PMID- 36134459
OWN - NLM
STAT- MEDLINE
DCOM- 20221121
LR  - 20221226
IS  - 1473-4877 (Electronic)
IS  - 0300-7995 (Linking)
VI  - 38
IP  - 11
DP  - 2022 Nov
TI  - Impact of cardiovascular disease on health care economic burden and resource 
      utilization: a retrospective cohort study in adults in the United States with 
      type 2 diabetes with or without stroke, myocardial infarction, and peripheral 
      arterial disease.
PG  - 1831-1840
LID - 10.1080/03007995.2022.2125259 [doi]
AB  - OBJECTIVES: To evaluate incidence of stroke, myocardial infarction (MI), and 
      peripheral artery disease (PAD) in patients with type 2 diabetes mellitus (T2DM) 
      and assess associated health care resource utilization (HCRU) and costs in the 
      United States. METHODS: Patients >/=18 years of age with a T2DM diagnosis, with or 
      without incident stroke/MI/PAD, were indexed between 1 January 2012 and 31 
      December 2020, from the deidentified Optum Clinformatics Data Mart claims 
      database. Incidence of stroke, MI, and PAD was evaluated in the year following 
      T2DM. HCRU and costs were measured in the 12 months following study entry in 
      patients with T2DM + stroke, T2DM + MI, and T2DM + PAD (experimental cohorts) and 
      compared to HCRU and costs in patients with T2DM alone (control cohorts). 
      RESULTS: Incidence of stroke, MI, and PAD in patients with T2DM was 0.9% 
      (n = 16,034), 0.7% (n = 13,681), and 4.1% (n = 68,479), respectively. Compared to 
      matched patients with T2DM alone, patients with T2DM + stroke/MI/PAD had 
      significantly higher total healthcare costs in the year post-index date 
      (T2DM + stroke: +$5962 per patient per month [PPPM]; T2DM + MI: +$7932 PPPM; 
      T2DM + PAD: +$2652 PPPM; p < .05). Patients with T2DM + stroke/MI/PAD had 
      significantly higher mean HCRU than patients without stroke/MI/PAD in all 
      categories measured. CONCLUSION: Having stroke, MI, or PAD was associated with 
      increases in HCRU and costs in patients with T2DM. Although PAD was associated 
      with smaller per patient increases in total healthcare costs than patients with 
      T2DM + stroke/MI, the higher frequency of incident PAD may make it more costly 
      than MI or stroke in a large population of patients with T2DM.
FAU - King, Aaron
AU  - King A
AD  - MedFirst Primary Care, San Antonio, TX, USA.
FAU - Rajpura, Jigar
AU  - Rajpura J
AD  - Novo Nordisk, Inc., Plainsboro, NJ, USA.
FAU - Liang, Yuanjie
AU  - Liang Y
AD  - Novo Nordisk, Inc., Plainsboro, NJ, USA.
FAU - Paprocki, Yurek
AU  - Paprocki Y
AD  - Novo Nordisk, Inc., Plainsboro, NJ, USA.
FAU - Uzoigwe, Chioma
AU  - Uzoigwe C
AD  - Novo Nordisk, Inc., Plainsboro, NJ, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220929
PL  - England
TA  - Curr Med Res Opin
JT  - Current medical research and opinion
JID - 0351014
SB  - IM
MH  - Adult
MH  - United States/epidemiology
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - *Cardiovascular Diseases/epidemiology
MH  - Retrospective Studies
MH  - Financial Stress
MH  - *Myocardial Infarction/epidemiology
MH  - *Stroke/epidemiology
MH  - Health Care Costs
MH  - *Peripheral Arterial Disease/complications/epidemiology
OAB - Compared to patients without type 2 diabetes (T2D), patients with T2D have a 
      greater chance of having a stroke, heart attack, and narrowing of blood vessels 
      in the arms and legs (peripheral artery disease [PAD]). A stroke, heart attack, 
      or PAD may lead to hospitalization or death. We sought to understand healthcare 
      usage (hospital visits, emergency room visits, office visits, etc.) and costs 
      associated with stroke, heart attack, and PAD in patients with T2D in the United 
      States. Healthcare resource usage and costs were estimated by using data from 
      health insurance claims to compare healthcare usage and costs among patients with 
      T2D, some of whom had a stroke, heart attack, or PAD, and some who did not. 
      Compared to patients with T2D without stroke/heart attack/PAD, patients with T2D 
      and stroke/heart attack/PAD had more overnight hospital visits, doctors' office 
      visits, and emergency room visits. Patients with T2D and stroke/heart attack/PAD 
      also had longer hospital stays. Patients with T2D and stroke/heart attack/PAD all 
      had higher total healthcare costs in the year following their diagnoses, compared 
      to patients with T2D without stroke/heart attack/PAD. By highlighting the greater 
      costs and use of healthcare associated with stroke, heart attack, and PAD in 
      patients with T2D, we hope to encourage more preventative management of stroke, 
      heart attack, and PAD in patients with T2D.
OABL- eng
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - cerebrovascular disorders
OT  - cost of illness
OT  - endocrine system diseases
OT  - health care costs
EDAT- 2022/09/23 06:00
MHDA- 2022/11/22 06:00
CRDT- 2022/09/22 04:13
PHST- 2022/09/23 06:00 [pubmed]
PHST- 2022/11/22 06:00 [medline]
PHST- 2022/09/22 04:13 [entrez]
AID - 10.1080/03007995.2022.2125259 [doi]
PST - ppublish
SO  - Curr Med Res Opin. 2022 Nov;38(11):1831-1840. doi: 10.1080/03007995.2022.2125259. 
      Epub 2022 Sep 29.