PMID- 36147176
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220924
IS  - 2049-0801 (Print)
IS  - 2049-0801 (Electronic)
IS  - 2049-0801 (Linking)
VI  - 81
DP  - 2022 Sep
TI  - Severe hemolysis with negative direct antiglobulin test: A case report.
PG  - 104444
LID - 10.1016/j.amsu.2022.104444 [doi]
LID - 104444
AB  - A 49-year-old woman with type 2 diabetes mellitus (T2DM) presented to the 
      emergency department. Her examination showed marked pallor, exhaustion, lethargy, 
      yellowish eyes, anorexia, nausea and vomiting. Hematuria; negative standard 
      direct antiglobulin test (DAT); normal glucose 6 phosphate dehydrogenase (G6PD); 
      hemoglobin (Hb), 4.8 g/dl; Mean cell volume (MCV), 91fl; platelet count, 
      233 x 10(6)/L; Total bilirubin, 7.0 mg/dl; Glucose, 316 mg/dl; lactate 
      dehydrogenase (LDH), 1750U/L. Undoubtedly, therapeutic panel should have been 
      used for hemolytic anemia. Intravenous (IV) fluids and 2 units of packed cell 
      were transfused. Methylprednisolone with rituximab were started for the patient. 
      After 3 weeks of the patient admission, she was discharged home with stable vital 
      signs and Hb, 10 g/dl. We concluded in the cases that presented along with a 
      severe drop in Hb and evidence of hemolysis which non immune hemolytic anemia is 
      excluded in spite of negative standard DAT limited transfusion besides 
      corticosteroids combined with rituximab, could be helpful in saving the patient.
CI  - (c) 2022 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.
FAU - Behzadifard, Mahin
AU  - Behzadifard M
AD  - Dezful University of Medical Sciences, Dezful, Iran.
FAU - Arianezhad, Ali
AU  - Arianezhad A
AD  - Dezful University of Medical Sciences, Dezful, Iran.
FAU - Bandehzadeh, Ali
AU  - Bandehzadeh A
AD  - Dezful University of Medical Sciences, Dezful, Iran.
FAU - Gholampour, Mohammadali
AU  - Gholampour M
AD  - Department of Medicine, Lung Biology Center, Cardiovascular Research Institute, 
      University of California, San Francisco, CA, USA.
LA  - eng
PT  - Case Reports
DEP - 20220818
PL  - England
TA  - Ann Med Surg (Lond)
JT  - Annals of medicine and surgery (2012)
JID - 101616869
PMC - PMC9486623
OTO - NOTNLM
OT  - Anti-human globulin
OT  - Autoimmune hemolytic anemia
OT  - Coomb's test
OT  - DAT
OT  - Direct antiglobulin test
COIS- The authors declare that they have no competing interests.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/08/18
CRDT- 2022/09/23 02:34
PHST- 2022/06/26 00:00 [received]
PHST- 2022/08/06 00:00 [revised]
PHST- 2022/08/12 00:00 [accepted]
PHST- 2022/09/23 02:34 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/08/18 00:00 [pmc-release]
AID - S2049-0801(22)01204-3 [pii]
AID - 104444 [pii]
AID - 10.1016/j.amsu.2022.104444 [doi]
PST - epublish
SO  - Ann Med Surg (Lond). 2022 Aug 18;81:104444. doi: 10.1016/j.amsu.2022.104444. 
      eCollection 2022 Sep.