PMID- 36142912
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 18
DP  - 2022 Sep 6
TI  - Relationship of Neuropeptide S (NPS) with Neurocognitive, Clinical, and 
      Electrophysiological Parameters of Patients during Structured Rehabilitation 
      Therapy for Schizophrenia.
LID - 10.3390/jcm11185266 [doi]
LID - 5266
AB  - INTRODUCTION: Neuropeptide S is a biomarker related to various neuropsychiatric 
      and neurocognitive functions. Since the need to improve cognitive functions in 
      schizophrenia is unquestionable, it was valuable to investigate the possible 
      relationships of plasma levels of NPS with neurocognitive, psychopathological and 
      EEG parameters in patients with schizophrenia. AIM: Relationships between the 
      serum NPS level and neurocognitive, clinical, and electrophysiological parameters 
      were investigated in patients diagnosed with schizophrenia who underwent 
      structured rehabilitation therapy. METHODS: Thirty-three men diagnosed with 
      schizophrenia were randomized into two groups. The REH group (N16) consisted of 
      patients who underwent structured rehabilitation therapy, the CON group (N17) 
      continued its previous treatment. Additionally, the reference NPS serum results 
      were checked in a group of healthy people (N15). In the study several tests 
      assessing various neurocognitive functions were used: d2 Sustained-Attention Test 
      (d2), Color Trails Test (CTT), Beck Cognitive Insight Scale (BCIS), Acceptance of 
      Illness Scale (AIS), and General Self-Efficacy Scale (GSES). The clinical 
      parameters were measured with Positive and Negative Syndrome Scale (PANSS) and 
      electrophysiological parameters were analyzed with auditory evoked potentials 
      (AEPs) and quantitative electroencephalography (QEEG). The NPS, neurocognitive, 
      clinical, and electrophysiological results of REH and CON groups were recorded at 
      the beginning (T1) and after a period of 3 months (T2). RESULTS: A decreased 
      level of NPS was associated with the improvement in specific complex indices of 
      d2 and BCIS neurocognitive tests, as well as the improvement in the clinical 
      state (PANSS). No correlation was observed between the level of NPS and the 
      results of AEPs and QEEG measurements. CONCLUSIONS: A decreased level of NPS is 
      possibly related to the improvement in metacognition and social cognition 
      domains, as well as to clinical improvement during the rehabilitation therapy of 
      patients with schizophrenia.
FAU - Markiewicz-Gospodarek, Agnieszka
AU  - Markiewicz-Gospodarek A
AUID- ORCID: 0000-0002-6266-0261
AD  - Department of Human Anatomy, Medical University of Lublin, 20-090 Lublin, Poland.
FAU - Markiewicz, Renata
AU  - Markiewicz R
AD  - Department of Neurology, Neurological and Psychiatric Nursing, Medical University 
      of Lublin, 20-093 Lublin, Poland.
FAU - Dobrowolska, Beata
AU  - Dobrowolska B
AUID- ORCID: 0000-0001-9178-9534
AD  - Department of Holistic Care and Management in Nursing, Medical University of 
      Lublin, 20-081 Lublin, Poland.
FAU - Rahnama, Mansur
AU  - Rahnama M
AD  - Department of Oral Surgery, Medical University of Lublin, 20-093 Lublin, Poland.
FAU - Loza, Bartosz
AU  - Loza B
AD  - Department of Psychiatry, Medical University of Warsaw, 02-091 Warsaw, Poland.
LA  - eng
PT  - Journal Article
DEP - 20220906
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9506378
OTO - NOTNLM
OT  - AEP
OT  - QEEG
OT  - cognitive functioning
OT  - neuropeptide S
OT  - rehabilitation
OT  - schizophrenia
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/06
CRDT- 2022/09/23 01:27
PHST- 2022/07/15 00:00 [received]
PHST- 2022/08/29 00:00 [revised]
PHST- 2022/09/03 00:00 [accepted]
PHST- 2022/09/23 01:27 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/06 00:00 [pmc-release]
AID - jcm11185266 [pii]
AID - jcm-11-05266 [pii]
AID - 10.3390/jcm11185266 [doi]
PST - epublish
SO  - J Clin Med. 2022 Sep 6;11(18):5266. doi: 10.3390/jcm11185266.