PMID- 36138998
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 12
IP  - 9
DP  - 2022 Sep 17
TI  - Temporal Stability of Dynamic Default Mode Network Connectivity Negatively 
      Correlates with Suicidality in Major Depressive Disorder.
LID - 10.3390/brainsci12091263 [doi]
LID - 1263
AB  - Previous studies have demonstrated that the suicidality in patients with major 
      depressive disorder (MDD) is related to abnormal brain functional connectivity 
      (FC) patterns. However, little is known about its relationship with dynamic 
      functional connectivity (dFC) based on the assumption that brain FCs fluctuate 
      over time. Temporal stabilities of dFCs within the whole brain and nine key 
      networks were compared between 52 MDD patients and 21 age, sex-matched healthy 
      controls (HCs) using resting-state functional magnetic resonance imaging and 
      temporal correlation coefficients. The alterations in MDD were further correlated 
      with the scores of suicidality item in the Hamilton Rating Scale for Depression 
      (HAMD). Compared with HCs, the MDD patients showed a decreased temporal stability 
      of dFC as indicated by a significantly decreased temporal correlation coefficient 
      at the global level, as well as within the default mode network (DMN) and 
      subcortical network. In addition, temporal correlation coefficients of the DMN 
      were found to be significantly negatively correlated with the HAMD suicidality 
      item scores in MDD patients. These results suggest that MDD may be characterized 
      by excessive temporal fluctuations of dFCs within the DMN and subcortical 
      network, and that decreased stability of DMN connectivity may be particularly 
      associated with the suicidality in MDD.
FAU - Ouyang, Xuan
AU  - Ouyang X
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      The Second Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Long, Yicheng
AU  - Long Y
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      The Second Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Wu, Zhipeng
AU  - Wu Z
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      The Second Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Liu, Dayi
AU  - Liu D
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      The Second Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Liu, Zhening
AU  - Liu Z
AD  - Department of Psychiatry, National Clinical Research Center for Mental Disorders, 
      The Second Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Huang, Xiaojun
AU  - Huang X
AD  - Department of Psychiatry, Jiangxi Provincial People's Hospital, The First 
      Affiliated Hospital of Nanchang Medical College, Nanchang 330006, China.
LA  - eng
GR  - 2021JJ40851/Natural Science Foundation of Hunan Province, China/
GR  - 2021JJ40835/Natural Science Foundation of Hunan Province, China/
GR  - kq2014238/Changsha Municipal Natural Science Foundation/
GR  - 82071506/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20220917
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC9496878
OTO - NOTNLM
OT  - dynamic brain network
OT  - dynamic functional connectivity
OT  - fMRI
OT  - major depressive disorder
OT  - neuroimaging
OT  - suicide
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/17
CRDT- 2022/09/23 01:03
PHST- 2022/08/22 00:00 [received]
PHST- 2022/09/13 00:00 [revised]
PHST- 2022/09/15 00:00 [accepted]
PHST- 2022/09/23 01:03 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/17 00:00 [pmc-release]
AID - brainsci12091263 [pii]
AID - brainsci-12-01263 [pii]
AID - 10.3390/brainsci12091263 [doi]
PST - epublish
SO  - Brain Sci. 2022 Sep 17;12(9):1263. doi: 10.3390/brainsci12091263.