PMID- 36147784
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220924
IS  - 2160-200X (Print)
IS  - 2160-200X (Electronic)
IS  - 2160-200X (Linking)
VI  - 12
IP  - 4
DP  - 2022
TI  - Cardiac autonomic dysfunctions in type 2 diabetes mellitus: an investigative 
      study with heart rate variability measures.
PG  - 224-232
AB  - Cardiac autonomic neuropathy (CAN) is a common yet underdiagnosed complication of 
      Type 2 diabetes mellitus (T2DM). Heart rate variability (HRV), a sensitive 
      diagnostic marker of cardiovascular risk, could help detect CAN at its earliest 
      stage. However, the progression of CAN based on age and disease duration in T2DM 
      is lacking. In this study, we propose to explore the occurrence of CAN in 
      patients with varying stages and duration of T2DM. This cross-sectional study 
      involves participants with T2DM (n = 160) and healthy volunteers (n = 40) with an 
      age range of 30-60 years of both genders. Patients in the T2DM group were further 
      subdivided into four subgroups based on their disease duration [Prediabetes, 
      disease duration <5 yrs (D1), 5-10 yrs (D2), and >10 yrs (D3)]. All participants 
      underwent short-term HRV recording for 20 minutes and analyzed for both time and 
      frequency domain measures. The study results showed a significant increase in 
      Heart Rate (HR) in D1 (P = 0.031) and D3 (P = 0.001) groups compared to healthy 
      controls. The time-domain measures of HRV were significantly reduced in the T2DM 
      group compared to the healthy controls. Furthermore, this reduction is more 
      intense in the D3 group than in D2 and D1. Correspondingly, in frequency domain 
      parameters: total power, high-frequency power, and low-frequency power were 
      significantly reduced in all the T2DM groups compared to healthy controls. The 
      study concludes that the overall HRV (as determined by total power), sympathetic 
      activity (low frequency power) and parasympathetic activity (time domain measures 
      and high frequency power) were significantly reduced in all the diabetic 
      subgroups except prediabetes as compared to the healthy controls, implying that 
      both sympathetic and parasympathetic limbs are symmetrically affected in T2DM 
      patients even in the earliest stages (<5 yrs) implying subclinical cardiac 
      autonomic dysfunction in the earliest stages.
CI  - AJCD Copyright (c) 2022.
FAU - John, Anu Panackal Purackal
AU  - John APP
AD  - Department of Neurophysiology, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
FAU - Udupa, Kaviraja
AU  - Udupa K
AD  - Department of Neurophysiology, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
FAU - Avangapur, Santhosh
AU  - Avangapur S
AD  - Department of Neurophysiology, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
FAU - Sujan, Magadi Umeshchandra
AU  - Sujan MU
AD  - Department of Neurophysiology, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
AD  - Current affiliations: Department of Yoga, JSS Academy of Higher Education & 
      Research, Mysuru (Deemed to be University) India.
FAU - Inbaraj, Ganagarajan
AU  - Inbaraj G
AD  - Department of Neurophysiology, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
FAU - Vasuki, Prathyusha Parthipulli
AU  - Vasuki PP
AD  - Department of Biostatistics, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
FAU - Mahadevan, Anita
AU  - Mahadevan A
AD  - Department of Neuropathology, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
FAU - Anilkumar, Rudramunisetty
AU  - Anilkumar R
AD  - Karnataka Institute of Endocrinology and Research (KIER), Diabetology Bangalore, 
      India.
FAU - Shekar, Mysore AnkeGowda
AU  - Shekar MA
AD  - Karnataka Institute of Endocrinology and Research (KIER), Diabetology Bangalore, 
      India.
FAU - Sathyaprabha, Talakad Narasappa
AU  - Sathyaprabha TN
AD  - Department of Neurophysiology, National Institute of Mental Health and 
      Neurosciences Bangalore, India.
LA  - eng
PT  - Journal Article
DEP - 20220815
PL  - United States
TA  - Am J Cardiovasc Dis
JT  - American journal of cardiovascular disease
JID - 101569582
PMC - PMC9490161
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - cardiac autonomic neuropathy
OT  - heart rate
OT  - heart rate variability
OT  - sympathetic and parasympathetic activity
OT  - type 2 diabetes mellitus
COIS- None.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/08/15
CRDT- 2022/09/23 02:47
PHST- 2022/04/11 00:00 [received]
PHST- 2022/06/27 00:00 [accepted]
PHST- 2022/09/23 02:47 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/08/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Cardiovasc Dis. 2022 Aug 15;12(4):224-232. eCollection 2022.