PMID- 36143422
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 12
IP  - 9
DP  - 2022 Sep 6
TI  - Mdivi-1 Induced Mitochondrial Fusion as a Potential Mechanism to Enhance Stress 
      Tolerance in Wheat.
LID - 10.3390/life12091386 [doi]
LID - 1386
AB  - Mitochondria play a key role in providing energy to cells. These organelles are 
      constantly undergoing dynamic processes of fusion and fission that change in 
      stressful conditions. The role of mitochondrial fusion in wheat root cells was 
      studied using Mdivi-1, an inhibitor of the mitochondrial fragmentation protein 
      Drp1. The effect of the inhibitor was studied on mitochondrial dynamics in the 
      roots of wheat seedlings subjected to a wounding stress, simulated by excision. 
      Treatment of the stressed roots with the inhibitor increased the size of the 
      mitochondria, enhanced their functional activity, and elevated their membrane 
      potentials. Mitochondrial fusion was accompanied by a decrease in ROS formation 
      and associated cell damage. Exposure to Mdivi-1 also upregulated genes encoding 
      the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and an 
      energy sensor AMP-dependent protein sucrose non-fermenting-related kinase 
      (SnRK1), suggesting that mitochondrial fusion is associated with a general 
      activation of energy metabolism. Controlling mitochondrial fusion rates could 
      change the physiology of wheat plants by altering the energy status of the cell 
      and helping to mitigate the effects of stress.
FAU - Rakhmatullina, Daniya
AU  - Rakhmatullina D
AD  - Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, 
      Russian Academy of Sciences, 420111 Kazan, Russia.
FAU - Mazina, Anastasia
AU  - Mazina A
AD  - Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, 
      Russian Academy of Sciences, 420111 Kazan, Russia.
FAU - Ponomareva, Anastasia
AU  - Ponomareva A
AUID- ORCID: 0000-0003-2038-0445
AD  - Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, 
      Russian Academy of Sciences, 420111 Kazan, Russia.
FAU - Dmitrieva, Svetlana
AU  - Dmitrieva S
AD  - Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, 
      Russian Academy of Sciences, 420111 Kazan, Russia.
FAU - Beckett, Richard Peter
AU  - Beckett RP
AUID- ORCID: 0000-0002-0530-4244
AD  - School of Life Sciences, University of KwaZulu-Natal, Scottsville 3209, South 
      Africa.
FAU - Minibayeva, Farida
AU  - Minibayeva F
AUID- ORCID: 0000-0003-0827-181X
AD  - Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center, 
      Russian Academy of Sciences, 420111 Kazan, Russia.
AD  - Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal 
      University, 420008 Kazan, Russia.
LA  - eng
GR  - 0217-2019-0006/FRC KazSC RAS/
PT  - Journal Article
DEP - 20220906
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC9503966
OTO - NOTNLM
OT  - energy status
OT  - fusion
OT  - mitochondria
OT  - redox metabolism
OT  - wheat
OT  - wounding
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/06
CRDT- 2022/09/23 01:30
PHST- 2022/08/24 00:00 [received]
PHST- 2022/09/02 00:00 [revised]
PHST- 2022/09/05 00:00 [accepted]
PHST- 2022/09/23 01:30 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/06 00:00 [pmc-release]
AID - life12091386 [pii]
AID - life-12-01386 [pii]
AID - 10.3390/life12091386 [doi]
PST - epublish
SO  - Life (Basel). 2022 Sep 6;12(9):1386. doi: 10.3390/life12091386.