PMID- 36129571 OWN - NLM STAT- MEDLINE DCOM- 20221013 LR - 20230127 IS - 1535-1645 (Electronic) IS - 1523-3812 (Print) IS - 1523-3812 (Linking) VI - 24 IP - 10 DP - 2022 Oct TI - The Emerging Field of Psychedelic Psychotherapy. PG - 583-590 LID - 10.1007/s11920-022-01363-y [doi] AB - PURPOSE OF REVIEW: Few treatments are available for patients with mood disorders or post-traumatic stress disorder (PTSD) who have already failed multiple interventions. After several decades when research into psychedelics was effectively halted by federal legislation, the past several years have shown the re-emergence of thoughtful investigations studying the utility of compounds such as 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin. RECENT FINDINGS: Several studies have coupled the safe administration of psychedelic compounds in a controlled environment after several hours of preparation of study participants and followed by multiple sessions to integrate the psychedelic experience. The improvement participants experience appear related to the often profound perspective changes experienced and seem unlike the improvements seen in the currently available care paradigms. Studies cited include treatment resistant depression, end of life despair, and PTSD. Psychedelic psychotherapy, a unique remarriage of biological therapy and psychotherapy, has the potential to transform mental health care. CI - (c) 2022. The Author(s). FAU - Barber, Gregory S AU - Barber GS AUID- ORCID: 0000-0002-6261-8098 AD - Department of Psychiatry, University of Maryland Medical Center, Baltimore, MD, USA. FAU - Aaronson, Scott T AU - Aaronson ST AD - Institute for Advanced Diagnostics and Therapeutics, Sheppard Pratt Health System, 6501 N. Charles Street, Towson, MD, USA. saaronson@sheppardpratt.org. LA - eng PT - Journal Article PT - Review DEP - 20220921 PL - United States TA - Curr Psychiatry Rep JT - Current psychiatry reports JID - 100888960 RN - 0 (Hallucinogens) RN - 2RV7212BP0 (Psilocybin) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - *Hallucinogens/adverse effects/therapeutic use MH - Humans MH - *N-Methyl-3,4-methylenedioxyamphetamine/therapeutic use MH - Psilocybin/therapeutic use MH - Psychotherapy MH - *Stress Disorders, Post-Traumatic/chemically induced/drug therapy PMC - PMC9553847 OTO - NOTNLM OT - MDMA OT - Psilocybin OT - Psychedelic-assisted therapy OT - Psychedelics OT - Treatment resistant depression COIS- Dr. Barber has no conflicts of interest to report. EDAT- 2022/09/22 06:00 MHDA- 2022/10/14 06:00 PMCR- 2022/09/21 CRDT- 2022/09/21 11:16 PHST- 2022/08/10 00:00 [accepted] PHST- 2022/09/22 06:00 [pubmed] PHST- 2022/10/14 06:00 [medline] PHST- 2022/09/21 11:16 [entrez] PHST- 2022/09/21 00:00 [pmc-release] AID - 10.1007/s11920-022-01363-y [pii] AID - 1363 [pii] AID - 10.1007/s11920-022-01363-y [doi] PST - ppublish SO - Curr Psychiatry Rep. 2022 Oct;24(10):583-590. doi: 10.1007/s11920-022-01363-y. Epub 2022 Sep 21.