PMID- 36123604 OWN - NLM STAT- MEDLINE DCOM- 20220922 LR - 20220924 IS - 1471-2415 (Electronic) IS - 1471-2415 (Linking) VI - 22 IP - 1 DP - 2022 Sep 19 TI - Clinical characteristics of glaucoma patients with various risk factors. PG - 373 LID - 10.1186/s12886-022-02587-5 [doi] LID - 373 AB - BACKGROUND: Glaucoma is multifactorial, but the interrelationship between risk factors and structural changes remains unclear. Here, we adjusted for confounding factors in glaucoma patients with differing risk factors, and compared differences in structure and susceptible areas in the optic disc and macula. METHODS: In 458 eyes with glaucoma, we determined confounding factors for intraocular pressure (IOP), central corneal thickness (CCT), axial length (AL), LSFG-measured ocular blood flow (OBF), which was assessed with laser speckle flowgraphy-measured mean blur rate in the tissue area (MT) of the optic nerve head, biological antioxidant potential (BAP), and systemic abnormalities in diastolic blood pressure (dBP). To compensate for measurement bias, we also analyzed corrected IOP (cIOP; corrected for CCT) and corrected MT (cMT; corrected for age, weighted retinal ganglion cell count, and AL). Then, we determined the distribution of these parameters in low-, middle-, and high-value subgroups and compared them with the Kruskal-Wallis test. Pairwise comparisons used the Steel-Dwass test. RESULTS: The high-cIOP subgroup had significantly worse mean deviation (MD), temporal, superior, and inferior loss of circumpapillary retinal nerve fiber layer thickness (cpRNFLT), and large cupping. The low-CCT subgroup had temporal cpRNFLT loss; the high-CCT subgroup had low cup volume. The high-AL subgroup had macular ganglion cell complex thickness (GCCT) loss; the low-AL subgroup had temporal cpRNFLT loss. The high-systemic-dBP subgroup had worse MD, total, superior, and inferior cpRNFLT loss and macular GCCT loss. The low-BAP subgroup had more male patients, higher dBP, and cpRNFLT loss in the 10 o'clock area. The high-OBF subgroup had higher total, superior and temporal cpRNFLT and macular GCCT. CONCLUSIONS: Structural changes and local susceptibility to glaucomatous damage show unique variations in patients with different risk factors, which might suggest that specific risk factors induce specific types of pathogenesis and corresponding glaucoma phenotypes. Our study may open new avenues for the development of precision medicine for glaucoma. CI - (c) 2022. The Author(s). FAU - Omodaka, Kazuko AU - Omodaka K AD - Department of Ophthalmology, Tohoku University, Graduate School of Medicine, Sendai, Japan. AD - Department of Ophthalmic Imaging and Information Analytics, Tohoku University, Graduate School of Medicine, Sendai, Japan. FAU - Kikawa, Tsutomu AU - Kikawa T AD - R and D Division, Topcon Corporation, Tokyo, Japan. FAU - Kabakura, Sayaka AU - Kabakura S AD - Department of Ophthalmology, Tohoku University, Graduate School of Medicine, Sendai, Japan. FAU - Himori, Noriko AU - Himori N AD - Department of Ophthalmology, Tohoku University, Graduate School of Medicine, Sendai, Japan. AD - Department of Aging Vision Healthcare, Tohoku University Graduate School of Biomedical Engineering, Sendai, Japan. FAU - Tsuda, Satoru AU - Tsuda S AD - Department of Ophthalmology, Tohoku University, Graduate School of Medicine, Sendai, Japan. FAU - Ninomiya, Takahiro AU - Ninomiya T AD - Department of Ophthalmology, Tohoku University, Graduate School of Medicine, Sendai, Japan. FAU - Takahashi, Naoki AU - Takahashi N AD - Department of Ophthalmology, Tohoku University, Graduate School of Medicine, Sendai, Japan. FAU - Pak, Kyongsun AU - Pak K AD - Division of Biostatistics, Center for Clinical Research, National Center for Child Health and Development, Tokyo, Japan. FAU - Takeda, Noriyasu AU - Takeda N AD - R and D Division, Topcon Corporation, Tokyo, Japan. FAU - Akiba, Masahiro AU - Akiba M AD - R and D Division, Topcon Corporation, Tokyo, Japan. AD - Cloud-Based Eye Disease Diagnosis Joint Research Team, Riken, Wako, Japan. FAU - Nakazawa, Toru AU - Nakazawa T AD - Department of Ophthalmology, Tohoku University, Graduate School of Medicine, Sendai, Japan. ntoru@oph.med.tohoku.ac.jp. AD - Department of Ophthalmic Imaging and Information Analytics, Tohoku University, Graduate School of Medicine, Sendai, Japan. ntoru@oph.med.tohoku.ac.jp. LA - eng GR - K.O. 21K09690/the JST Center for Revitalization Promotion and KAKENHI Grants-in-Aid for Scientific Research (C)/ GR - T.N. 20H03838/JSPS KAKENHI Grants-in-Aid for Scientific Research (B)/ GR - T.N. 21K19548/JSPS KAKENHI Grants-in-Aid for Exploratory Research/ GR - JP21ak0101110/AMED/ PT - Journal Article DEP - 20220919 PL - England TA - BMC Ophthalmol JT - BMC ophthalmology JID - 100967802 RN - 0 (Antioxidants) SB - IM MH - Antioxidants MH - *Glaucoma MH - Humans MH - Male MH - *Optic Disk/pathology MH - Risk Factors MH - Tomography, Optical Coherence PMC - PMC9484257 OTO - NOTNLM OT - Blood pressure OT - Glaucoma OT - Individual treatment for glaucoma OT - Optical coherence tomography OT - Risk factors COIS- Co-authors TK, NT, and MA are employed by Topcon Corporation, a commercial company. There are no patents, products in development or marketed products to declare. The other authors have no potential conflicts of interest associated with this manuscript. EDAT- 2022/09/20 06:00 MHDA- 2022/09/23 06:00 PMCR- 2022/09/19 CRDT- 2022/09/19 23:32 PHST- 2022/05/06 00:00 [received] PHST- 2022/08/29 00:00 [accepted] PHST- 2022/09/19 23:32 [entrez] PHST- 2022/09/20 06:00 [pubmed] PHST- 2022/09/23 06:00 [medline] PHST- 2022/09/19 00:00 [pmc-release] AID - 10.1186/s12886-022-02587-5 [pii] AID - 2587 [pii] AID - 10.1186/s12886-022-02587-5 [doi] PST - epublish SO - BMC Ophthalmol. 2022 Sep 19;22(1):373. doi: 10.1186/s12886-022-02587-5.