PMID- 36131230
OWN - NLM
STAT- MEDLINE
DCOM- 20220923
LR  - 20230324
IS  - 1471-2318 (Electronic)
IS  - 1471-2318 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Sep 21
TI  - Prediction of physical functioning and general health status trajectories on 
      mortality among persons with cognitive impairment.
PG  - 766
LID - 10.1186/s12877-022-03446-0 [doi]
LID - 766
AB  - BACKGROUND: The concern posed by the confluence of aging and cognitive impairment 
      is growing in importance as the U.S. population rapidly ages. As such, we sought 
      to examine the predictive power of physical functioning (PF) and general health 
      status (GHS) trajectories on mortality outcomes among persons with cognitive 
      impairment (PCIs). METHODS: We used group-based trajectory models to identify 
      latent group memberships for PF trajectories in 1,641 PCIs and GHS trajectories 
      in 2,021 PCIs from the National Health and Aging Trends Survey (2011-2018) and 
      applied logistic regressions to predict mortality using these memberships 
      controlling for individual characteristics. RESULTS: We identified six trajectory 
      groups for PF and four groups for GHS. Trajectory group memberships for both 
      outcomes significantly predicted mortality. For PF, group memberships largely 
      captured the average levels over time, and worse trajectories (i.e., lower 
      baselines and faster declines) were associated with higher odds of death. The 
      highest mortality risk was associated with the group experiencing a sharp decline 
      early in its PF trajectory, although its average level across time was not the 
      lowest. For GHS, we observed two groups with comparable average levels across 
      time, but the one with a convex-shape trajectory had much higher mortality risks 
      compared to the one with a concave-shape trajectory. CONCLUSIONS: Our findings 
      highlighted that health trajectories predicted mortality among PCIs, not only 
      because of general levels but also because of the shapes of declines. Close 
      monitoring health deterioration of PCIs is crucial to understand the health 
      burden of this population and to make subsequent actions.
CI  - (c) 2022. The Author(s).
FAU - Zang, Emma
AU  - Zang E
AD  - Department of Sociology, Yale University, New Haven, CT, 06520, USA. 
      emma.zang@yale.edu.
AD  - Department of Biostatistics, Yale University, New Haven, CT, 06520, USA. 
      emma.zang@yale.edu.
FAU - Wang, Xueqing
AU  - Wang X
AD  - Office of Population Research, Princeton University, Princeton, NJ, 08540, USA.
AD  - School of Public and International Affairs, Princeton University, Princeton, NJ, 
      08540, USA.
FAU - Shi, Yu
AU  - Shi Y
AD  - Department of Biostatistics, Yale University, New Haven, CT, 06520, USA.
FAU - Wu, Bei
AU  - Wu B
AD  - Rory Meyers College of Nursing, New York University, New York, NY, 10010, USA.
FAU - Fried, Terri R
AU  - Fried TR
AD  - Veterans Affairs Connecticut Healthcare System, West Haven, CT, 06516, USA.
AD  - Department of Medicine, Yale School of Medicine, New Haven, CT, 06520, USA.
LA  - eng
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - R56 AG067619/AG/NIA NIH HHS/United States
GR  - P30 AG021342/AG/NIA NIH HHS/United States
GR  - R21 AG074238/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220921
PL  - England
TA  - BMC Geriatr
JT  - BMC geriatrics
JID - 100968548
SB  - IM
MH  - Aging/psychology
MH  - *Cognitive Dysfunction/diagnosis
MH  - *Health Status
MH  - Humans
MH  - Logistic Models
MH  - Longitudinal Studies
MH  - Surveys and Questionnaires
PMC - PMC9494770
OTO - NOTNLM
OT  - Cognitive aging
OT  - Health trajectory
OT  - Mortality
OT  - Physical functioning
COIS- The authors declare that they have no competing interests.
EDAT- 2022/09/22 06:00
MHDA- 2022/09/24 06:00
PMCR- 2022/09/21
CRDT- 2022/09/21 23:36
PHST- 2022/05/09 00:00 [received]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2022/09/21 23:36 [entrez]
PHST- 2022/09/22 06:00 [pubmed]
PHST- 2022/09/24 06:00 [medline]
PHST- 2022/09/21 00:00 [pmc-release]
AID - 10.1186/s12877-022-03446-0 [pii]
AID - 3446 [pii]
AID - 10.1186/s12877-022-03446-0 [doi]
PST - epublish
SO  - BMC Geriatr. 2022 Sep 21;22(1):766. doi: 10.1186/s12877-022-03446-0.