PMID- 36125321
OWN - NLM
STAT- MEDLINE
DCOM- 20221220
LR  - 20230215
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 108
IP  - 1
DP  - 2022 Dec 17
TI  - Idiopathic Hirsutism and Metabolic Status: A Population-based Prospective Cohort 
      Study.
PG  - 114-123
LID - 10.1210/clinem/dgac538 [doi]
AB  - BACKGROUND: A limited number of studies have investigated the impact of 
      idiopathic hirsutism (IH) on cardiometabolic parameters with contradictory and 
      inconclusive results. This study aimed to explore the effect of IH on metabolic 
      outcomes. METHOD: In this population-based prospective study, 334 women with IH 
      and 1226 women as healthy controls were selected from Tehran Lipid and Glucose 
      Study. The generalized estimation equations method was applied to investigate the 
      secular longitudinal trends of metabolic indices, including fasting blood sugar 
      (FBS), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein 
      cholesterol (LDL), non-HDL, triglyceride (TG), systolic blood pressure (SBP), 
      diastolic blood pressure (DBP), and waist circumference (WC) in both groups. 
      Unadjusted and adjusted Cox regression models were applied to assess the hazard 
      ratios (HR) and 95% CIs for the association between IH and metabolic disorders. 
      Potential confounding factors such as age, body mass index, smoking, physical 
      activity, history of hypertension (HTN), and family history of diabetes were 
      included in the adjusted model. RESULTS: This study showed that compared with 
      healthy controls, women with IH had lower SHBG and higher total testosterone 
      (median [interquartile ratio; IQR]: 0.37 [0.16-0.70] vs 0.33 [0.14-0.58]; P = 
      0.01), free androgen index (median [IQR]: 0.85 [0.38-1.54] vs 0.54 [0.26-0.97]; P 
      = 0.001), androstenedione (median [IQR]: 1.60 [1.00-2.25] vs 1.10 [0.90-1.70]; P 
      = 0.001), and dehydroepiandrosterone sulfate (median [IQR]: 168.5 [91.1-227.8] vs 
      125.2 [66.3-181]; P = 0.001). Over time, mean changes of FBS, HDL-C, LDL-C, 
      non-HDL-C, TG, SBP, DBP, and WC were not significantly different in women with 
      IH, compared with healthy controls. According to the unadjusted Cox regression 
      model, except for type 2 diabetes mellitus (T2DM) (HR [95% CI]: 1.45 [1.00-2.11]) 
      P = 0.05; there was no statistically significant difference in hazard of 
      metabolic disorders (ie, HTN, pre-HTN, pre-T2DM, and metabolic syndrome) in IH, 
      compared with healthy controls. Besides, the adjusted Cox regression model showed 
      no significant differences in the hazard of these outcomes. CONCLUSION: This 
      study showed no significant difference in overtime mean changes of metabolic risk 
      factors and cardiometabolic outcomes in women with IH, compared with the healthy 
      control group, except marginally significant difference on T2DM, which 
      disappeared after further adjustment for potential confounders. Accordingly, 
      routine screening of women for these metabolic outcomes should not recommend.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Mahmoudieh, Leila
AU  - Mahmoudieh L
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Amiri, Mina
AU  - Amiri M
AUID- ORCID: 0000-0002-1126-9297
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Rahmati, Maryam
AU  - Rahmati M
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Habibi Moeini, Ali Siamak
AU  - Habibi Moeini AS
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Sarvghadi, Farzaneh
AU  - Sarvghadi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Azizi, Fereidoun
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Ramezani Tehrani, Fahimeh
AU  - Ramezani Tehrani F
AUID- ORCID: 0000-0002-1748-5687
AD  - Reproductive Endocrinology Research Center, Research Institute for Endocrine 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - 0 (Cholesterol, HDL)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
CIN - J Clin Endocrinol Metab. 2022 Nov 11;:. PMID: 36357007
MH  - Female
MH  - Humans
MH  - Prospective Studies
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Blood Glucose/metabolism
MH  - Hirsutism/epidemiology
MH  - Iran
MH  - *Metabolic Syndrome
MH  - Triglycerides
MH  - Cholesterol, HDL
MH  - Risk Factors
MH  - Cholesterol
MH  - *Hypertension
OTO - NOTNLM
OT  - Tehran lipid and glucose study (TLGS)
OT  - diabetes mellitus (T2DM)
OT  - hypertension (HTN)
OT  - idiopathic hirsutism (IH)
OT  - metabolic
OT  - metabolic syndrome (MetS)
COIS- Conflicts of Interest The authors have no conflict of interest to declare.
EDAT- 2022/09/21 06:00
MHDA- 2022/12/21 06:00
CRDT- 2022/09/20 09:22
PHST- 2022/05/30 00:00 [received]
PHST- 2022/09/21 06:00 [pubmed]
PHST- 2022/12/21 06:00 [medline]
PHST- 2022/09/20 09:22 [entrez]
AID - 6706602 [pii]
AID - 10.1210/clinem/dgac538 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2022 Dec 17;108(1):114-123. doi: 10.1210/clinem/dgac538.