PMID- 36137277
OWN - NLM
STAT- MEDLINE
DCOM- 20230214
LR  - 20240305
IS  - 1545-1585 (Electronic)
IS  - 0066-4278 (Print)
IS  - 0066-4278 (Linking)
VI  - 85
DP  - 2023 Feb 10
TI  - Iron and the Pathophysiology of Diabetes.
PG  - 339-362
LID - 10.1146/annurev-physiol-022522-102832 [doi]
AB  - High iron is a risk factor for type 2 diabetes mellitus (T2DM) and affects most 
      of its cardinal features: decreased insulin secretion, insulin resistance, and 
      increased hepatic gluconeogenesis. This is true across the normal range of tissue 
      iron levels and in pathologic iron overload. Because of iron's central role in 
      metabolic processes (e.g., fuel oxidation) and metabolic regulation (e.g., 
      hypoxia sensing), iron levels participate in determining metabolic rates, 
      gluconeogenesis, fuel choice, insulin action, and adipocyte phenotype. The risk 
      of diabetes related to iron is evident in most or all tissues that determine 
      diabetes phenotypes, with the adipocyte, beta cell, and liver playing central 
      roles. Molecular mechanisms for these effects are diverse, although there may be 
      integrative pathways at play. Elucidating these pathways has implications not 
      only for diabetes prevention and treatment, but also for the pathogenesis of 
      other diseases that are, like T2DM, associated with aging, nutrition, and iron.
FAU - Harrison, Alexandria V
AU  - Harrison AV
AD  - Department of Internal Medicine, Wake Forest University School of Medicine, 
      Winston-Salem, North Carolina, USA; email: dmcclain@wakehealth.edu.
FAU - Lorenzo, Felipe Ramos
AU  - Lorenzo FR
AD  - Department of Internal Medicine, Wake Forest University School of Medicine, 
      Winston-Salem, North Carolina, USA; email: dmcclain@wakehealth.edu.
AD  - Department of Veterans Affairs, W.G. (Bill) Hefner Veterans Affairs Medical 
      Center, Salisbury, North Carolina, USA.
FAU - McClain, Donald A
AU  - McClain DA
AD  - Department of Internal Medicine, Wake Forest University School of Medicine, 
      Winston-Salem, North Carolina, USA; email: dmcclain@wakehealth.edu.
AD  - Department of Veterans Affairs, W.G. (Bill) Hefner Veterans Affairs Medical 
      Center, Salisbury, North Carolina, USA.
LA  - eng
GR  - I01 BX005109/BX/BLRD VA/United States
GR  - I01 BX001140/BX/BLRD VA/United States
GR  - P30 DK124723/DK/NIDDK NIH HHS/United States
GR  - R01 DK119913/DK/NIDDK NIH HHS/United States
GR  - UL1 TR001420/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20220922
PL  - United States
TA  - Annu Rev Physiol
JT  - Annual review of physiology
JID - 0370600
RN  - E1UOL152H7 (Iron)
SB  - IM
CIN - Front Endocrinol (Lausanne). 2023 Dec 15;14:1298101. PMID: 38161979
MH  - Humans
MH  - Iron/metabolism
MH  - *Diabetes Mellitus, Type 2
MH  - *Iron Overload/complications/metabolism
MH  - Liver/metabolism
MH  - *Insulin Resistance/physiology
PMC - PMC10161568
MID - NIHMS1889793
OTO - NOTNLM
OT  - adipocyte
OT  - diabetes
OT  - hemochromatosis
OT  - hepcidin
OT  - insulin
OT  - iron
EDAT- 2022/09/23 06:00
MHDA- 2023/02/15 06:00
PMCR- 2023/05/05
CRDT- 2022/09/22 17:02
PHST- 2022/09/23 06:00 [pubmed]
PHST- 2023/02/15 06:00 [medline]
PHST- 2022/09/22 17:02 [entrez]
PHST- 2023/05/05 00:00 [pmc-release]
AID - 10.1146/annurev-physiol-022522-102832 [doi]
PST - ppublish
SO  - Annu Rev Physiol. 2023 Feb 10;85:339-362. doi: 
      10.1146/annurev-physiol-022522-102832. Epub 2022 Sep 22.