PMID- 36133925
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220924
IS  - 1179-156X (Print)
IS  - 1179-156X (Electronic)
IS  - 1179-156X (Linking)
VI  - 14
DP  - 2022
TI  - Silent Lupus Nephritis: Renal Histopathological Profile and Early Detection with 
      Urinary Monocyte Chemotactic Protein 1.
PG  - 161-170
LID - 10.2147/OARRR.S373589 [doi]
AB  - OBJECTIVE: Lupus nephritis (LN) affects almost half of all individuals with 
      systemic lupus erythematosus (SLE). Overt LN (OLN) symptoms might vary from 
      asymptomatic microscopic hematuria to renal failure. However, when there are no 
      clinical or laboratory indicators of renal involvement, some people with silent 
      LN (SLN) may have pathological evidence of renal involvement identified by renal 
      biopsy. Monocyte Chemotactic Protein 1 (MCP-1) is a chemotactic factor that 
      promotes leukocyte migration to the kidney. MCP-1 urine levels (uMCP-1) have been 
      demonstrated to be high in individuals with active LN. The purpose of this study 
      was to discover the occurrence of SLN, as well as the possible variations between 
      overt LN (OLN) and SLN across SLE patients based on the histopathological 
      assessment, as well as the role of uMCP-1 in the early detection of SLN. METHODS: 
      An overall of 144 patients with SLE were included in the current research. 
      Patients were subsequently divided into two groups: individuals who did not have 
      clinical evidence of LN (84 patients) and those with OLN (60 patients). All the 
      patients were subjected to the following investigations: uMCP-1, erythrocyte 
      sedimentation rate (ESR), complement C3 (C3), complement C4 (C4), creatinine, 
      albumin/creatinine ratio (uACR), creatinine clearance, quantitative assessment of 
      proteinuria by 24-hour urine proteinuria (24hr UP) and percutaneous renal biopsy. 
      RESULTS: Sixty patients from group I (71.4%) showed glomerular lesions on renal 
      biopsy (SLN), and class II was the predominant class. uMCP-1 had a sensitivity of 
      95.2% and a specificity of 98% in the detection of SLN, and uMCP-1 values were 
      markedly higher in patients with OLN in comparison to SLN. CONCLUSION: The actual 
      frequency of SLN may be higher than expected. High levels of uMCP-1 may have 
      warranted the early activity of LN. uMCP-1 can be used as a non-invasive, useful 
      tool for the prediction of LN.
CI  - (c) 2022 Gouda et al.
FAU - Gouda, Wesam
AU  - Gouda W
AUID- ORCID: 0000-0001-6753-3811
AD  - Department of Rheumatology, Faculty of Medicine, Al Azhar University, Assiut, 
      Egypt.
FAU - Abd Elaziz Alsaid, Aldosoky
AU  - Abd Elaziz Alsaid A
AD  - Department of Internal Medicine, Faculty of Medicine, Al Azhar University, 
      Assiut, Egypt.
FAU - Abbas, Awad Saad
AU  - Abbas AS
AD  - Department of Rheumatology, Faculty of Medicine, Al Azhar University, Assiut, 
      Egypt.
FAU - Abdel-Aziz, Tarek M
AU  - Abdel-Aziz TM
AUID- ORCID: 0000-0002-2934-7038
AD  - Department of Rheumatology, Faculty of Medicine, Al Azhar University, Assiut, 
      Egypt.
FAU - Shoaeir, Mohamed Z
AU  - Shoaeir MZ
AD  - Department of Rheumatology, Faculty of Medicine, Al Azhar University, Assiut, 
      Egypt.
FAU - Abd Elazem, Abd Allah S
AU  - Abd Elazem AAS
AD  - Department of Medical Biochemistry, Faculty of Medicine, Suez University, Suez, 
      Egypt.
FAU - Sayed, Mohammad Hamdy
AU  - Sayed MH
AD  - Department of Pathology, Faculty of Medicine, Al Azhar University, Assiut, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20220914
PL  - New Zealand
TA  - Open Access Rheumatol
JT  - Open access rheumatology : research and reviews
JID - 101688698
PMC - PMC9482965
OTO - NOTNLM
OT  - overt lupus nephritis
OT  - renal biopsy
OT  - silent lupus-nephritis
OT  - systemic lupus erythematosus
OT  - urinary chemotactic protein 1
COIS- The authors declare that they have no competing interests.
EDAT- 2022/09/23 06:00
MHDA- 2022/09/23 06:01
PMCR- 2022/09/14
CRDT- 2022/09/22 04:03
PHST- 2022/05/06 00:00 [received]
PHST- 2022/08/24 00:00 [accepted]
PHST- 2022/09/22 04:03 [entrez]
PHST- 2022/09/23 06:00 [pubmed]
PHST- 2022/09/23 06:01 [medline]
PHST- 2022/09/14 00:00 [pmc-release]
AID - 373589 [pii]
AID - 10.2147/OARRR.S373589 [doi]
PST - epublish
SO  - Open Access Rheumatol. 2022 Sep 14;14:161-170. doi: 10.2147/OARRR.S373589. 
      eCollection 2022.