PMID- 36145727
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Sep 19
TI  - 3D Bioprinted Chitosan-Based Hydrogel Scaffolds in Tissue Engineering and 
      Localised Drug Delivery.
LID - 10.3390/pharmaceutics14091978 [doi]
LID - 1978
AB  - Bioprinting is an emerging technology with various applications in developing 
      functional tissue constructs for the replacement of harmed or damaged tissues and 
      simultaneously controlled drug delivery systems (DDSs) for the administration of 
      several active substances, such as growth factors, proteins, and drug molecules. 
      It is a novel approach that provides high reproducibility and precise control 
      over the fabricated constructs in an automated way. An ideal bioink should 
      possess proper mechanical, rheological, and biological properties essential to 
      ensure proper function. Chitosan is a promising natural-derived polysaccharide to 
      be used as ink because of its attractive properties, such as biodegradability, 
      biocompatibility, low cost, and non-immunogenicity. This review focuses on 3D 
      bioprinting technology for the preparation of chitosan-based hydrogel scaffolds 
      for the regeneration of tissues delivering either cells or active substances to 
      promote restoration.
FAU - Lazaridou, Maria
AU  - Lazaridou M
AUID- ORCID: 0000-0002-3220-1494
AD  - Laboratory of Chemistry and Technology of Polymers and Dyes, Department of 
      Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
FAU - Bikiaris, Dimitrios N
AU  - Bikiaris DN
AUID- ORCID: 0000-0001-8458-4952
AD  - Laboratory of Chemistry and Technology of Polymers and Dyes, Department of 
      Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
FAU - Lamprou, Dimitrios A
AU  - Lamprou DA
AUID- ORCID: 0000-0002-8740-1661
AD  - School of Pharmacy, Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 
      7BL, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220919
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC9500618
OTO - NOTNLM
OT  - 3D bioprinting
OT  - bioink
OT  - biomaterials
OT  - chitosan
OT  - drug delivery
OT  - tissue engineering
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/19
CRDT- 2022/09/23 01:43
PHST- 2022/08/29 00:00 [received]
PHST- 2022/09/17 00:00 [revised]
PHST- 2022/09/18 00:00 [accepted]
PHST- 2022/09/23 01:43 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/19 00:00 [pmc-release]
AID - pharmaceutics14091978 [pii]
AID - pharmaceutics-14-01978 [pii]
AID - 10.3390/pharmaceutics14091978 [doi]
PST - epublish
SO  - Pharmaceutics. 2022 Sep 19;14(9):1978. doi: 10.3390/pharmaceutics14091978.