PMID- 36150176
OWN - NLM
STAT- MEDLINE
DCOM- 20221006
LR  - 20221006
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 70
IP  - 39
DP  - 2022 Oct 5
TI  - Ameliorating Effect of the Total Flavonoids of Morus nigra L. on Prediabetic Mice 
      Based on Regulation of Inflammation and Insulin Sensitization.
PG  - 12484-12501
LID - 10.1021/acs.jafc.2c04970 [doi]
AB  - Prediabetes is a critical stage characterized by insulin resistance. Morus nigra 
      L., an edible plant, is widely used in food and nutritive supplements and 
      exhibits various pharmacological activities; however, its therapeutic effects and 
      mechanisms on prediabetes have rarely been reported. In this research, the major 
      components of total flavonoids of M. nigra L. (TFM) were identified, and TFM 
      treatment was found to reduce prediabetes progressing to type 2 diabetes mellitus 
      (T2DM) from 93.75 to 18.75%. The microbiota and next-generation sequencing 
      combined with western blotting in vivo and in vitro demonstrated that TFM and its 
      components ameliorated insulin resistance mediated by the suppressor of cytokine 
      signaling and protein tyrosine phosphatase 1B, which benefited by maintaining 
      intestinal homeostasis and restraining plasma levels of inflammatory factors. 
      This study confirmed the T2DM prevention effect of TFM and revealed the 
      underlying mechanism, setting the stage for the design of functional foods for 
      diabetes prevention.
FAU - Ren, Xinxiu
AU  - Ren X
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Sun, Yu
AU  - Sun Y
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Guo, Qinfeng
AU  - Guo Q
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Liu, Haodong
AU  - Liu H
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Jiang, Hui
AU  - Jiang H
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - He, Xiaoshi
AU  - He X
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Li, Xia
AU  - Li X
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Shi, Xuan
AU  - Shi X
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Xiu, Zhilong
AU  - Xiu Z
AUID- ORCID: 0000-0002-1150-658X
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
FAU - Dong, Yuesheng
AU  - Dong Y
AUID- ORCID: 0000-0001-5010-6426
AD  - School of Bioengineering, Dalian University of Technology, Dalian 116024, 
      Liaoning, China.
LA  - eng
PT  - Journal Article
DEP - 20220923
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Cytokines)
RN  - 0 (Flavonoids)
RN  - 0 (Insulin)
RN  - 0 (Plant Extracts)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
SB  - IM
MH  - Animals
MH  - Cytokines
MH  - *Diabetes Mellitus, Type 2/drug therapy/genetics
MH  - Flavonoids/pharmacology
MH  - Inflammation
MH  - Insulin
MH  - *Insulin Resistance
MH  - Mice
MH  - *Morus
MH  - Plant Extracts/pharmacology
MH  - *Prediabetic State/drug therapy
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 1
OTO - NOTNLM
OT  - Morus nigra L.
OT  - flavonoids
OT  - inflammatory factors
OT  - insulin resistance
OT  - prediabetes
EDAT- 2022/09/24 06:00
MHDA- 2022/10/07 06:00
CRDT- 2022/09/23 17:12
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/10/07 06:00 [medline]
PHST- 2022/09/23 17:12 [entrez]
AID - 10.1021/acs.jafc.2c04970 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2022 Oct 5;70(39):12484-12501. doi: 10.1021/acs.jafc.2c04970. 
      Epub 2022 Sep 23.