PMID- 36147773
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220924
IS  - 1565-3633 (Print)
IS  - 1687-479X (Electronic)
VI  - 2022
DP  - 2022
TI  - Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, 
      Characterization, Cytotoxicity, and Biological Imaging.
PG  - 7821284
LID - 10.1155/2022/7821284 [doi]
LID - 7821284
AB  - Platinum-based compounds are actively used in clinical trials as anticancer 
      agents. In this study, two novel platinum complexes, 
      (C1 = [PtCl(2)(N(SO(2)quin)dpa)], C2 = [PtCl(2)(N(SO(2)azobenz)dpa)]) containing 
      quinoline and azobenzene appended dipicolylamine sulfonamide ligands were 
      synthesized in good yield. The singlet attributable to methylene CH(2) protons of 
      the ligands of C1 and C2 appears as two doublets in (1)H NMR spectra, which 
      confirms the presence of magnetically nonequivalent protons upon coordination to 
      platinum. Structural data of N(SO(2)quin)dpa (L1), N(SO(2)azobenz)dpa (L2) and 
      PtCl(2)(N(SO(2)quin)dpa) confirmed the formation of the desired compounds. 
      Time-dependent density functional theory calculations suggested that the 
      excitation of L1 show quin-unit-based pi⟶pi ( *) excitations (i.e., ligand-centered 
      charge transfer, LC), while C1 shows the metal-ligand-to-ligand charge-transfer 
      (MLLCT) character. L1 displays intense fluorescence from the (1)LC excited state, 
      while C1 gives phosphorescence from the (3)LC state. Mammalian cell toxicity of 
      ligands and complexes was assessed with NCI-H292 nonsmall-cell lung cancer cells. 
      Further, C1 and C2 showed significantly low IC(50) values compared with 
      N(SO(2)azobenz)dpa and PtCl(2)(N(SO(2)quin)dpa). Fluorescence imaging data of 
      both ligands and complexes revealed the potential fluorescence activity of these 
      compounds for biological imaging. All four compounds are promising novel 
      candidates that can be further investigated on their usage as potential 
      anticancer agents and cancer cell imaging agents.
CI  - Copyright (c) 2022 Charini Maladeniya et al.
FAU - Maladeniya, Charini
AU  - Maladeniya C
AUID- ORCID: 0000-0002-0510-1711
AD  - Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
FAU - Darshani, Taniya
AU  - Darshani T
AD  - Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
FAU - Samarakoon, Sameera R
AU  - Samarakoon SR
AUID- ORCID: 0000-0002-5278-4770
AD  - Institute of Biochemistry, Molecular Biology and Biotechnology, University of 
      Colombo, Colombo, Sri Lanka.
FAU - Fronczek, Frank R
AU  - Fronczek FR
AUID- ORCID: 0000-0001-5544-2779
AD  - Department of Chemistry, Louisiana State University, Baton Rouge 70803, 
      Louisiana, USA.
FAU - Sameera, W M C
AU  - Sameera WMC
AUID- ORCID: 0000-0003-0213-0688
AD  - Institute of Low Temperature Science, Hokkaido University, N19-W8 Kita-ku, 
      Sapporo, 060-0819, Hokkaido, Japan.
FAU - Perera, Inoka C
AU  - Perera IC
AUID- ORCID: 0000-0002-2496-7385
AD  - Department of Zoology and Environment Sciences, University of Colombo, Colombo, 
      Sri Lanka.
FAU - Perera, Theshini
AU  - Perera T
AUID- ORCID: 0000-0002-0624-4984
AD  - Department of Chemistry, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
LA  - eng
PT  - Journal Article
DEP - 20220913
PL  - Egypt
TA  - Bioinorg Chem Appl
JT  - Bioinorganic chemistry and applications
JID - 101200445
PMC - PMC9489406
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/13
CRDT- 2022/09/23 02:46
PHST- 2022/04/10 00:00 [received]
PHST- 2022/07/11 00:00 [revised]
PHST- 2022/07/23 00:00 [accepted]
PHST- 2022/09/23 02:46 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/13 00:00 [pmc-release]
AID - 10.1155/2022/7821284 [doi]
PST - epublish
SO  - Bioinorg Chem Appl. 2022 Sep 13;2022:7821284. doi: 10.1155/2022/7821284. 
      eCollection 2022.