PMID- 36134184 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220924 IS - 2516-0230 (Electronic) IS - 2516-0230 (Linking) VI - 3 IP - 10 DP - 2021 May 18 TI - Self-assembled anionic and cationic Au nanoparticles with Au nanoclusters for the exploration of different biological responsiveness in cancer therapy. PG - 2812-2821 LID - 10.1039/d0na01066a [doi] AB - Self-assembly overcomes the biodegradation resistance of some traditional inorganic drug carriers. Herein, we prepared self-assembled Au nanocluster-based nanoparticles with different sizes and charges based on solvent- and cation-induced self-assembly nanotechnology as anti-cancer drug vehicles to solve the potential metabolism problems of solid gold nanoparticles. We also systematically explored the responsiveness of cancer cells to self-assembled Au nanocluster-based nanoparticles with different sizes and surface modified properties. We discovered that self-assembled nanoparticles inherited molecular-like properties of small-size Au NCs and exhibited an aggregation-induced emission (AIE) phenomenon with intense luminescence. Self-assembled Au nanocluster-based nanoparticles (Au NPs and cAu NPs) taking advantage of their size and positive charge exhibited better cell uptake than Au NCs. Encouraged by the excellent biological compatibility and cell uptake of these nanomaterials, we prepared drug-loaded nanomaterials by diffusion absorption and hydrophobic-induced embedding. cAu NPs@DOX showed an excellent anti-cancer effect owing to efficient cell internalization; Au NPs@DOX exhibited slow release of cargo drugs which might be significant to in vivo drug delivery. This work plays a crucial role in the rational design of self-assembled multifunctional gold-based nanoparticles in the application of nanomaterial-assisted multifunctional drug delivery systems (DDSs). CI - This journal is (c) The Royal Society of Chemistry. FAU - Yang, Jingjing AU - Yang J AD - Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University Jinan Shandong China lihuilmy@hotmail.com yanyan.jiang@sdu.edu.cn. FAU - Zhang, Lu AU - Zhang L AD - Institute of Medical Sciences, The Second Hospital of Shandong University 247 Beiyuan Dajie Street Jinan Shandong China lyuanhq@sdu.edu.cn. FAU - Zhou, Qian AU - Zhou Q AD - Department of Obstetrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University 324 Jingwu Street Jinan Shandong China. FAU - Chen, Fan AU - Chen F AD - Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales Sydney NSW 2052 Australia. FAU - Stenzel, Martina AU - Stenzel M AUID- ORCID: 0000-0002-6433-4419 AD - Centre for Advanced Macromolecular Design (CAMD), School of Chemistry, University of New South Wales Sydney NSW 2052 Australia. FAU - Gao, Fucheng AU - Gao F AD - Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University Jinan Shandong China lihuilmy@hotmail.com yanyan.jiang@sdu.edu.cn. FAU - Liu, Chao AU - Liu C AD - Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine Shanghai China. FAU - Yuan, Huiqing AU - Yuan H AD - Institute of Medical Sciences, The Second Hospital of Shandong University 247 Beiyuan Dajie Street Jinan Shandong China lyuanhq@sdu.edu.cn. FAU - Li, Hui AU - Li H AUID- ORCID: 0000-0002-1457-8650 AD - Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University Jinan Shandong China lihuilmy@hotmail.com yanyan.jiang@sdu.edu.cn. FAU - Jiang, Yanyan AU - Jiang Y AUID- ORCID: 0000-0002-7866-4689 AD - Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University Jinan Shandong China lihuilmy@hotmail.com yanyan.jiang@sdu.edu.cn. AD - Suzhou Institute of Shandong University Room 522, Building H of NUSP, NP.388 Ruoshui Road, SIP Suzhou Jiangsu China. AD - Shenzhen Research Institute of Shandong University Shenzhen Guangdong China. LA - eng PT - Journal Article DEP - 20210308 PL - England TA - Nanoscale Adv JT - Nanoscale advances JID - 101738708 PMC - PMC9417972 COIS- There are no conflicts to declare. EDAT- 2021/03/08 00:00 MHDA- 2021/03/08 00:01 PMCR- 2021/03/08 CRDT- 2022/09/22 04:07 PHST- 2020/12/22 00:00 [received] PHST- 2021/03/07 00:00 [accepted] PHST- 2022/09/22 04:07 [entrez] PHST- 2021/03/08 00:00 [pubmed] PHST- 2021/03/08 00:01 [medline] PHST- 2021/03/08 00:00 [pmc-release] AID - d0na01066a [pii] AID - 10.1039/d0na01066a [doi] PST - epublish SO - Nanoscale Adv. 2021 Mar 8;3(10):2812-2821. doi: 10.1039/d0na01066a. eCollection 2021 May 18.