PMID- 36139628 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220928 IS - 2072-6694 (Print) IS - 2072-6694 (Electronic) IS - 2072-6694 (Linking) VI - 14 IP - 18 DP - 2022 Sep 15 TI - Utility of the Diffusion Weighted Sequence in Gynecological Imaging: Review Article. LID - 10.3390/cancers14184468 [doi] LID - 4468 AB - Functional imaging with diffusion-weighted imaging (DWI) is a complementary tool to conventional diagnostic magnetic resonance imaging sequences. It is being increasingly investigated to predict tumor response and assess tumor recurrence. We elucidate the specific technical modifications of DWI preferred for gynecological imaging, including the different b-values and planes for image acquisition. Additionally, we discuss the problems and potential pitfalls encountered during DWI interpretation and ways to overcome them. DWI has a wide range of clinical applications in malignant and non-malignant gynecological conditions. It provides supplemental information helpful in diagnosing and managing tubo-ovarian abscess, uterine fibroids, endometriosis, adnexal torsion, and dermoid. Similarly, DWI has diverse applications in gynecological oncology in diagnosis, staging, detection of recurrent disease, and tumor response assessment. Quantitative evaluation with apparent diffusion coefficient (ADC) measurement is being increasingly evaluated for correlation with various tumor parameters in managing gynecological malignancies aiding in preoperative treatment planning. Newer advanced DWI techniques of diffusion tensor imaging (DTI) and whole body DWI with background suppression (DWIBS) and their potential uses in pelvic nerve mapping, preoperative planning, and fertility-preserving surgeries are briefly discussed. FAU - Bonde, Apurva AU - Bonde A AD - Department of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. FAU - Andreazza Dal Lago, Eduardo AU - Andreazza Dal Lago E AD - Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. FAU - Foster, Bryan AU - Foster B AD - Department of Radiology, Oregon Health & Science University, Portland, OR 97239, USA. FAU - Javadi, Sanaz AU - Javadi S AD - Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. FAU - Palmquist, Sarah AU - Palmquist S AD - Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. FAU - Bhosale, Priya AU - Bhosale P AD - Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. LA - eng PT - Journal Article PT - Review DEP - 20220915 PL - Switzerland TA - Cancers (Basel) JT - Cancers JID - 101526829 PMC - PMC9496793 OTO - NOTNLM OT - diffusion weighted imaging OT - gynecological cancers OT - imaging COIS- The authors declare no conflict of interest. EDAT- 2022/09/24 06:00 MHDA- 2022/09/24 06:01 PMCR- 2022/09/15 CRDT- 2022/09/23 01:07 PHST- 2022/07/28 00:00 [received] PHST- 2022/08/30 00:00 [revised] PHST- 2022/09/08 00:00 [accepted] PHST- 2022/09/23 01:07 [entrez] PHST- 2022/09/24 06:00 [pubmed] PHST- 2022/09/24 06:01 [medline] PHST- 2022/09/15 00:00 [pmc-release] AID - cancers14184468 [pii] AID - cancers-14-04468 [pii] AID - 10.3390/cancers14184468 [doi] PST - epublish SO - Cancers (Basel). 2022 Sep 15;14(18):4468. doi: 10.3390/cancers14184468.