PMID- 36153757
OWN - NLM
STAT- MEDLINE
DCOM- 20230329
LR  - 20230329
IS  - 1573-2630 (Electronic)
IS  - 0165-5701 (Linking)
VI  - 43
IP  - 3
DP  - 2023 Mar
TI  - In vivo confocal microscopy of sub-basal corneal nerves and corneal densitometry 
      after three kinds of refractive procedures for high myopia.
PG  - 925-935
LID - 10.1007/s10792-022-02494-0 [doi]
AB  - PURPOSE: To observe corneal nerve fibers and densitometry after small incision 
      lenticule extraction (SMILE), femtosecond laser-assisted laser in situ 
      keratomileusis (FS-LASIK) and laser-assisted subepithelial keratomileusis (LASEK) 
      for high myopia. METHODS: This is a prospective, cross-sectional research study. 
      Patients with high myopia (equivalent spherical lens: -6.00 and -11.00D) who 
      underwent laser corneal refractive surgery were divided into three groups: SMILE, 
      FS-LASIK and LASEK. Scheimpflug imaging of corneal nerves in five areas was 
      observed by confocal microscopy before and 6, 12 months after surgery. Corneal 
      densitometry was measured by Pentacam anterior segment analysis system. RESULTS: 
      Overall, 59 patients were enrolled. The nerve density in the central area did not 
      recover to the preoperative level in three groups until 12 months. The density 
      and length of corneal nerves in central and lower area were better in the SMILE 
      group 6 months postoperatively (p = 0.01), while nerve density did not differ 
      significantly among three groups 12 months postoperatively (p = 0.18). Nerve 
      fibers in central and temporal region were wider in LASEK than that in other two 
      groups at 6- and 12-month follow-up. Corneal densitometry in the central 6 mm 
      diameter was significantly higher in the LASEK group compared with other two 
      groups 6 months postoperatively (p = 0.04). Twelve months postoperatively, 
      corneal densitometry in range of all zone was lower in SMILE than in FS-LASIK and 
      LASEK (p = 0.01, 0.03, 0.04). CONCLUSIONS: Compared with FS-LASIK and LASEK, 
      SMILE-treated eyes with high myopia had certain advantages in nerve density, 
      length and nerve connection way and had better corneal transparency after 
      operation.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Hou, Chenting
AU  - Hou C
AD  - Department of Ophthalmology, The Affiliated Hospital of Qingdao University, No.16 
      Jiangsu Road, Qingdao, 266000, Shandong Province, China.
FAU - Li, Jiangfeng
AU  - Li J
AD  - Department of Ophthalmology, The Affiliated Hospital of Qingdao University, No.16 
      Jiangsu Road, Qingdao, 266000, Shandong Province, China.
AD  - Affiliated Aier Eye Hospital of Jinan University, Shenzhen, Guangzhou Province, 
      China.
FAU - Li, Jinjian
AU  - Li J
AD  - Department of Ophthalmology, The Affiliated Hospital of Qingdao University, No.16 
      Jiangsu Road, Qingdao, 266000, Shandong Province, China.
FAU - Peng, Hui
AU  - Peng H
AD  - Department of Ophthalmology, The Affiliated Hospital of Qingdao University, No.16 
      Jiangsu Road, Qingdao, 266000, Shandong Province, China.
FAU - Wang, Qing
AU  - Wang Q
AUID- ORCID: 0000-0003-1341-6104
AD  - Department of Ophthalmology, The Affiliated Hospital of Qingdao University, No.16 
      Jiangsu Road, Qingdao, 266000, Shandong Province, China. wangqing6836@sina.com.
LA  - eng
GR  - ZR2019MH115/Natural Science Foundation of Shandong Province/
PT  - Journal Article
DEP - 20220925
PL  - Netherlands
TA  - Int Ophthalmol
JT  - International ophthalmology
JID - 7904294
SB  - IM
MH  - Humans
MH  - Corneal Stroma/surgery
MH  - Prospective Studies
MH  - Cross-Sectional Studies
MH  - Visual Acuity
MH  - Lasers, Excimer
MH  - Cornea/surgery
MH  - *Keratomileusis, Laser In Situ/methods
MH  - *Myopia/diagnosis/surgery
MH  - Microscopy, Confocal
MH  - Densitometry
OTO - NOTNLM
OT  - Corneal nerve
OT  - Densitometry
OT  - High myopia
OT  - In vivo confocal microscope
OT  - Laser corneal refractive surgery
EDAT- 2022/09/26 06:00
MHDA- 2023/03/29 06:05
CRDT- 2022/09/25 13:54
PHST- 2021/12/11 00:00 [received]
PHST- 2022/08/20 00:00 [accepted]
PHST- 2023/03/29 06:05 [medline]
PHST- 2022/09/26 06:00 [pubmed]
PHST- 2022/09/25 13:54 [entrez]
AID - 10.1007/s10792-022-02494-0 [pii]
AID - 10.1007/s10792-022-02494-0 [doi]
PST - ppublish
SO  - Int Ophthalmol. 2023 Mar;43(3):925-935. doi: 10.1007/s10792-022-02494-0. Epub 
      2022 Sep 25.