PMID- 36143021
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 18
DP  - 2022 Sep 13
TI  - Right Heart Catheterization in Pediatric Pulmonary Arterial Hypertension: 
      Insights and Outcome from a Large Tertiary Center.
LID - 10.3390/jcm11185374 [doi]
LID - 5374
AB  - Aim: To define the clinical characteristics, hemodynamics, and adverse events for 
      pediatric patients with pulmonary arterial hypertension (PAH) undergoing right 
      heart catheterization (RHC). Methods: The large referral single center data of 
      591 diagnostic RHC procedures performed between 2005 and 2020 on pediatric PAH 
      patients was retrospectively collected and analyzed. Results: A total of 591 RHC 
      procedures performed on 469 patients with congenital heart disease (CHD)-PAH 
      (median age 8.8 years, 7.9% New York Heart Association (NYHA) class > II, 1.5% 
      with syncope) and 122 patients with idiopathic PAH (median age of 9.0 years, 
      27.0% NYHA class > II, 27.0% with syncope) were included. Of those, 373 (63.1%) 
      procedures were performed under general anesthesia. Eighteen patients (18/591, 
      3.0%) suffered adverse events (mainly pulmonary hypertensive crisis, PHC, n = 17) 
      during the RHC procedure, including 14 idiopathic pulmonary arterial hypertension 
      (IPAH) patients and 4 CHD-PAH patients, and one IPAH patient died in hospital 63 
      hours after RHC. The risk of developing PHC was significantly increased in 
      patients with IPAH (OR = 14.02, 95%CI: 4.49-43.85, p < 0.001), atrial blood gas 
      pH < 7.35 (OR = 12.504, 95%CI: 3.545-44.102, p < 0.001) and RAP > 14 mmHg (OR = 
      10.636, 95%CI: 3.668-30.847, p < 0.001). Conclusions: RHC is generally a low-risk 
      procedure in pediatric patients with PAH. However, PHC occur in approximately 3% 
      of patients. Therefore, RHC should be performed in a large, experienced referral 
      pediatric cardiology center, especially in pediatric patients with IPAH requiring 
      general anesthesia.
FAU - Xu, Zhuoyuan
AU  - Xu Z
AD  - Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
AD  - Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
FAU - Zhang, Hongsheng
AU  - Zhang H
AD  - Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
AD  - Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
FAU - Arvanitaki, Alexandra
AU  - Arvanitaki A
AUID- ORCID: 0000-0003-3180-7280
AD  - 1st Department of Cardiology, AHEPA University Hospital, 54621 Thessaloniki, 
      Greece.
AD  - Pulmonary Hypertension Service, Royal Brompton Hospital, London SW3 6NP, UK.
FAU - Zhang, Chen
AU  - Zhang C
AD  - Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
AD  - Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
FAU - Li, Qiangqiang
AU  - Li Q
AD  - Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
AD  - Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
FAU - Keller, Bradley B
AU  - Keller BB
AUID- ORCID: 0000-0001-5476-6050
AD  - Greater Louisville and Western Kentucky Practice, Cincinnati Children's Heart 
      Institute, Louisville, KY 40202, USA.
FAU - Gu, Hong
AU  - Gu H
AD  - Department of Pediatric Cardiology, Beijing Anzhen Hospital, Capital Medical 
      University, Beijing 100029, China.
AD  - Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
LA  - eng
PT  - Journal Article
DEP - 20220913
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9500744
OTO - NOTNLM
OT  - outcome
OT  - pediatric
OT  - pulmonary arterial hypertension
OT  - right heart catheterization
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/13
CRDT- 2022/09/23 01:27
PHST- 2022/08/16 00:00 [received]
PHST- 2022/08/30 00:00 [revised]
PHST- 2022/09/02 00:00 [accepted]
PHST- 2022/09/23 01:27 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/13 00:00 [pmc-release]
AID - jcm11185374 [pii]
AID - jcm-11-05374 [pii]
AID - 10.3390/jcm11185374 [doi]
PST - epublish
SO  - J Clin Med. 2022 Sep 13;11(18):5374. doi: 10.3390/jcm11185374.