PMID- 36126421
OWN - NLM
STAT- MEDLINE
DCOM- 20221013
LR  - 20221020
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 169
DP  - 2022 Nov
TI  - Prenatal exposure to mixtures of phthalates and phenols and body mass index and 
      blood pressure in Spanish preadolescents.
PG  - 107527
LID - S0160-4120(22)00454-8 [pii]
LID - 10.1016/j.envint.2022.107527 [doi]
AB  - BACKGROUND: Pregnant women are simultaneously exposed to several non-persistent 
      endocrine-disrupting chemicals, which may influence the risk of childhood obesity 
      and cardiovascular diseases later in life. Previous prospective studies have 
      mostly examined single-chemical effects, with inconsistent findings. We assessed 
      the association between prenatal exposure to phthalates and phenols, individually 
      and as a mixture, and body mass index (BMI) and blood pressure (BP) in 
      preadolescents. METHODS: We used data from the Spanish INMA birth cohort study 
      (n = 1,015), where the 1st and 3rd- trimester maternal urinary concentrations of 
      eight phthalate metabolites and six phenols were quantified. At 11 years of age, 
      we calculated BMI z-scores and measured systolic and diastolic BP. We estimated 
      individual chemical effects with linear mixed models and joint effects of the 
      chemical mixture with hierarchical Bayesian kernel machine regression (BKMR). 
      Analyses were stratified by sex and by puberty status. RESULTS: In 
      single-exposure models, benzophenone-3 (BP3) was nonmonotonically associated with 
      higher BMI z-score (e.g. Quartile (Q) 3: beta = 0.23 [95% CI = 0.03, 0.44] vs Q1) 
      and higher diastolic BP (Q2: beta = 1.27 [0.00, 2.53] mmHg vs Q1). Methyl paraben 
      (MEPA) was associated with lower systolic BP (Q4: beta = -1.67 [-3.31, -0.04] mmHg 
      vs Q1). No consistent associations were observed for the other compounds. Results 
      from the BKMR confirmed the single-exposure results and showed similar patterns 
      of associations, with BP3 having the highest importance in the mixture models, 
      especially among preadolescents who reached puberty status. No overall mixture 
      effect was found, except for a tendency of higher BMI z-score and lower systolic 
      BP in girls. CONCLUSIONS: Prenatal exposure to UV-filter BP3 may be associated 
      with higher BMI and diastolic BP during preadolescence, but there is little 
      evidence for an overall phthalate and phenol mixture effect.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Guil-Oumrait, Nuria
AU  - Guil-Oumrait N
AD  - ISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AD  - LABERCA, UMR1329, Oniris, INRAE, Nantes, France.
FAU - Montazeri, Parisa
AU  - Montazeri P
AD  - ISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Stratakis, Nikos
AU  - Stratakis N
AD  - ISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Warembourg, Charline
AU  - Warembourg C
AD  - Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sante, environnement 
      et travail) - UMR_S 1085, F-35000 Rennes, France.
FAU - Lopez-Espinosa, Maria-Jose
AU  - Lopez-Espinosa MJ
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; 
      FISABIO-Universitat Jaume I-Universitat de Valencia, Valencia, Spain; Faculty of 
      Nursing and Chiropody, University of Valencia, Valencia, Spain.
FAU - Vioque, Jesus
AU  - Vioque J
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Universidad 
      Miguel Hernandez, Alicante, Spain.
FAU - Santa-Marina, Loreto
AU  - Santa-Marina L
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Biodonostia, 
      Health Research Institute, Donostia, Gipuzkoa, Spain; Department of Health of the 
      Basque Government, Subdirectorate of Public Health of Gipuzkoa, Spain.
FAU - Jimeno-Romero, Alba
AU  - Jimeno-Romero A
AD  - CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain; Biodonostia, 
      Health Research Institute, Donostia, Gipuzkoa, Spain; Preventive Medicine and 
      Public Health Department, University of the Basque Country, Leioa, Bizkaia, 
      Spain.
FAU - Ventura, Rosa
AU  - Ventura R
AD  - Catalonian Antidoping Laboratory, Doping Control Research Group, IMIM, Barcelona, 
      Spain.
FAU - Monfort, Nuria
AU  - Monfort N
AD  - Catalonian Antidoping Laboratory, Doping Control Research Group, IMIM, Barcelona, 
      Spain.
FAU - Vrijheid, Martine
AU  - Vrijheid M
AD  - ISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain.
FAU - Casas, Maribel
AU  - Casas M
AD  - ISGlobal, Barcelona, Spain; Pompeu Fabra University (UPF), Barcelona, Spain; 
      CIBER de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. Electronic 
      address: maribel.casas@isglobal.org.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220915
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 0 (Parabens)
RN  - 0 (Phenols)
RN  - 0 (Phthalic Acids)
RN  - 339NCG44TV (Phenol)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Bayes Theorem
MH  - Blood Pressure
MH  - Body Mass Index
MH  - Child
MH  - Cohort Studies
MH  - *Environmental Pollutants/adverse effects/analysis
MH  - Female
MH  - Humans
MH  - Parabens/adverse effects/analysis
MH  - *Pediatric Obesity
MH  - Phenol
MH  - Phenols/analysis/toxicity
MH  - *Phthalic Acids/toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
OTO - NOTNLM
OT  - Benzophenone-3
OT  - Blood pressure (BP)
OT  - Body mass index (BMI)
OT  - Parabens
OT  - Phenols
OT  - Phthalates
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/09/21 06:00
MHDA- 2022/10/14 06:00
CRDT- 2022/09/20 18:18
PHST- 2022/02/02 00:00 [received]
PHST- 2022/07/29 00:00 [revised]
PHST- 2022/09/14 00:00 [accepted]
PHST- 2022/09/21 06:00 [pubmed]
PHST- 2022/10/14 06:00 [medline]
PHST- 2022/09/20 18:18 [entrez]
AID - S0160-4120(22)00454-8 [pii]
AID - 10.1016/j.envint.2022.107527 [doi]
PST - ppublish
SO  - Environ Int. 2022 Nov;169:107527. doi: 10.1016/j.envint.2022.107527. Epub 2022 
      Sep 15.