PMID- 36135777
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20221205
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 25
IP  - 12
DP  - 2022 Dec
TI  - Factors associated with cytomegalovirus infection in antineutrophil cytoplasmic 
      antibody-associated vasculitis: A narrative review.
PG  - 1357-1367
LID - 10.1111/1756-185X.14444 [doi]
AB  - Patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV) are 
      vulnerable to opportunistic infections, including cytomegalovirus (CMV) 
      infection. This narrative review aims to identify factors associated with CMV 
      infection in patients with AAV. The literature review was conducted on Cumulative 
      Index to Nursing and Allied Health Literature (CINAHL), Cochrane, PubMed, Scopus, 
      and Web of Science. The start date of the literature search was unrestricted and 
      the end date was February 2022. CMV infection was defined as (a) CMV pp65 
      antigenemia or positive CMV DNA viral load by polymerase chain reaction or CMV 
      detection on histological specimens, with associated signs and symptoms 
      compatible with CMV infection; (b) presence of CMV clinical syndrome (defined as 
      presence of compatible symptoms and signs and documentation of CMV by biopsy by 
      virus isolation, rapid culture, immunohistochemistry, or DNA in biopsy material 
      as defined by the CMV Drug Development Forum); and (c) CMV infection as coded by 
      the International Statistical Classification of Diseases and Related Health 
      Problems, 10th revision with at least one prescription for CMV treatment. We 
      identified 4505 articles, of which three (2327 patients with AAV) were included. 
      All studies were retrospective and only one of the three studies included only 
      patients with AAV. Low or decreasing lymphocyte counts and higher prednisolone 
      usage were associated with CMV infection in patients with AAV. Patients with AAV 
      with lymphopenia and on high doses of prednisolone should be monitored closely 
      for signs and symptoms of CMV infection, and might benefit from CMV prophylaxis. 
      Prospective studies are urgently needed to better identify causes of CMV 
      infections in patients with AAV.
CI  - (c) 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Leong, Ashley
AU  - Leong A
AUID- ORCID: 0000-0001-5906-0831
AD  - Department of Rheumatology and Immunology, Singapore General Hospital, Singapore 
      City, Singapore.
FAU - Fong, Warren
AU  - Fong W
AUID- ORCID: 0000-0003-1891-1892
AD  - Department of Rheumatology and Immunology, Singapore General Hospital, Singapore 
      City, Singapore.
AD  - Duke-NUS Medical School, Singapore City, Singapore.
AD  - Department of Medicine, Yong Loo Lin School of Medicine, National University of 
      Singapore, Singapore City, Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220922
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Humans
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Retrospective Studies
MH  - Prospective Studies
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis/drug 
      therapy/pathology
MH  - *Cytomegalovirus Infections/diagnosis/drug therapy/epidemiology
MH  - Prednisolone/therapeutic use
OTO - NOTNLM
OT  - ANCA
OT  - antibodies
OT  - antineutrophil cytoplasmic antibody-associated vasculitis
OT  - cytomegalovirus
OT  - granulomatosis with polyangiitis
OT  - opportunistic infections
EDAT- 2022/09/23 06:00
MHDA- 2022/12/06 06:00
CRDT- 2022/09/22 09:23
PHST- 2022/08/08 00:00 [revised]
PHST- 2022/05/27 00:00 [received]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2022/09/23 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
PHST- 2022/09/22 09:23 [entrez]
AID - 10.1111/1756-185X.14444 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2022 Dec;25(12):1357-1367. doi: 10.1111/1756-185X.14444. Epub 
      2022 Sep 22.