PMID- 36139398
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20230215
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 18
DP  - 2022 Sep 9
TI  - Remodeling of the Neurovascular Unit Following Cerebral Ischemia and Hemorrhage.
LID - 10.3390/cells11182823 [doi]
LID - 2823
AB  - Formulated as a group effort of the stroke community, the transforming concept of 
      the neurovascular unit (NVU) depicts the structural and functional relationship 
      between brain cells and the vascular structure. Composed of both neural and 
      vascular elements, the NVU forms the blood-brain barrier that regulates cerebral 
      blood flow to meet the oxygen demand of the brain in normal physiology and 
      maintain brain homeostasis. Conversely, the dysregulation and dysfunction of the 
      NVU is an essential pathological feature that underlies neurological disorders 
      spanning from chronic neurodegeneration to acute cerebrovascular events such as 
      ischemic stroke and cerebral hemorrhage, which were the focus of this review. We 
      also discussed how common vascular risk factors of stroke predispose the NVU to 
      pathological changes. We synthesized existing literature and first provided an 
      overview of the basic structure and function of NVU, followed by knowledge of how 
      these components remodel in response to ischemic stroke and brain hemorrhage. A 
      greater understanding of the NVU dysfunction and remodeling will enable the 
      design of targeted therapies and provide a valuable foundation for relevant 
      research in this area.
FAU - Sato, Yoshimichi
AU  - Sato Y
AD  - Department of Neurological Surgery, UCSF, San Francisco, CA 94158, USA.
AD  - Department of Neurological Surgery, SFVAMC, San Francisco, CA 94158, USA.
AD  - Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1-1 
      Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
FAU - Falcone-Juengert, Jaime
AU  - Falcone-Juengert J
AD  - Department of Neurological Surgery, UCSF, San Francisco, CA 94158, USA.
AD  - Department of Neurological Surgery, SFVAMC, San Francisco, CA 94158, USA.
FAU - Tominaga, Teiji
AU  - Tominaga T
AUID- ORCID: 0000-0003-3411-2900
AD  - Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 1-1 
      Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
FAU - Su, Hua
AU  - Su H
AUID- ORCID: 0000-0003-1566-9877
AD  - Department of Anesthesia, UCSF, San Francisco, CA 94143, USA.
AD  - Center for Cerebrovascular Research, UCSF, San Francisco, CA 94143, USA.
FAU - Liu, Jialing
AU  - Liu J
AD  - Department of Neurological Surgery, UCSF, San Francisco, CA 94158, USA.
AD  - Department of Neurological Surgery, SFVAMC, San Francisco, CA 94158, USA.
LA  - eng
GR  - R01 NS027713/NS/NINDS NIH HHS/United States
GR  - R01 NS102886/NS/NINDS NIH HHS/United States
GR  - R21 NS120193/NS/NINDS NIH HHS/United States
GR  - IK6 BX004600/BX/BLRD VA/United States
GR  - I01 BX003335/BX/BLRD VA/United States
GR  - R01 NS112819/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20220909
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Brain Ischemia/pathology
MH  - Cerebral Hemorrhage
MH  - Humans
MH  - *Ischemic Stroke
MH  - Oxygen
MH  - *Stroke/pathology
PMC - PMC9496956
OTO - NOTNLM
OT  - NVU
OT  - angiogenesis
OT  - arteriogenesis
OT  - blood-brain barrier
OT  - pericyte
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/09/09
CRDT- 2022/09/23 01:06
PHST- 2022/06/24 00:00 [received]
PHST- 2022/08/18 00:00 [revised]
PHST- 2022/08/30 00:00 [accepted]
PHST- 2022/09/23 01:06 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/09/09 00:00 [pmc-release]
AID - cells11182823 [pii]
AID - cells-11-02823 [pii]
AID - 10.3390/cells11182823 [doi]
PST - epublish
SO  - Cells. 2022 Sep 9;11(18):2823. doi: 10.3390/cells11182823.