PMID- 36155088
OWN - NLM
STAT- MEDLINE
DCOM- 20221116
LR  - 20231202
IS  - 1532-2785 (Electronic)
IS  - 0143-4179 (Print)
IS  - 0143-4179 (Linking)
VI  - 96
DP  - 2022 Dec
TI  - Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens 
      decreases appetitive and consumptive responding for food.
PG  - 102289
LID - S0143-4179(22)00064-6 [pii]
LID - 10.1016/j.npep.2022.102289 [doi]
AB  - RATIONALE: Obesity is a major health problem worldwide. An understanding of the 
      factors that drive feeding behaviors is key to the development of pharmaceuticals 
      to decrease appetite and consumption. Proopiomelanocortin (POMC), the 
      melanocortin peptide precursor, is essential in the regulation of body weight and 
      ingestive behaviors. Deletion of POMC or impairment of melanocortin signaling in 
      the brain results in hyperphagic obesity. Neurons in the hypothalamic arcuate 
      nucleus produce POMC and project to many areas including the nucleus accumbens 
      (NAcc), which is well established in the rewarding and reinforcing effects of 
      both food and drugs of abuse. OBJECTIVE: These studies sought to determine the 
      role of melanocortins in the NAcc on consumption of and motivation to obtain 
      access to standard rodent chow. METHODS: Male, C57BL/6J mice were microinjected 
      bilaterally into the NAcc (100 nl/side) with the melanocortin receptor 3/4 
      agonist melanotan-II (MT-II; 0.1, 0.3, and 1 nmol), and ingestive behaviors were 
      examined in both home cage and operant food self-administration experiments. In 
      addition, the ability of MT-II in the NAcc to produce aversive properties or 
      affect metabolic rate were tested. RESULTS: MT-II injected into the NAcc 
      significantly decreased consumption in both home cage and operant paradigms, and 
      furthermore decreased appetitive responding to gain access to food. There was no 
      development of conditioned taste avoidance or change in metabolic parameters 
      following anorexic doses of MT-II. CONCLUSIONS: MT-II in the NAcc decreased both 
      the motivation to eat and the amount of food consumed without inducing an 
      aversive state or affecting metabolic rate, suggesting a role for melanocortin 
      signaling in the NAcc that is selective for appetite and satiety without 
      affecting metabolism or producing an aversive state.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Eliason, Nicole L
AU  - Eliason NL
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, University of 
      Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America.
FAU - Martin, Lynne
AU  - Martin L
AD  - Department of Pharmaceutical Sciences, Feik College of Pharmacy, University of 
      the Incarnate Word, San Antonio, TX, United States of America.
FAU - Low, Malcolm J
AU  - Low MJ
AD  - Department of Molecular & Integrative Physiology, University of Michigan Medical 
      School, Ann Arbor, MI, United States of America.
FAU - Sharpe, Amanda L
AU  - Sharpe AL
AD  - Department of Pharmaceutical Sciences, College of Pharmacy, University of 
      Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America; 
      Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, 
      Oklahoma City, OK, United States of America. Electronic address: 
      Amanda-Sharpe@ouhsc.edu.
LA  - eng
GR  - R01 DK066604/DK/NIDDK NIH HHS/United States
GR  - R56 DK066604/DK/NIDDK NIH HHS/United States
GR  - P30 DK020572/DK/NIDDK NIH HHS/United States
GR  - SC3 GM121214/GM/NIGMS NIH HHS/United States
GR  - P20 GM125528/GM/NIGMS NIH HHS/United States
PT  - Journal Article
DEP - 20220916
PL  - Netherlands
TA  - Neuropeptides
JT  - Neuropeptides
JID - 8103156
RN  - 0 (Melanocortins)
RN  - 121062-08-6 (melanotan-II)
RN  - 66796-54-1 (Pro-Opiomelanocortin)
RN  - 0 (Receptor, Melanocortin, Type 4)
RN  - 0 (Peptides, Cyclic)
RN  - 581-05-5 (alpha-MSH)
SB  - IM
MH  - Animals
MH  - Male
MH  - Mice
MH  - Melanocortins/metabolism
MH  - Mice, Inbred C57BL
MH  - *Nucleus Accumbens
MH  - Obesity
MH  - *Pro-Opiomelanocortin/metabolism
MH  - *Receptor, Melanocortin, Type 4/agonists
MH  - *Peptides, Cyclic/pharmacology
MH  - *alpha-MSH/analogs & derivatives/pharmacology
PMC - PMC10152796
MID - NIHMS1845023
OTO - NOTNLM
OT  - Appetite
OT  - Conditioned taste avoidance
OT  - Feeding behavior
OT  - Melanocortin receptor
OT  - Satiety
COIS- Declaration of Competing Interest The authors have no conflicts of interest to 
      disclose.
EDAT- 2022/09/27 06:00
MHDA- 2022/11/15 06:00
PMCR- 2023/12/01
CRDT- 2022/09/26 15:16
PHST- 2022/04/13 00:00 [received]
PHST- 2022/08/20 00:00 [revised]
PHST- 2022/09/13 00:00 [accepted]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/11/15 06:00 [medline]
PHST- 2022/09/26 15:16 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - S0143-4179(22)00064-6 [pii]
AID - 10.1016/j.npep.2022.102289 [doi]
PST - ppublish
SO  - Neuropeptides. 2022 Dec;96:102289. doi: 10.1016/j.npep.2022.102289. Epub 2022 Sep 
      16.