PMID- 36128166
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220922
IS  - 2229-5097 (Print)
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 13
DP  - 2022
TI  - Effect of drug use in the treatment of acute ischemic stroke: A scoping review.
PG  - 367
LID - 10.25259/SNI_561_2022 [doi]
LID - 367
AB  - BACKGROUND: Drugs of abuse have been associated with ischemic stroke; however, 
      the clinical presentation, outcomes, and treatment data in this population are 
      limited. The overall safety and efficacy of thrombolytic therapy and thrombectomy 
      in these patients remain unclear. This scoping review summarizes published 
      complications and clinical outcomes in patients with recent abuse of cocaine, 
      methamphetamine (MA), cannabis, decongestant, opioids, alcohol, and 
      3,4-methylenedioxymethamphetamine (MDMA) presenting with acute ischemic stroke. 
      METHODS: We conducted a scoping review of the primary literature that assessed 
      outcomes data of thrombolytic therapy or thrombectomy in drug users with acute 
      ischemic stroke. We searched PubMed, Ovid Medline, and Web of Science. 
      Demographic and stroke characteristics, treatment, complications, and clinical 
      outcomes at last follow-up were collected and summarized. RESULTS: We identified 
      51 studies in this review. Drugs of abuse of interest were cocaine (14 studies), 
      MDMA (one study), MA (eight studies), cannabis (23 studies), alcohol (two 
      studies), decongestants (one study), and opioids (two studies). Clinical 
      presentation and stroke presentation were most commonly described features. 
      Thrombectomy outcomes were reported for four patients total (two studies), all 
      with history of cocaine use. Thrombolysis treatment and outcomes were reported 
      for 8851 patients (five studies) with history of cocaine, alcohol, or cannabis. 
      Both treatments were pursued in three patients (three studies). Treatment 
      complications included intracerebral hemorrhage, vasospasm, and cerebral edema. 
      CONCLUSION: Evidence for thrombolytic and thrombectomy treatment in drug users 
      remains limited. Controlled studies are needed to examine complication profile 
      and outcomes following thrombolytic and thrombectomy treatment in this 
      population.
CI  - Copyright: (c) 2022 Surgical Neurology International.
FAU - Dabhi, Nisha
AU  - Dabhi N
AD  - Department of Neurosurgery, University of Virginia, Charlottesville, United 
      States.
FAU - Mastorakos, Panagiotis
AU  - Mastorakos P
AD  - Department of Neurosurgery, University of Virginia, Charlottesville, United 
      States.
FAU - Sokolowski, Jennifer D
AU  - Sokolowski JD
AD  - Department of Neurosurgery, University of Virginia, Charlottesville, United 
      States.
FAU - Kellogg, Ryan T
AU  - Kellogg RT
AD  - Department of Neurosurgery, University of Virginia, Charlottesville, United 
      States.
FAU - Park, Min S
AU  - Park MS
AD  - Department of Neurosurgery, University of Virginia, Charlottesville, United 
      States.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220819
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
PMC - PMC9479649
OTO - NOTNLM
OT  - Cerebrovascular accident
OT  - Drugs of abuse
OT  - Ischemic stroke
OT  - Thrombectomy
OT  - Thrombolysis
COIS- There are no conflicts of interest.
EDAT- 2022/09/22 06:00
MHDA- 2022/09/22 06:01
PMCR- 2022/08/19
CRDT- 2022/09/21 01:57
PHST- 2022/06/19 00:00 [received]
PHST- 2022/07/27 00:00 [accepted]
PHST- 2022/09/21 01:57 [entrez]
PHST- 2022/09/22 06:00 [pubmed]
PHST- 2022/09/22 06:01 [medline]
PHST- 2022/08/19 00:00 [pmc-release]
AID - 10.25259/SNI_561_2022 [pii]
AID - 10.25259/SNI_561_2022 [doi]
PST - epublish
SO  - Surg Neurol Int. 2022 Aug 19;13:367. doi: 10.25259/SNI_561_2022. eCollection 
      2022.