 [entrez]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2022/09/20 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 991949 [pii]
AID - 10.3389/fbioe.2022.991949 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2022 Aug 31;10:991949. doi: 10.3389/fbioe.2022.991949. 
      eCollection 2022.