PMID- 36119939
OWN - NLM
STAT- MEDLINE
DCOM- 20220920
LR  - 20220920
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2022
DP  - 2022
TI  - Clinical Clues to Differentiate between Dermatophyte Onychomycosis (DP-OM) and 
      Dermatophytoma-Like Traumatic Onychodystrophy (DP-TO).
PG  - 8519376
LID - 10.1155/2022/8519376 [doi]
LID - 8519376
AB  - BACKGROUND: Dermatophytoma is a recalcitrant condition of onychomycosis (OM). It 
      presents as a white- or yellow-colored fungal mass that appears linear/triangular 
      or round on a nail plate. Traumatic onychodystrophy (TO) can present with 
      dermatophytoma-like lesions. Typically, OM and TO are not clinically 
      distinguishable. Mycological testing is the gold standard for differentiating 
      these disorders. OBJECTIVES: This study is aimed at differentiating between the 
      clinical and dermoscopic factors related to dermatophytoma onychomycosis (DP-OM) 
      and dermatophytoma-like traumatic onychodystrophy (DP-TO). METHODS: A 
      retrospective study was conducted of patients with dermatophytoma-like nail 
      lesions who visited the Siriraj Nail Clinic between January 2010 and July 2020. 
      The diagnosis of DP-OM was made by direct microscopy, fungal cultures, and 
      histopathology of nail clippings. RESULTS: A total of 36 nails were included in 
      the study. Thirteen nails were DP-OM, and 23 nails were DP-TO. The demographic 
      data and risk factors for the 2 groups were not significantly different. 
      Dermatophytoma lesions were found on the lateral side of nails in 12 cases of 
      DP-OM (92.3%) and 11 cases of DP-TO (47.8%; P = 0.008). DP-OM was associated with 
      longitudinal striae adjacent to dermatophytoma (69.2% vs. 30.4%; P = 0.024), 
      sulfur-nugget-like subungual debris (23.1% vs. 0%; P = 0.040), and scale on the 
      ipsilateral foot (69.2% vs. 8.7%; P < 0.001). DP-TO was associated with a 
      homogenous, whitish discoloration (47.8% vs. 7.7%; P = 0.014) and a sharp edge of 
      the onycholytic area (43.5% vs. 0%; P = 0.005). CONCLUSIONS: The lateral location 
      of dermatophytoma, adjacent striae, sulfur-nugget-like debris, and scale on the 
      ipsilateral foot were significantly associated with DP-OM. Dermoscopic 
      examination (dorsal and hyponychium views) and foot examination are beneficial 
      for distinguishing between DP-OM and DP-TO.
CI  - Copyright (c) 2022 Sumanas Bunyaratavej et al.
FAU - Bunyaratavej, Sumanas
AU  - Bunyaratavej S
AUID- ORCID: 0000-0002-0852-7742
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
FAU - Pattanaprichakul, Penvadee
AU  - Pattanaprichakul P
AUID- ORCID: 0000-0002-3293-7813
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
FAU - Sitthinamsuwan, Panitta
AU  - Sitthinamsuwan P
AUID- ORCID: 0000-0002-8218-5787
AD  - Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
FAU - Pongkittilar, Bawonpak
AU  - Pongkittilar B
AUID- ORCID: 0000-0002-2028-0535
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
FAU - Prasertsook, Suthasanee
AU  - Prasertsook S
AUID- ORCID: 0000-0002-1152-9597
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
FAU - Wongdama, Supisara
AU  - Wongdama S
AUID- ORCID: 0000-0002-3818-6889
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
FAU - Yan, Chadakan
AU  - Yan C
AUID- ORCID: 0000-0002-5347-5822
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
FAU - Leeyaphan, Charussri
AU  - Leeyaphan C
AUID- ORCID: 0000-0001-8430-376X
AD  - Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, 2 Wanglang Road, Bangkok Noi, Bangkok 10700, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20220909
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 70FD1KFU70 (Sulfur)
SB  - IM
MH  - *Arthrodermataceae
MH  - Humans
MH  - *Nail Diseases
MH  - *Nails, Malformed
MH  - *Onychomycosis/diagnosis/pathology
MH  - Retrospective Studies
MH  - Sulfur
PMC - PMC9481322
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/09/20 06:00
MHDA- 2022/09/21 06:00
PMCR- 2022/09/09
CRDT- 2022/09/19 04:34
PHST- 2022/06/20 00:00 [received]
PHST- 2022/09/01 00:00 [accepted]
PHST- 2022/09/19 04:34 [entrez]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2022/09/21 06:00 [medline]
PHST- 2022/09/09 00:00 [pmc-release]
AID - 10.1155/2022/8519376 [doi]
PST - epublish
SO  - Biomed Res Int. 2022 Sep 9;2022:8519376. doi: 10.1155/2022/8519376. eCollection 
      2022.