PMID- 36123314
OWN - NLM
STAT- MEDLINE
DCOM- 20221103
LR  - 20230110
IS  - 1469-445X (Electronic)
IS  - 0958-0670 (Print)
IS  - 0958-0670 (Linking)
VI  - 107
IP  - 11
DP  - 2022 Nov
TI  - Early chronotype with metabolic syndrome favours resting and exercise fat 
      oxidation in relation to insulin-stimulated non-oxidative glucose disposal.
PG  - 1255-1264
LID - 10.1113/EP090613 [doi]
AB  - NEW FINDINGS: What is the central question of this study? Chronotype reflects 
      differences in circadian-mediated metabolic and hormonal profiles. But, does 
      resting and/or exercise fuel use differ in early versus late chronotype as it 
      relates to insulin sensitivity? What are the main finding and its importance? 
      Early chronotypes with metabolic syndrome utilized more fat during rest and 
      exercise independent of aerobic fitness when compared with late chronotypes. 
      Early chronotypes were also more physically active throughout the day. Greater 
      fat use was related to non-oxidative glucose disposal. These findings suggest 
      that early chronotypes have differences in fuel selection that associate with 
      type 2 diabetes risk. ABSTRACT: Early chronotypes (ECs) are often 
      insulin-sensitive, in part, due to physical activity behaviour. It is unclear, 
      however, if chronotypes differ in resting and/or exercise fuel oxidation in 
      relation to insulin action. Using the Morningness-Eveningness Questionnaire 
      (MEQ), adults with metabolic syndrome (ATP III criteria) were classified as EC 
      (MEQ = 63.7 +/- 0.9, n = 24 (19F), 54.2 +/- 1.2 years) or late chronotype (LC; 
      MEQ = 47.2 +/- 1.4, n = 27 (23F), 55.3 +/- 1.5 years). Carbohydrate (CHO) and fat 
      oxidation (FOX, indirect calorimetry) were determined at rest, 55% and 85% 
      V̇O2max , along with heart rate and rating of perceived exertion. Physical 
      activity patterns (accelerometers), body composition (DXA) and insulin 
      sensitivity (clamp, 40 mU/m(2) /min, 90 mg/dl) with an indirect calorimetry for 
      non-oxidative glucose disposal (NOGD) were also determined. While demographics 
      were similar, ECs had higher V̇O2max (P = 0.02), NOGD (P < 0.001) and resting FOX 
      (P = 0.02) than LCs. Both groups increased CHO reliance during exercise at 55% 
      and 85% V̇O2max (test effect, P < 0.01) from rest, although ECs used more fat 
      (group effect, P < 0.01). ECs had lower sedentary behaviour and more physical 
      activity during morning/midday (both, P < 0.05). FOX at 55% V̇O2max correlated 
      with V̇O2max (r = 0.425, P = 0.004) whereas FOX at 85% V̇O2max related to NOGD 
      (r = 0.392, P = 0.022). ECs with metabolic syndrome used more fat in relation to 
      insulin-stimulated NOGD.
CI  - (c) 2022 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on 
      behalf of The Physiological Society.
FAU - Malin, Steven K
AU  - Malin SK
AUID- ORCID: 0000-0002-7360-6711
AD  - Rutgers University, New Brunswick, NJ, USA.
AD  - University of Virginia, Charlottesville, VA, USA.
AD  - Division of Endocrinology, Metabolism and Nutrition, Rutgers University, New 
      Brunswick, NJ, USA.
AD  - New Jersey Institute for Food, Nutrition and Health, Rutgers University, New 
      Brunswick, NJ, USA.
AD  - Institute of Translational Medicine and Science, Rutgers University, New 
      Brunswick, NJ, USA.
FAU - Remchak, Mary-Margaret E
AU  - Remchak ME
AD  - Rutgers University, New Brunswick, NJ, USA.
FAU - Smith, Anthony J
AU  - Smith AJ
AD  - Rutgers University, New Brunswick, NJ, USA.
FAU - Ragland, Tristan J
AU  - Ragland TJ
AUID- ORCID: 0000-0002-8741-2782
AD  - Rutgers University, New Brunswick, NJ, USA.
FAU - Heiston, Emily M
AU  - Heiston EM
AD  - University of Virginia, Charlottesville, VA, USA.
AD  - Virginia Commonwealth University, Richmond, VA, USA.
FAU - Cheema, Udeyvir
AU  - Cheema U
AD  - University of Virginia, Charlottesville, VA, USA.
LA  - eng
GR  - R01 HL130296/HL/NHLBI NIH HHS/United States
GR  - T32 HL149645/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220919
PL  - England
TA  - Exp Physiol
JT  - Experimental physiology
JID - 9002940
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Insulin
MH  - Glucose/metabolism
MH  - *Insulin Resistance
MH  - *Metabolic Syndrome
MH  - Blood Glucose/metabolism
MH  - *Diabetes Mellitus, Type 2
MH  - Exercise/physiology
PMC - PMC9633545
MID - NIHMS1830632
OTO - NOTNLM
OT  - exercise intensity
OT  - insulin sensitivity
OT  - metabolic syndrome
OT  - oxidative capacity
OT  - substrate utilization
COIS- The authors report no conflict of interest.
EDAT- 2022/09/20 06:00
MHDA- 2022/11/04 06:00
PMCR- 2023/01/08
CRDT- 2022/09/19 22:32
PHST- 2022/06/07 00:00 [received]
PHST- 2022/08/08 00:00 [accepted]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2022/11/04 06:00 [medline]
PHST- 2022/09/19 22:32 [entrez]
PHST- 2023/01/08 00:00 [pmc-release]
AID - EPH13235 [pii]
AID - 10.1113/EP090613 [doi]
PST - ppublish
SO  - Exp Physiol. 2022 Nov;107(11):1255-1264. doi: 10.1113/EP090613. Epub 2022 Sep 19.