PMID- 36150631
OWN - NLM
STAT- MEDLINE
DCOM- 20221129
LR  - 20230207
IS  - 1873-5169 (Electronic)
IS  - 0196-9781 (Linking)
VI  - 158
DP  - 2022 Dec
TI  - Effects of maternal deprivation and environmental enrichment on anxiety-like and 
      depression-like behaviors correlate with oxytocin system and CRH level in the 
      medial-lateral habenula.
PG  - 170882
LID - S0196-9781(22)00148-6 [pii]
LID - 10.1016/j.peptides.2022.170882 [doi]
AB  - The medial-lateral habenula (LHbM)'s role in anxiety and depression behaviors in 
      female mice remains unclear. Here, we used neonatal maternal deprivation (MD) and 
      post-weaning environmental enrichment (EE) to treat female BALB/c offspring and 
      checked anxiety-like and depression-like behaviors as well as the 
      corticotropin-releasing hormone (CRH), oxytocin receptor (OTR), estrogen 
      receptor-beta (ERbeta) levels in their LHbM at adulthood. We found that MD enhanced 
      state anxiety-like behaviors in the elevated plus-maze test, and EE caused trait 
      anxiety-like behaviors in the open field test and depression-like behaviors in 
      the tail suspension test. The immunochemistry showed that MD reduced OT 
      immunoreactive neuron numbers in the hypothalamic paraventricular nucleus but 
      increased OTR levels in the LHbM; EE increased CRH levels in the LHbM but 
      decreased OTR levels in the LHbM. The additive effects of EE and MD maintained 
      the behavioral parameters, OT-ir neuronal numbers, CRH levels, and OTR levels 
      similar to the additive of non-MD and non-EE. The correlation analysis showed 
      that CRH levels correlated with synaptic connection levels, OTR levels correlated 
      with nucleus densities, and ERbeta levels correlated with Nissl body levels and body 
      weights in female mice. Neither MD nor EE affected ERbeta levels in the LHbM. 
      Together, the study revealed the relationships between behaviors and 
      neuroendocrine and neuronal alterations in female LHbM and the effects of 
      experiences including MD and EE on them.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Wei, Fengmei
AU  - Wei F
AD  - Department of Physiology and Psychology, School of Basic Medical Sciences, 
      Lanzhou University, Lanzhou, Gansu Province 730000, PR China; Institute of 
      Anatomy and Histology & Embryology, Neuroscience, School of Basic Medical 
      Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China. Electronic 
      address: weifm@lzu.edu.cn.
FAU - Xian, Donghua
AU  - Xian D
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - He, Yunqing
AU  - He Y
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - Yan, Ziqing
AU  - Yan Z
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - Deng, Xiao
AU  - Deng X
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - Chen, Yajie
AU  - Chen Y
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - Zhao, Long
AU  - Zhao L
AD  - Department of Orthopedics, Lanzhou University First Affiliated Hospital, Lanzhou, 
      Gansu Province 730000, PR China.
FAU - Zhang, Yishu
AU  - Zhang Y
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - Li, Wenhao
AU  - Li W
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - Ma, Bo
AU  - Ma B
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China.
FAU - Zhang, Junfeng
AU  - Zhang J
AD  - Department of Human Anatomy & Shanxi Key Laboratory of Brain Disorders, Xi'an 
      Medical University, Xi'an, Shanxi, 710021, PR China. Electronic address: 
      Zhangjf_08@126.com.
FAU - Jing, Yuhong
AU  - Jing Y
AD  - Institute of Anatomy and Histology & Embryology, Neuroscience, School of Basic 
      Medical Sciences, Lanzhou University, Lanzhou, Gansu 730000, PR China; Key 
      Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou 
      University, Lanzhou, Gansu 730000, PR China. Electronic address: 
      jingyh@lzu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220921
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 50-56-6 (Oxytocin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Oxytocin)
SB  - IM
MH  - Animals
MH  - Female
MH  - Mice
MH  - *Oxytocin/pharmacology
MH  - Corticotropin-Releasing Hormone
MH  - Maternal Deprivation
MH  - Estrogen Receptor beta/genetics
MH  - *Habenula/metabolism
MH  - Depression
MH  - Receptors, Oxytocin/genetics
MH  - Anxiety
OTO - NOTNLM
OT  - Corticotropin-releasing hormone
OT  - Depression-like behaviors
OT  - Environmental enrichment
OT  - Lateral habenula
OT  - Maternal deprivation
OT  - Oxytocin receptor
COIS- Declaration of interests None.
EDAT- 2022/09/24 06:00
MHDA- 2022/11/30 06:00
CRDT- 2022/09/23 19:35
PHST- 2022/06/09 00:00 [received]
PHST- 2022/08/25 00:00 [revised]
PHST- 2022/09/17 00:00 [accepted]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2022/11/30 06:00 [medline]
PHST- 2022/09/23 19:35 [entrez]
AID - S0196-9781(22)00148-6 [pii]
AID - 10.1016/j.peptides.2022.170882 [doi]
PST - ppublish
SO  - Peptides. 2022 Dec;158:170882. doi: 10.1016/j.peptides.2022.170882. Epub 2022 Sep 
      21.