PMID- 36131551
OWN - NLM
STAT- MEDLINE
DCOM- 20220923
LR  - 20221011
IS  - 1533-0338 (Electronic)
IS  - 1533-0346 (Print)
IS  - 1533-0338 (Linking)
VI  - 21
DP  - 2022 Jan-Dec
TI  - The Antioxidative Role of Chaperone-Mediated Autophagy as a Downstream Regulator 
      of Oxidative Stress in Human Diseases.
PG  - 15330338221114178
LID - 10.1177/15330338221114178 [doi]
LID - 15330338221114178
AB  - Chaperone-mediated autophagy (CMA) plays an important role in regulating a 
      variety of cellular functions by selectively degrading damaged or functional 
      proteins in the cytoplasm. One of the cellular processes in which CMA 
      participates is the oxidative stress response. Oxidative stress regulates CMA 
      activity, while CMA protects cells from oxidative damage by degrading oxidized 
      proteins and preventing the accumulation of excessive reactive oxygen species 
      (ROS). Changes in CMA activity have been found in many human diseases, and 
      oxidative stress is also involved. Therefore, understanding the interaction 
      mechanism of ROS and CMA will provide new targets for disease treatment. In this 
      review, we discuss the role of CMA in combatting oxidative stress during the 
      development of different conditions, such as aging, neurodegeneration, liver 
      diseases, infections, pulmonary disorders, and cancers.
FAU - Le, Shuangshuang
AU  - Le S
AUID- ORCID: 0000-0003-3431-8458
AD  - Guangxi Key Laboratory of Bio-Targeting Theranostics, National Center for 
      International Research of Bio-Targeting Theranostics, Collaborative Innovation 
      Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of 
      Bio-Targeting Theranostics, 74626Guangxi Medical University, Nanning, China.
AD  - State Key Laboratory of Cancer Biology, National Clinical Research Center for 
      Digestive Diseases and Xijing Hospital of Digestive Diseases, 12644Air Force 
      Military Medical University, Xi'an, China.
FAU - Fu, Xin
AU  - Fu X
AD  - Guangxi Key Laboratory of Bio-Targeting Theranostics, National Center for 
      International Research of Bio-Targeting Theranostics, Collaborative Innovation 
      Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of 
      Bio-Targeting Theranostics, 74626Guangxi Medical University, Nanning, China.
AD  - State Key Laboratory of Cancer Biology, National Clinical Research Center for 
      Digestive Diseases and Xijing Hospital of Digestive Diseases, 12644Air Force 
      Military Medical University, Xi'an, China.
FAU - Pang, Maogui
AU  - Pang M
AD  - State Key Laboratory of Cancer Biology, National Clinical Research Center for 
      Digestive Diseases and Xijing Hospital of Digestive Diseases, 12644Air Force 
      Military Medical University, Xi'an, China.
FAU - Zhou, Yao
AU  - Zhou Y
AD  - Guangxi Key Laboratory of Bio-Targeting Theranostics, National Center for 
      International Research of Bio-Targeting Theranostics, Collaborative Innovation 
      Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of 
      Bio-Targeting Theranostics, 74626Guangxi Medical University, Nanning, China.
AD  - State Key Laboratory of Cancer Biology, National Clinical Research Center for 
      Digestive Diseases and Xijing Hospital of Digestive Diseases, 12644Air Force 
      Military Medical University, Xi'an, China.
FAU - Yin, Guoqing
AU  - Yin G
AD  - Department of Oncology, 572481Xianyang Hospital of Yan'an University, Xianyang, 
      China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Department of Oncology, 572481Xianyang Hospital of Yan'an University, Xianyang, 
      China.
FAU - Fan, Daiming
AU  - Fan D
AD  - Guangxi Key Laboratory of Bio-Targeting Theranostics, National Center for 
      International Research of Bio-Targeting Theranostics, Collaborative Innovation 
      Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of 
      Bio-Targeting Theranostics, 74626Guangxi Medical University, Nanning, China.
AD  - State Key Laboratory of Cancer Biology, National Clinical Research Center for 
      Digestive Diseases and Xijing Hospital of Digestive Diseases, 12644Air Force 
      Military Medical University, Xi'an, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Technol Cancer Res Treat
JT  - Technology in cancer research & treatment
JID - 101140941
RN  - 0 (Antioxidants)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - *Antioxidants/metabolism
MH  - Autophagy/genetics
MH  - *Chaperone-Mediated Autophagy
MH  - Humans
MH  - Lysosomes/metabolism
MH  - Molecular Chaperones/metabolism
MH  - Oxidative Stress
MH  - Reactive Oxygen Species/metabolism
PMC - PMC9500268
OTO - NOTNLM
OT  - autophagy
OT  - immunity
OT  - metabolism
OT  - neurodegeneration
OT  - pulmonary disease
OT  - reactive oxygen species
OT  - tumor
COIS- Declaration of Conflicting Interests: The authors declared no potential conflicts 
      of interest with respect to the research, authorship, and/or publication of this 
      article.
EDAT- 2022/09/23 06:00
MHDA- 2022/09/24 06:00
PMCR- 2022/09/21
CRDT- 2022/09/22 01:52
PHST- 2022/09/22 01:52 [entrez]
PHST- 2022/09/23 06:00 [pubmed]
PHST- 2022/09/24 06:00 [medline]
PHST- 2022/09/21 00:00 [pmc-release]
AID - 10.1177_15330338221114178 [pii]
AID - 10.1177/15330338221114178 [doi]
PST - ppublish
SO  - Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221114178. doi: 
      10.1177/15330338221114178.