PMID- 36137411
OWN - NLM
STAT- MEDLINE
DCOM- 20221018
LR  - 20231213
IS  - 2352-3964 (Electronic)
IS  - 2352-3964 (Linking)
VI  - 84
DP  - 2022 Oct
TI  - Dermal thirdhand smoke exposure induces oxidative damage, initiates skin 
      inflammatory markers, and adversely alters the human plasma proteome.
PG  - 104256
LID - S2352-3964(22)00438-8 [pii]
LID - 10.1016/j.ebiom.2022.104256 [doi]
LID - 104256
AB  - BACKGROUND: Thirdhand smoke (THS) exposure correlated with significant metabolism 
      of carcinogenic chemicals and the potential to cause detrimental health effects. 
      Human harm research of THS exposure is limited to one other study and overall, 
      there is a general lack of knowledge of the human health responses to THS 
      exposure. METHODS: This was a clinical investigation to evaluate the health 
      effects of 3-h dermal THS exposure from urine and plasma. 10 healthy, non-smoking 
      subjects were recruited for dermal exposure for 3 h exposed to clothing 
      impregnated with filtered clean air or THS. Exposures to clean air or THS 
      occurred 20-30 days apart. FINDINGS: In THS-exposed group, there was a 
      significant elevation of urinary 8-OHdG, 8-isoprostane, protein carbonyls. The 
      THS 3-h exposure identified proteomics pathways of inflammatory response 
      (p=2.18 x 10(-8)), adhesion of blood cells (p=2.23 x 10(-8)), atherosclerosis 
      (p=2.78 x 10(-9)), and lichen planus (p=1.77 x 10(-8)). Nine canonical pathways 
      were significantly activated including leukocyte extravasation signaling 
      (z-score=3.0), and production of nitric oxide and reactive oxygen in macrophages 
      (z-score=2.1). The THS 22-h proteomics pathways revealed inflammation of organ 
      (p=3.09 x 10(-8)), keratinization of the epidermis (p=4.0 x 10(-7)), plaque 
      psoriasis (p=5.31 x 10(-7)), and dermatitis (p=6.0 x 10(-7)). Two activated 
      canonical pathways were production of nitric oxide and reactive oxygen in 
      macrophages (z-score=2.646), and IL-8 signaling (z-score=2.0). INTERPRETATION: 
      This is a clinical study demonstrating that acute dermal exposure to THS mimics 
      the harmful effects of cigarette smoking, alters the human plasma proteome, 
      initiates mechanisms of skin inflammatory disease, and elevates urinary 
      biomarkers of oxidative harm. FUNDING: Funding was provided by the Tobacco 
      Related Disease Research Program (TRDRP) 24RT-0037 TRDRP, 24RT-0039 TRDRP, and 
      28PT-0081 TRDRP.
CI  - Copyright (c) 2022. Published by Elsevier B.V.
FAU - Sakamaki-Ching, Shane
AU  - Sakamaki-Ching S
AD  - Department of Molecular, Cell, and Systems Biology, University of California, 
      Riverside, United States.
FAU - Schick, Suzaynn
AU  - Schick S
AD  - Center for Tobacco Control Research and Education, University of California, San 
      Francisco, United States.
FAU - Grigorean, Gabriela
AU  - Grigorean G
AD  - Proteomics Core Facility, University of California, Davis, United States.
FAU - Li, Jun
AU  - Li J
AD  - Department of Statistics, University of California, Riverside, United States.
FAU - Talbot, Prue
AU  - Talbot P
AD  - Department of Molecular, Cell, and Systems Biology, University of California, 
      Riverside, United States. Electronic address: talbot@ucr.edu.
LA  - eng
PT  - Journal Article
DEP - 20220919
PL  - Netherlands
TA  - EBioMedicine
JT  - EBioMedicine
JID - 101647039
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-8)
RN  - 0 (Proteome)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Biomarkers
MH  - Humans
MH  - Interleukin-8
MH  - Nitric Oxide/pharmacology
MH  - Oxidative Stress
MH  - Oxygen
MH  - Proteome
MH  - Nicotiana
MH  - *Tobacco Smoke Pollution/adverse effects
PMC - PMC9494172
OTO - NOTNLM
OT  - Biomarkers
OT  - Inflammation
OT  - Oxidative stress
OT  - Proteomics
OT  - Skin disease
OT  - Thirdhand smoke
COIS- Declaration of interests The authors did not receive direct funding for this 
      project. Funding from TRDRP was administered via the institution. All authors 
      declare no direct support from any organization for the submitted work, no 
      financial relationships with any organizations that might have an interest in the 
      submitted work in the previous three years, and no other relationships or 
      activities that could appear to have influenced the submitted work.
EDAT- 2022/09/23 06:00
MHDA- 2022/10/19 06:00
PMCR- 2022/09/19
CRDT- 2022/09/22 18:20
PHST- 2022/03/02 00:00 [received]
PHST- 2022/07/16 00:00 [revised]
PHST- 2022/08/22 00:00 [accepted]
PHST- 2022/09/23 06:00 [pubmed]
PHST- 2022/10/19 06:00 [medline]
PHST- 2022/09/22 18:20 [entrez]
PHST- 2022/09/19 00:00 [pmc-release]
AID - S2352-3964(22)00438-8 [pii]
AID - 104256 [pii]
AID - 10.1016/j.ebiom.2022.104256 [doi]
PST - ppublish
SO  - EBioMedicine. 2022 Oct;84:104256. doi: 10.1016/j.ebiom.2022.104256. Epub 2022 Sep 
      19.