PMID- 36121111
OWN - NLM
STAT- MEDLINE
DCOM- 20230222
LR  - 20230222
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 50
IP  - 3
DP  - 2023 Mar
TI  - Increased expression of human herpes virus 6 receptor CD134/OX40 in skin lesions 
      of patients with drug-induced hypersensitivity syndrome/drug reaction with 
      eosinophilia and systemic symptoms.
PG  - 387-392
LID - 10.1111/1346-8138.16575 [doi]
AB  - CD134/OX40, a member of the tumor necrosis factor receptor superfamily, is a 
      cell-specific receptor for human herpesvirus 6 (HHV-6) variant B. Patients with 
      drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and 
      systemic symptoms (DRESS) present a significant increase in CD134 expression in 
      peripheral blood CD4(+) T cells. We aimed to investigate the frequency of 
      CD134(+) CD4 T cells infiltrating skin lesions in patients with DIHS/DRESS and 
      its association with disease severity. We retrospectively included 21 patients 
      with DIHS/DRESS and 11 patients with erythema multiforme (EM). By 
      immunohistochemistry, the frequency of CD134(+) CD4 T cells in DIHS was 
      significantly higher than that in EM (p = 0.0083). The DIHS/DRESS severity score 
      was significantly correlated with the frequency of CD134(+) CD4 T cells 
      (p = 0.0272); moreover, there was a significant difference between severe and 
      mild/moderate cases. Double immunofluorescence staining revealed that numerous 
      cells presented CD134/CD4 and CD134/Foxp3 overlap in patients with DIHS/DRESS. 
      These data suggest increased susceptibility to HHV-6 infection at localized skin 
      sites. HHV-6 may be involved in the mechanism underlying the progression and 
      pathophysiology of DIHS/DRESS.
CI  - (c) 2022 Japanese Dermatological Association.
FAU - Lee, Eun Seon
AU  - Lee ES
AUID- ORCID: 0000-0002-9917-0960
AD  - Departments of Dermatology, Showa University School of Medicine, Shinagawa-ku, 
      Tokyo, Japan.
AD  - Departments of Pharmacology, Showa University School of Medicine, Shinagawa-ku, 
      Tokyo, Japan.
FAU - Kiuchi, Yuji
AU  - Kiuchi Y
AD  - Departments of Pharmacology, Showa University School of Medicine, Shinagawa-ku, 
      Tokyo, Japan.
FAU - Inomata, Naoko
AU  - Inomata N
AUID- ORCID: 0000-0002-1989-9824
AD  - Departments of Dermatology, Showa University School of Medicine, Shinagawa-ku, 
      Tokyo, Japan.
FAU - Sueki, Hirohiko
AU  - Sueki H
AUID- ORCID: 0000-0001-5691-7211
AD  - Departments of Dermatology, Showa University School of Medicine, Shinagawa-ku, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20220919
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
SB  - IM
MH  - Humans
MH  - *Drug Hypersensitivity Syndrome
MH  - *Herpesvirus 6, Human
MH  - Retrospective Studies
MH  - *Eosinophilia/pathology
MH  - Skin/pathology
OTO - NOTNLM
OT  - CD134/OX40
OT  - drug reaction with eosinophilia and systemic symptoms
OT  - drug-induced hypersensitivity syndrome
OT  - erythema multiforme
OT  - human herpes virus-6 receptor
EDAT- 2022/09/20 06:00
MHDA- 2023/02/22 06:00
CRDT- 2022/09/19 07:32
PHST- 2022/08/18 00:00 [revised]
PHST- 2022/02/24 00:00 [received]
PHST- 2022/08/23 00:00 [accepted]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2023/02/22 06:00 [medline]
PHST- 2022/09/19 07:32 [entrez]
AID - 10.1111/1346-8138.16575 [doi]
PST - ppublish
SO  - J Dermatol. 2023 Mar;50(3):387-392. doi: 10.1111/1346-8138.16575. Epub 2022 Sep 
      19.