PMID- 36139839
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 9
DP  - 2022 Sep 7
TI  - The Activation of Nrf2/HO-1 by 8-Epi-7-deoxyloganic Acid Attenuates Inflammatory 
      Symptoms through the Suppression of the MAPK/NF-kappaB Signaling Cascade in In Vitro 
      and In Vivo Models.
LID - 10.3390/antiox11091765 [doi]
LID - 1765
AB  - In this study, we examined the ameliorative effects of 8-epi-7-deoxyloganic acid 
      (DLA), an iridoid glycoside, on oxidative stress and inflammation in both 
      LPS-stimulated macrophages and mice with carrageenan-induced inflammation. DLA 
      decreased oxidative stress through the up-regulation of heme oxygenase-1 (HO-1) 
      via the activation of nuclear factor erythroid 2-related factor 2 (Nrf2), leading 
      to the suppression of reactive oxygen species (ROS) and nitric oxide generation 
      (NO). In addition, DLA inhibited the activation of mitogen-activated protein 
      kinases (MAPKs) and the nuclear factor kappa-light-chain-enhancer of activated B 
      cells (NF-kappaB) pathway, resulting in a decreased production of the proinflammatory 
      cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) and -6 
      (IL-6), as well as of monocyte chemoattractant protein-1 (MCP-1). In addition, 
      DLA effectively inhibited the generation of nitric oxide (NO) and prostaglandin 
      E2 (PGE2) by inhibiting the expression of the upstream genes inducible nitric 
      oxidase (iNOS) and cyclooxygenase-2 (COX-2). DLA demonstrated powerful 
      anti-inflammatory and antioxidant properties and thus appears as an intriguing 
      prospective therapeutic treatment.
FAU - Simu, Shakina Yesmin
AU  - Simu SY
AD  - College of Pharmacy, Gachon University, No. 191, Hambakmoero, Incheon 21936, 
      Korea.
FAU - Alam, Md Badrul
AU  - Alam MB
AUID- ORCID: 0000-0002-8509-6827
AD  - Department of Food Science and Biotechnology, Graduate School, Kyungpook National 
      University, Daegu 41566, Korea.
AD  - Food and Bio-Industry Research Institute, Inner Beauty/Antiaging Center, 
      Kyungpook National University, Daegu 41566, Korea.
FAU - Kim, Sun Yeou
AU  - Kim SY
AUID- ORCID: 0000-0001-8044-5613
AD  - College of Pharmacy, Gachon University, No. 191, Hambakmoero, Incheon 21936, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20220907
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC9495988
OTO - NOTNLM
OT  - 8-epi-7-deoxyloganic acid
OT  - HO-1
OT  - MAPKs
OT  - NF-kappaB
OT  - Nrf-2
OT  - anti-inflammation
OT  - antioxidant
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/07
CRDT- 2022/09/23 01:08
PHST- 2022/08/08 00:00 [received]
PHST- 2022/09/01 00:00 [revised]
PHST- 2022/09/04 00:00 [accepted]
PHST- 2022/09/23 01:08 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/07 00:00 [pmc-release]
AID - antiox11091765 [pii]
AID - antioxidants-11-01765 [pii]
AID - 10.3390/antiox11091765 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Sep 7;11(9):1765. doi: 10.3390/antiox11091765.