PMID- 36147981
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230123
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 13
DP  - 2022
TI  - The alternations of nucleus accumbent in schizophrenia patients with auditory 
      verbal hallucinations during low-frequency rTMS treatment.
PG  - 971105
LID - 10.3389/fpsyt.2022.971105 [doi]
LID - 971105
AB  - Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been shown 
      to reduce the severity of auditory verbal hallucinations (AVH) and induce 
      beneficial functional and structural alternations of the brain in schizophrenia 
      patients with AVH. The nucleus accumbens (NAcc) as an important component of the 
      ventral striatum is implicated with the pathology in AVH. However, the induced 
      characteristic patterns of NAcc by low-frequency rTMS in schizophrenia with AVH 
      are seldom explored. We investigated the functional and structural characteristic 
      patterns of NAcc by using seed-based functional connectivity (FC) analysis and 
      gray matter volume (GMV) measurement in schizophrenia patients with AVH during 1 
      Hz rTMS treatment. Although low-frequency rTMS treatment did not affect the 
      volumetric changes of NAcc, the abnormal FC patterns of NAcc, including increased 
      FC of NAcc with the temporal lobes and decreased FC of NAcc with the frontal 
      cortices in the pretreatment patients compared to healthy controls, were 
      normalized or reversed after treatment. These FC changes were associated with 
      improvements in clinical symptoms and neurocognitive functions. Our findings may 
      extend our understanding of the NAcc in the pathology of schizophrenia with AVH 
      and might be a biomarker of clinical effect for low-frequency rTMS treatment in 
      schizophrenia.
CI  - Copyright (c) 2022 Xie, Cai, Guan, Wang, Ma, Fang and Wang.
FAU - Xie, Yuanjun
AU  - Xie Y
AD  - School of Education, Xinyang College, Xinyang, China.
AD  - Department of Radiology, Xijing Hospital, Air Force Medical University, Xi'an, 
      China.
FAU - Cai, Yun
AU  - Cai Y
AD  - Department of Neurodevelopment Psychology, School of Psychology, Army Medical 
      University, Chongqing, China.
FAU - Guan, Muzhen
AU  - Guan M
AD  - Department of Mental Health, Xi'an Medical University, Xi'an, China.
FAU - Wang, Zhongheng
AU  - Wang Z
AD  - Department of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, 
      China.
FAU - Ma, Zhujing
AU  - Ma Z
AD  - Department of Clinical Psychology, Air Force Medical University, Xi'an, China.
FAU - Fang, Peng
AU  - Fang P
AD  - Department of Military Medical Psychology, Air Force Medical University, Xi'an, 
      China.
FAU - Wang, Huaning
AU  - Wang H
AD  - Department of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220906
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
EIN - Front Psychiatry. 2023 Jan 04;13:1118275. PMID: 36683987
PMC - PMC9485869
OTO - NOTNLM
OT  - auditory verbal hallucination
OT  - functional connectivity
OT  - gray matter volume
OT  - nucleus accumbent
OT  - repetitive transcranial magnetic stimulation
OT  - schizophrenia
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/24 06:00
MHDA- 2022/09/24 06:01
PMCR- 2022/09/06
CRDT- 2022/09/23 02:51
PHST- 2022/06/16 00:00 [received]
PHST- 2022/08/16 00:00 [accepted]
PHST- 2022/09/23 02:51 [entrez]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/09/24 06:01 [medline]
PHST- 2022/09/06 00:00 [pmc-release]
AID - 10.3389/fpsyt.2022.971105 [doi]
PST - epublish
SO  - Front Psychiatry. 2022 Sep 6;13:971105. doi: 10.3389/fpsyt.2022.971105. 
      eCollection 2022.