PMID- 36145115
OWN - NLM
STAT- MEDLINE
DCOM- 20220926
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 18
DP  - 2022 Sep 10
TI  - Acute Flaxseed Intake Reduces Postprandial Glycemia in Subjects with Type 2 
      Diabetes: A Randomized Crossover Clinical Trial.
LID - 10.3390/nu14183736 [doi]
LID - 3736
AB  - Background: Postprandial glycemic excursions are associated with impairment 
      control of diabetes mellitus. Long-term consumption of flaxseed can lower blood 
      glucose levels; however, its effects on the postprandial glycemic response remain 
      unknown. Therefore, this study aimed to evaluate the acute effects of raw 
      flaxseed consumption on the 2 h postprandial glycemic curve in men with type 2 
      diabetes mellitus (T2DM). Methods: This was a randomized crossover clinical 
      trial. Nineteen men with T2DM were randomly assigned a standardized breakfast 
      without (control) or with a previous intake of 15 g of ground raw golden flaxseed 
      (flax). Glycemia was measured at fasting and postprandial at 15, 30, 45, 60, 90, 
      and 120 min. Palatability markers (visual appeal, smell, and pleasantness of 
      taste) and taste intensity (sweetness, saltiness, bitterness, sourness, and 
      creaminess) were evaluated. Results: The peak glucose rise and the 2 h AUC 
      glycemic response reduced in the flax group by 17% (p = 0.001) and 24% (p < 
      0.001), respectively. The glucose peak time, palatability, and taste parameters 
      did not differ between the two groups. Conclusions: Ingestion of 15 g of ground 
      raw golden flaxseed before breakfast decreases the 2 h postprandial glycemic 
      response in men with T2DM.
FAU - Moreira, Fernanda Duarte
AU  - Moreira FD
AD  - Coordenacao Geral de Atencao as Pessoas com Doencas Cronicas, Ministerio da 
      Saude, Brasilia 70058-900, Brazil.
AD  - Programa de Pos-Graduacao em Ciencias e Tecnologias em Saude, Universidade de 
      Brasilia, Brasilia 72220-275, Brazil.
FAU - Reis, Caio Eduardo Goncalves
AU  - Reis CEG
AUID- ORCID: 0000-0001-7260-9497
AD  - Departamento de Nutricao, Universidade de Brasilia, Brasilia 70910-900, Brazil.
FAU - Welker, Alexis Fonseca
AU  - Welker AF
AUID- ORCID: 0000-0002-5894-005X
AD  - Programa de Pos-Graduacao em Ciencias e Tecnologias em Saude, Universidade de 
      Brasilia, Brasilia 72220-275, Brazil.
FAU - Gallassi, Andrea Donatti
AU  - Gallassi AD
AUID- ORCID: 0000-0003-1852-485X
AD  - Programa de Pos-Graduacao em Ciencias e Tecnologias em Saude, Universidade de 
      Brasilia, Brasilia 72220-275, Brazil.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220910
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Blood Glucose
MH  - Cross-Over Studies
MH  - *Diabetes Mellitus, Type 2
MH  - *Flax
MH  - Glucose
MH  - Glycemic Index
MH  - Humans
MH  - Insulin
MH  - Male
MH  - Postprandial Period
PMC - PMC9503020
OTO - NOTNLM
OT  - complex carbohydrates
OT  - diabetes mellitus
OT  - dietary fiber
OT  - flaxseed
OT  - postprandial blood glucose
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/09/10
CRDT- 2022/09/23 01:39
PHST- 2022/08/19 00:00 [received]
PHST- 2022/09/02 00:00 [revised]
PHST- 2022/09/06 00:00 [accepted]
PHST- 2022/09/23 01:39 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/09/10 00:00 [pmc-release]
AID - nu14183736 [pii]
AID - nutrients-14-03736 [pii]
AID - 10.3390/nu14183736 [doi]
PST - epublish
SO  - Nutrients. 2022 Sep 10;14(18):3736. doi: 10.3390/nu14183736.