PMID- 36140045
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2079-6382 (Print)
IS  - 2079-6382 (Electronic)
IS  - 2079-6382 (Linking)
VI  - 11
IP  - 9
DP  - 2022 Sep 18
TI  - Effects of One-Stage Full-Mouth Scaling and Root Planing with Azithromycin on 
      Diabetes and Periodontal Disease: A Randomized Controlled Trial.
LID - 10.3390/antibiotics11091266 [doi]
LID - 1266
AB  - Recent reports show that hemoglobin A1c (HbA1c) can be lowered by improving 
      chronic inflammation in periodontal patients with diabetes mellitus and that 
      full-mouth scaling and root planing (FM-SRP), in combination with azithromycin 
      (AZM) treatment, can reduce early periodontal inflammation. However, the 
      association of FM-SRP and AZM with periodontitis and HbA1c in patients with 
      diabetes is largely unknown. This study investigated periodontitis and HbA1c in 
      patients with diabetes after receiving FM-SRP and AZM to evaluate which clinical 
      parameters most reflect the diabetic condition. Fifty-one periodontal patients 
      with diabetes mellitus were included in this study. In total, 25 patients were 
      assigned to the FM-SRP group in which patients were treated with FM-SRP in 
      combination with AZM, and 26 patients were assigned to the control group in which 
      only supragingival calculus removal was performed along with the provision of 
      oral hygiene instructions. We evaluated periodontal parameters (probing pocket 
      depth, periodontal inflamed surface area (PISA), bleeding on probing), and 
      periodontal bacteria and biochemical parameters (HbA1c, high-sensitive C-reactive 
      protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and 
      monocyte chemoattractant protein-1 (MCP-1)) at baseline (BL) and 1, 3, 6, and 9 
      months after treatment. Compared with BL values, the FM-SRP group showed improved 
      clinical parameters, reduced periodontal pathogens, and significantly lower 
      HbA1c. Inflammatory cytokines (hs-CRP, TNF-alpha, IL-6) were significantly reduced 
      one month after treatment and remained low thereafter. MCP-1 did not change 
      significantly during the experimental period. PISA showed a strong correlation 
      with HbA1c, hs-CRP, and TNF-alpha. FM-SRP, in combination with AZM, produced 
      clinical, microbiological, and HbA1c improvements in periodontal patients with 
      previously diagnosed diabetes mellitus. Additionally, PISA was shown to be a 
      useful index for assessing the diabetic status of patients with periodontal 
      disease.
FAU - Komatsu, Sho
AU  - Komatsu S
AD  - Department of Periodontology, Tsurumi University School of Dental Medicine, 2-1-3 
      Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan.
FAU - Oshikiri, Shotaro
AU  - Oshikiri S
AD  - Department of Periodontology, Tsurumi University School of Dental Medicine, 2-1-3 
      Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan.
FAU - Nagano, Takatoshi
AU  - Nagano T
AD  - Department of Periodontology, Tsurumi University School of Dental Medicine, 2-1-3 
      Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan.
FAU - Yashima, Akihiro
AU  - Yashima A
AD  - Department of Periodontology, Tsurumi University School of Dental Medicine, 2-1-3 
      Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan.
FAU - Matsushima, Yuji
AU  - Matsushima Y
AUID- ORCID: 0000-0003-1784-6101
AD  - Department of Periodontology, Tsurumi University School of Dental Medicine, 2-1-3 
      Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan.
FAU - Shirakawa, Satoshi
AU  - Shirakawa S
AUID- ORCID: 0000-0001-7266-6037
AD  - Department of Dental Hygiene, Tsurumi Junior College, 2-1-3 Tsurumi, Tsurumi ku, 
      Yokohama 230-8501, Japan.
FAU - Komatsu, Katsutoshi
AU  - Komatsu K
AD  - Komatsu Clinic, 1989-66 Denbo, Fuji 417-0061, Japan.
FAU - Mokubo, Akiko
AU  - Mokubo A
AD  - Mokubo Internal Medicine Clinic, 2-25 Kizukimotosumicho, Kawasaki 211-0021, 
      Japan.
FAU - Gomi, Kazuhiro
AU  - Gomi K
AUID- ORCID: 0000-0003-4484-6238
AD  - Department of Periodontology, Tsurumi University School of Dental Medicine, 2-1-3 
      Tsurumi, Tsurumi ku, Yokohama 230-8501, Japan.
LA  - eng
GR  - 18K09589/Japan Society for the Promotion of Science/
PT  - Journal Article
DEP - 20220918
PL  - Switzerland
TA  - Antibiotics (Basel)
JT  - Antibiotics (Basel, Switzerland)
JID - 101637404
PMC - PMC9495786
OTO - NOTNLM
OT  - diabetes
OT  - full-mouth scaling and root planning
OT  - inflammatory cytokines
OT  - periodontal disease
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/18
CRDT- 2022/09/23 01:09
PHST- 2022/08/25 00:00 [received]
PHST- 2022/08/31 00:00 [revised]
PHST- 2022/09/15 00:00 [accepted]
PHST- 2022/09/23 01:09 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/18 00:00 [pmc-release]
AID - antibiotics11091266 [pii]
AID - antibiotics-11-01266 [pii]
AID - 10.3390/antibiotics11091266 [doi]
PST - epublish
SO  - Antibiotics (Basel). 2022 Sep 18;11(9):1266. doi: 10.3390/antibiotics11091266.