PMID- 36137816
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20220926
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 41
DP  - 2022 Jan-Dec
TI  - Gestational bisphenol A exposure impairs hepatic lipid metabolism by altering 
      mTOR/CRTC2/SREBP1 in male rat offspring.
PG  - 9603271221129852
LID - 10.1177/09603271221129852 [doi]
AB  - Lipid metabolism is an important biochemical process in the body. Recent studies 
      have found that environmental endocrine disruptors play an important role in the 
      regulation of lipid metabolism. Bisphenol A (BPA), a common environmental 
      endocrine disruptor, has adverse effects on lipid metabolism, but the mechanism 
      is still unclear. This study aimed to investigate the effects of gestational BPA 
      exposure on hepatic lipid metabolism and its possible mechanism in male 
      offspring. The pregnant Sprague-Dawley rats were exposed to BPA (0, 0.05, 0.5, 
      5 mg/kg/day) from day 5 to day 19 of gestation to investigate the levels of 
      triglyceride (TG) and total cholesterol (TC), and the expression of liver lipid 
      metabolism-related genes in male offspring rats. The results showed that compared 
      with the control group, the TG and TC levels in serum and liver in BPA-exposed 
      groups was increased. And the expressions of liver fatty acid oxidation related 
      genes, such as peroxisome proliferators-activated receptor alpha (PPARalpha) and 
      carnitine palmitoyl transferase 1alpha (CPT1alpha), were down-regulated. However, the 
      expressions of fatty acid synthesis related genes, such as sterol regulatory 
      element binding proteins 1 (SREBP-1), acetyl-CoA carboxylase 1 (ACC1), fatty acid 
      synthase (FAS) and stearoyl-CoA desaturase 1 (SCD-1), were up-regulated. The 
      increased protein levels of mTOR and p-CRTC2 suggested that CREB-regulated 
      transcription coactivator 2 (CRTC2) might be an important mediator in the 
      mTOR/SREBP-1 pathway. In conclusion, these results demonstrated that 
      mTOR/CRTC2/SREBP-1 could be affected by gestational BPA exposure, which may 
      involve in the lipid metabolic disorders in later life.
FAU - Yang, Q
AU  - Yang Q
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
FAU - Mao, Y
AU  - Mao Y
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
FAU - Wang, J
AU  - Wang J
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
FAU - Yu, H
AU  - Yu H
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
FAU - Zhang, X
AU  - Zhang X
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
FAU - Pei, X
AU  - Pei X
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
FAU - Duan, Z
AU  - Duan Z
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
FAU - Xiao, C
AU  - Xiao C
AD  - Department of Key Laboratory of Environmental Pollution and Microecology, 
      70577Shenyang Medical College, Shenyang, China.
FAU - Ma, M
AU  - Ma M
AUID- ORCID: 0000-0003-4440-1618
AD  - Department of Toxicology, School of Public Heath, 70577Shenyang Medical College, 
      Shenyang, China.
AD  - Department of Key Laboratory of Environmental Pollution and Microecology, 
      70577Shenyang Medical College, Shenyang, China.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Fatty Acids)
RN  - 0 (PPAR alpha)
RN  - 0 (Peroxisome Proliferators)
RN  - 0 (Phenols)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.14.19.1 (Stearoyl-CoA Desaturase)
RN  - EC 2.- (Transferases)
RN  - EC 2.3.1.85 (Fatty Acid Synthases)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - EC 6.4.1.2 (Acetyl-CoA Carboxylase)
RN  - MLT3645I99 (bisphenol A)
RN  - S7UI8SM58A (Carnitine)
SB  - IM
MH  - Acetyl-CoA Carboxylase/metabolism/pharmacology
MH  - Animals
MH  - Benzhydryl Compounds
MH  - Carnitine/pharmacology
MH  - Cholesterol
MH  - *Endocrine Disruptors/toxicity
MH  - Fatty Acid Synthases/metabolism/pharmacology
MH  - Fatty Acids/pharmacology
MH  - Female
MH  - *Lipid Metabolism
MH  - Liver
MH  - Male
MH  - PPAR alpha/metabolism
MH  - Peroxisome Proliferators/metabolism/pharmacology
MH  - Phenols
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stearoyl-CoA Desaturase/metabolism/pharmacology
MH  - Sterol Regulatory Element Binding Protein 1/genetics/metabolism/pharmacology
MH  - TOR Serine-Threonine Kinases/metabolism
MH  - Transferases/metabolism/pharmacology
MH  - Triglycerides
OTO - NOTNLM
OT  - CRTC2
OT  - Gestational BPA exposure
OT  - SREBP-1
OT  - lipid metabolism
OT  - mTOR
OT  - male offspring
EDAT- 2022/09/23 06:00
MHDA- 2022/09/28 06:00
CRDT- 2022/09/22 22:03
PHST- 2022/09/22 22:03 [entrez]
PHST- 2022/09/23 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
AID - 10.1177/09603271221129852 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221129852. doi: 
      10.1177/09603271221129852.