PMID- 36143268
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 9
DP  - 2022 Sep 10
TI  - Association of Inflammatory and Metabolic Biomarkers with Mitral Annular 
      Calcification in Type 2 Diabetes Patients.
LID - 10.3390/jpm12091484 [doi]
LID - 1484
AB  - (1) Background: Type 2 diabetes mellitus (T2DM) contributes to cardiovascular 
      disease and related mortality through the insidious effects of insulin resistance 
      and chronic inflammation. Mitral annular calcification (MAC) is one such 
      degenerative process promoted by T2DM. (2) Methods: This is a post hoc analysis 
      of insulin resistance, inflammation, and hepatic steatosis markers in T2DM 
      patients without atherosclerotic manifestations, but with incidental 
      echocardiographic detection of mild MAC. (3) Results: 138 consenting patients 
      were 49.3% men, 57.86 years old, with a history of T2DM of 6.16 years and HbA(1c) 
      8.06%, of whom sixty had mild MAC (43.47%). The statistically significant 
      differences between patients with/without MAC were higher HOMA C-peptide and 
      C-peptide index for insulin resistance, higher TNF-alpha for inflammation, and lower 
      estimated glomerular filtration rate. High-sensitive C-reactive protein (hsCRP) 
      was significantly associated with insulin resistance and the strength of the 
      relationship was higher in the MAC group. Predictive of MAC were TNF-alpha, HOMA 
      C-peptide, and especially hepatic steatosis and hypertension. (4) Conclusions: 
      MAC was more prevalent than reported in the literature. Insulin resistance and 
      inflammation were predictive of MAC, but significant markers differ across 
      studies. Widely available routine tests and echocardiographic assessments are 
      useful in the early identification of mitral annular calcifications in diabetes 
      patients.
FAU - Grigorescu, Elena-Daniela
AU  - Grigorescu ED
AUID- ORCID: 0000-0002-7721-554X
AD  - Unit of Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University 
      of Medicine and Pharmacy, 700115 Iasi, Romania.
FAU - Lacatusu, Cristina-Mihaela
AU  - Lacatusu CM
AUID- ORCID: 0000-0002-9012-5901
AD  - Unit of Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University 
      of Medicine and Pharmacy, 700115 Iasi, Romania.
AD  - Clinical Center of Diabetes, Nutrition and Metabolic Diseases, "St. Spiridon" 
      County Clinical Emergency Hospital, 700111 Iasi, Romania.
FAU - Floria, Mariana
AU  - Floria M
AUID- ORCID: 0000-0002-9465-1503
AD  - Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 
      Iasi, Romania.
AD  - Department of Internal Medicine, "St. Spiridon" County Clinical Emergency 
      Hospital, 700111 Iasi, Romania.
FAU - Cazac, Georgiana-Diana
AU  - Cazac GD
AUID- ORCID: 0000-0002-6993-5491
AD  - Unit of Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University 
      of Medicine and Pharmacy, 700115 Iasi, Romania.
AD  - Clinical Center of Diabetes, Nutrition and Metabolic Diseases, "St. Spiridon" 
      County Clinical Emergency Hospital, 700111 Iasi, Romania.
FAU - Onofriescu, Alina
AU  - Onofriescu A
AD  - Unit of Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University 
      of Medicine and Pharmacy, 700115 Iasi, Romania.
AD  - Clinical Center of Diabetes, Nutrition and Metabolic Diseases, "St. Spiridon" 
      County Clinical Emergency Hospital, 700111 Iasi, Romania.
FAU - Ceasovschih, Alexandr
AU  - Ceasovschih A
AUID- ORCID: 0000-0002-0043-9051
AD  - Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 
      Iasi, Romania.
AD  - Department of Internal Medicine, "St. Spiridon" County Clinical Emergency 
      Hospital, 700111 Iasi, Romania.
FAU - Cretu, Ioana
AU  - Cretu I
AD  - Cretu R. Ioana PFA, 707020 Aroneanu, Romania.
FAU - Mihai, Bogdan-Mircea
AU  - Mihai BM
AUID- ORCID: 0000-0003-0413-026X
AD  - Unit of Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University 
      of Medicine and Pharmacy, 700115 Iasi, Romania.
AD  - Clinical Center of Diabetes, Nutrition and Metabolic Diseases, "St. Spiridon" 
      County Clinical Emergency Hospital, 700111 Iasi, Romania.
FAU - Sorodoc, Laurentiu
AU  - Sorodoc L
AD  - Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 
      Iasi, Romania.
AD  - Department of Internal Medicine, "St. Spiridon" County Clinical Emergency 
      Hospital, 700111 Iasi, Romania.
LA  - eng
PT  - Journal Article
DEP - 20220910
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9502175
OTO - NOTNLM
OT  - C-peptide
OT  - HOMA-IR
OT  - TNF-alpha
OT  - hsCRP
OT  - mitral annular calcification
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/10
CRDT- 2022/09/23 01:29
PHST- 2022/08/05 00:00 [received]
PHST- 2022/08/28 00:00 [revised]
PHST- 2022/09/07 00:00 [accepted]
PHST- 2022/09/23 01:29 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/10 00:00 [pmc-release]
AID - jpm12091484 [pii]
AID - jpm-12-01484 [pii]
AID - 10.3390/jpm12091484 [doi]
PST - epublish
SO  - J Pers Med. 2022 Sep 10;12(9):1484. doi: 10.3390/jpm12091484.