PMID- 36143943
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20230308
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 9
DP  - 2022 Sep 13
TI  - Association of Blood MCP-1 Levels with Risk of Obstructive Sleep Apnea: A 
      Systematic Review and Meta-Analysis.
LID - 10.3390/medicina58091266 [doi]
LID - 1266
AB  - Background and objective: Among the broad variety of chemokines, monocyte 
      chemoattractant protein-1 (MCP-1) is considered to be one of the most important 
      chemokines. Among others, MCP-1 activates monocytes and other immune cells highly 
      involved in inflammation. In the present systematic review and meta-analysis, we 
      evaluated the relationship between serum/plasma MCP-1 levels and the risk of 
      obstructive sleep apnea (OSA) in adults as a disease related to inflammation. 
      Materials and methods: Four databases were systematically investigated until 12 
      July 2022. We used the Review Manager 5.3 software (Copenhagen: The Nordic 
      Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark) to extract and 
      calculate the standardized mean difference (SMD) and its 95% confidence interval 
      (CI) of plasma/serum levels of MCP-1 between adults with and without OSA. 
      Results: Eight articles including eleven studies in adults were entered into the 
      meta-analysis. The serum/plasma MCP-1 levels in adults with OSA were higher than 
      that in the controls (SMD = 0.81; p = 0.0007) and as well as for adults with 
      severe OSA compared to those with mild and moderate OSA (SMD = 0.42; p < 0.0001). 
      The subgroup analysis showed that ethnicity was an effective factor in the pooled 
      analysis of blood MCP-1 levels in adults with OSA compared to the controls 
      (Asians: (p < 0.0001), mixed ethnicity: (p = 0.04), and Caucasians: (p = 0.89)). 
      The meta-regression showed increasing serum/plasma MCP-1 levels in adults with 
      OSA versus the controls, publication year, age of controls, body mass index (BMI) 
      of controls, and sample size reduced, and also BMI and the apnea-hypopnea index 
      of adults with OSA increased. Conclusions: The meta-analysis showed that compared 
      to the controls, serum/plasma levels of MCP-1 in adults with OSA were 
      significantly more, as well as adults with severe OSA having more serum/plasma 
      MCP-1 levels compared to the adults with mild to moderate OSA. Therefore, MCP-1 
      can be used as a diagnostic and therapeutic factor in adults with OSA.
FAU - Imani, Mohammad Moslem
AU  - Imani MM
AD  - Department of Orthodontics, Kermanshah University of Medical Sciences, Kermanshah 
      6715847141, Iran.
FAU - Sadeghi, Masoud
AU  - Sadeghi M
AD  - Department of Biology, Science and Research Branch, Islamic Azad University, 
      Tehran 1477893855, Iran.
FAU - Mohammadi, Mehdi
AU  - Mohammadi M
AD  - Students Research Committee, Kermanshah University of Medical Sciences, 
      Kermanshah 6715847141, Iran.
FAU - Bruhl, Annette Beatrix
AU  - Bruhl AB
AUID- ORCID: 0000-0003-4704-4986
AD  - Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University 
      Hospital Basel, 4002 Basel, Switzerland.
FAU - Sadeghi-Bahmani, Dena
AU  - Sadeghi-Bahmani D
AUID- ORCID: 0000-0002-1301-5522
AD  - Department of Psychology, Stanford University, Stanford, CA 94305, USA.
AD  - Sleep Disorders Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah 6715847141, Iran.
FAU - Brand, Serge
AU  - Brand S
AUID- ORCID: 0000-0003-2175-2765
AD  - Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University 
      Hospital Basel, 4002 Basel, Switzerland.
AD  - Sleep Disorders Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah 6715847141, Iran.
AD  - Substance Abuse Prevention Research Center, Kermanshah University of Medical 
      Sciences, Kermanshah 6719851115, Iran.
AD  - Department of Sport, Exercise and Health, Division of Sport Science and 
      Psychosocial Health, University of Basel, 4052 Basel, Switzerland.
AD  - School of Medicine, Tehran University of Medical Sciences, Tehran 1417466191, 
      Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20220913
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - *Chemokine CCL2
MH  - Humans
MH  - Inflammation
MH  - Monocytes
MH  - *Sleep Apnea, Obstructive
PMC - PMC9506345
OTO - NOTNLM
OT  - blood
OT  - cytokine
OT  - meta-analysis
OT  - monocyte chemoattractant protein-1
OT  - obstructive sleep apnea
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/09/13
CRDT- 2022/09/23 01:33
PHST- 2022/08/06 00:00 [received]
PHST- 2022/08/29 00:00 [revised]
PHST- 2022/09/09 00:00 [accepted]
PHST- 2022/09/23 01:33 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/09/13 00:00 [pmc-release]
AID - medicina58091266 [pii]
AID - medicina-58-01266 [pii]
AID - 10.3390/medicina58091266 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Sep 13;58(9):1266. doi: 10.3390/medicina58091266.