PMID- 36120812 OWN - NLM STAT- MEDLINE DCOM- 20221014 LR - 20230203 IS - 1473-5628 (Electronic) IS - 0143-3636 (Linking) VI - 43 IP - 11 DP - 2022 Nov 1 TI - Comparing the diagnostic accuracy of PET and CMR for the measurement of left ventricular volumes and ejection fraction: a system review and meta-analysis. PG - 1143-1154 LID - 10.1097/MNM.0000000000001612 [doi] AB - BACKGROUND: Cardiac magnetic resonance (CMR) has been recognized as the gold standard for the evaluation of left ventricular (LV) function. Cardiac gated PET allows the simultaneous assessment of LV function with the evaluation of myocardial perfusion and metabolism. But the correlations between PET and CMR remain controversial. METHODS: We conducted a systematic electronic search of PubMed, Embase and the Cochrane Library . Forest plot, spearman correlation analysis and Bland-Altman analysis were used to evaluate the correlations between PET and CMR. RESULTS: Pooled analysis of 13 studies showed that PET underestimated left ventricular end-diastolic volumes (LVEDV) [mean difference (MD), -15.30; 95% confidence interval (CI), -23.10 to -7.50; P < 0.001] and left ventricular end-systolic volumes (LVESV) (MD, -6.20; 95% CI, -12.58 to 0.17; P = 0.06) but not left ventricular ejection fraction (LVEF) (MD, -0.35; 95% CI, -1.75 to 1.06; P = 0.63). Overall, there were very good correlations between PET and CMR measurements for LVEDV ( r , 0.897), LVESV ( r , 0.924) and LVEF ( r , 0.898). Subgroup analysis indicated that LVEDV >/=180 ml and LVEF <40% reduced the accuracy of PET, especially the measurement of LVEF ( r , LVEDV >/=180 vs . r , LVEDV < 180 : 0.821 vs. 0.944; r , LVEF < 40% vs . r , LVEF >/=40% : 0.784 vs. 0.901). CONCLUSIONS: Correlations between PET and CMR measurements of LVEDV, LVESV and LVEF were excellent, but these two methods could not be used interchangeably for accurate measurements of LV volume and LVEF in patients with significantly increased LV volume and decreased LVEF. CI - Copyright (c) 2022 Wolters Kluwer Health, Inc. All rights reserved. FAU - Ye, Yong AU - Ye Y AD - Department of Radiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, Hubei Province. FAU - Yang, Ying AU - Yang Y AD - Department of Cardiology, School of Clinical Medicine, Tsinghua University, NO.1, Tsinghua Yuan, Haidian District, Beijing, China. FAU - Gong, Jie AU - Gong J AD - Department of Radiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, Hubei Province. FAU - Shao, Wen-Wen AU - Shao WW AD - Department of Radiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, Hubei Province. FAU - Yu, Cheng-Xin AU - Yu CX AD - Department of Radiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, Hubei Province. LA - eng PT - Journal Article PT - Meta-Analysis DEP - 20220919 PL - England TA - Nucl Med Commun JT - Nuclear medicine communications JID - 8201017 SB - IM MH - *Heart Ventricles/diagnostic imaging MH - Humans MH - Magnetic Resonance Spectroscopy MH - Positron-Emission Tomography/methods MH - Stroke Volume MH - *Ventricular Dysfunction, Left MH - Ventricular Function, Left EDAT- 2022/09/20 06:00 MHDA- 2022/10/15 06:00 CRDT- 2022/09/19 04:49 PHST- 2022/09/20 06:00 [pubmed] PHST- 2022/10/15 06:00 [medline] PHST- 2022/09/19 04:49 [entrez] AID - 00006231-202211000-00006 [pii] AID - 10.1097/MNM.0000000000001612 [doi] PST - ppublish SO - Nucl Med Commun. 2022 Nov 1;43(11):1143-1154. doi: 10.1097/MNM.0000000000001612. Epub 2022 Sep 19.