PMID- 36123748
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220924
IS  - 1674-9782 (Print)
IS  - 2049-1891 (Electronic)
IS  - 1674-9782 (Linking)
VI  - 13
IP  - 1
DP  - 2022 Sep 20
TI  - Associations between maternal vitamin D status and porcine litter characteristics 
      throughout gestation.
PG  - 106
LID - 10.1186/s40104-022-00760-w [doi]
LID - 106
AB  - Emerging evidence suggests an important role of vitamin D in the establishment 
      and maintenance of pregnancy, and the regulation of foetal growth across 
      mammalian species. However, the temporal changes in maternal vitamin D status 
      throughout gestation in the pig and the relationship between maternal vitamin D 
      status and litter characteristics of interest across gestation remain poorly 
      understood and under-investigated. The abundance of 25(OH)D in maternal plasma 
      was quantified by HPLC-MS/MS at gestational days (GD) 18, 30, 45, 60 and 90 
      (n = 5-11 gilts/GD). Maternal plasma 25(OH)D concentrations significantly 
      increased between GD18 and GD30 (P < 0.05). The relationship between maternal 
      vitamin D metabolite concentrations and litter characteristics of interest 
      including gilt weight, ovulation rate, mean litter weight, number of live 
      foetuses, percentage prenatal survival, and sex ratio of the litter was assessed. 
      Maternal 25(OH)D (P = 0.059) concentrations tended to be positively associated 
      with percentage prenatal survival on GD60. On GD90, maternal 25(OH)D (P < 0.05) 
      concentrations were inversely associated with gilt weight. Maternal plasma 
      25(OH)D concentrations were inversely associated with the percentage of male 
      foetuses in the litter on GD90 (P < 0.05). This study has provided novel insights 
      into temporal changes in maternal vitamin D status throughout gestation and the 
      relationship between maternal vitamin D status and the economically important 
      litter characteristics of gilt weight, percentage prenatal survival and 
      percentage of male foetuses in the litter. Improving the understanding of the 
      role of vitamin D across important developmental timepoints in relation to foetal 
      growth is essential to improve reproductive success in livestock species.
CI  - (c) 2022. The Author(s).
FAU - Stenhouse, Claire
AU  - Stenhouse C
AD  - Functional Genetics and Development Division, The Roslin Institute and Royal 
      (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, EH25 
      9RG, UK. Claire.Stenhouse@ag.tamu.edu.
AD  - Current Affiliation, Department of Animal Science, Texas A&M University, College 
      Station, Texas, 77843-2471, USA. Claire.Stenhouse@ag.tamu.edu.
FAU - Hurst, Emma
AU  - Hurst E
AD  - Clinical Sciences Division, The Roslin Institute and Royal (Dick) School of 
      Veterinary Studies, University of Edinburgh, Midlothian, EH25 9RG, UK.
FAU - Mellanby, Richard J
AU  - Mellanby RJ
AD  - Clinical Sciences Division, The Roslin Institute and Royal (Dick) School of 
      Veterinary Studies, University of Edinburgh, Midlothian, EH25 9RG, UK.
FAU - Ashworth, Cheryl J
AU  - Ashworth CJ
AD  - Functional Genetics and Development Division, The Roslin Institute and Royal 
      (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, EH25 
      9RG, UK.
LA  - eng
GR  - BB/J004316/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - Studentship/College of Medicine and Veterinary Medicine, University of Edinburgh/
PT  - Journal Article
DEP - 20220920
PL  - England
TA  - J Anim Sci Biotechnol
JT  - Journal of animal science and biotechnology
JID - 101581293
PMC - PMC9487113
OTO - NOTNLM
OT  - Porcine
OT  - Pregnancy
OT  - Vitamin D
COIS- The authors declare that they have no competing interests.
EDAT- 2022/09/20 06:00
MHDA- 2022/09/20 06:01
PMCR- 2022/09/20
CRDT- 2022/09/19 23:43
PHST- 2022/04/05 00:00 [received]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/09/19 23:43 [entrez]
PHST- 2022/09/20 06:00 [pubmed]
PHST- 2022/09/20 06:01 [medline]
PHST- 2022/09/20 00:00 [pmc-release]
AID - 10.1186/s40104-022-00760-w [pii]
AID - 760 [pii]
AID - 10.1186/s40104-022-00760-w [doi]
PST - epublish
SO  - J Anim Sci Biotechnol. 2022 Sep 20;13(1):106. doi: 10.1186/s40104-022-00760-w.