PMID- 36151442
OWN - NLM
STAT- MEDLINE
DCOM- 20230222
LR  - 20230222
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 42
IP  - 3
DP  - 2023 Mar
TI  - Coexistence of fibromyalgia syndrome and inflammatory rheumatic diseases, and 
      autonomic cardiovascular system involvement in fibromyalgia syndrome.
PG  - 645-652
LID - 10.1007/s10067-022-06385-8 [doi]
AB  - The spectrum of symptoms represented by fibromyalgia syndrome (FMS) has a 
      profound effect on daily activities and impairs the quality of life. A 
      considerable proportion of patients with inflammatory rheumatic diseases (IRDs) 
      fulfill the FMS criteria, which can complicate the diagnosis, treatment, and 
      follow-ups of IRD. In addition, the coexistence of FMS may cause unnecessary 
      laboratory and radiological assessments. Several mechanisms have been proposed 
      that may have a role in the etiopathogenesis of FMS, one of which is autonomic 
      dysregulation. In studies evaluating cardiac autonomic dysfunction based on heart 
      rate variability (HRV), there has been found to be a decrease in HRV and 
      dominance of the sympathetic nervous system. Autonomic reactivity reflects 
      modulations of several functions to overcome the existing state and conditions. 
      Blunted autonomic reactivity has been found in some FMS patients, which makes it 
      difficult for these patients to respond appropriately to unexpected stress 
      sources that occur during daily living activities. Baroreceptor signals have an 
      inhibitory influence on the central nervous system, and these impulses cause pain 
      suppression. From this perspective, there are studies that have suggested the 
      involvement of diminished baroreflex sensitivity in the etiology of FMS. The risk 
      of endothelial dysfunction and increased arterial stiffness have been shown to 
      occur in FMS patients due to autonomic dysfunction, sympathetic nervous system 
      dominance, chronic stress, and pain. There is also evidence linking FMS with the 
      risk of atrial and ventricular arrhythmias. Considering all these cardiovascular 
      autonomic dysfunctions, tests that can confirm abnormalities should be performed 
      when suspicion arises. There is a need for specific pharmacological and 
      non-pharmacological treatment alternatives to be identified for subgroups of 
      patients with cardiovascular system abnormalities. Key points * The frequency of 
      FMS accompanying inflammatory rheumatic diseases is considerable and this 
      coexistence leads to troubles in evaluating treatment response and determining 
      appropriate medical treatment options in inflammatory rheumatic diseases. * 
      Various cardiovascular autonomic abnormalities have been described in FMS 
      patients. Among these, the most emphasized are autonomic dysfunction, the 
      disruption of the balance between the sympathetic-parasympathetic nervous 
      systems, blunted autonomic reactivity to acute stress, changes in baroreflex 
      sensitivity, increased arterial stiffness, and electrophysiological alterations. 
      * Autonomic cardiovascular dysfunction may be involved in the complex 
      etiopathogenesis of the fibromyalgia syndrome and may trigger at least some 
      symptoms.
CI  - (c) 2022. The Author(s), under exclusive licence to International League of 
      Associations for Rheumatology (ILAR).
FAU - Kocyigit, Burhan Fatih
AU  - Kocyigit BF
AUID- ORCID: 0000-0002-6065-8002
AD  - Faculty of Medicine, Department of Physical Medicine and Rehabilitation, 
      Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. bfk2701@hotmail.com.
FAU - Akyol, Ahmet
AU  - Akyol A
AUID- ORCID: 0000-0002-8953-5196
AD  - Physiotherapy and Rehabilitation Application and Research Center, Hasan Kalyoncu 
      University, Gaziantep, Turkey.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220923
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
SB  - IM
MH  - Humans
MH  - *Fibromyalgia
MH  - Quality of Life
MH  - *Cardiovascular System
MH  - Heart/diagnostic imaging
MH  - Pain/complications
MH  - Heart Rate/physiology
MH  - *Rheumatic Fever
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - Cardiovascular abnormality
OT  - Dysautonomia
OT  - Fibromyalgia
OT  - Rheumatic diseases
EDAT- 2022/09/24 06:00
MHDA- 2023/02/22 06:00
CRDT- 2022/09/23 23:37
PHST- 2022/08/13 00:00 [received]
PHST- 2022/09/20 00:00 [accepted]
PHST- 2022/09/16 00:00 [revised]
PHST- 2022/09/24 06:00 [pubmed]
PHST- 2023/02/22 06:00 [medline]
PHST- 2022/09/23 23:37 [entrez]
AID - 10.1007/s10067-022-06385-8 [pii]
AID - 10.1007/s10067-022-06385-8 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2023 Mar;42(3):645-652. doi: 10.1007/s10067-022-06385-8. Epub 
      2022 Sep 23.