PMID- 36156816
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20221025
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 33
IP  - 9
DP  - 2022 Sep
TI  - Relevance of sensitization to legumes in peanut-allergic children.
PG  - e13846
LID - 10.1111/pai.13846 [doi]
LID - e13846
AB  - BACKGROUND: Legume consumption has increased during the two past decades. In 
      France, legumes are responsible for 14.6% of food-related anaphylaxis in 
      children, with peanut as the main allergen (77.5%). Few studies have demonstrated 
      cross-reactivities between peanut and other legumes. The aim of this study was to 
      determine prevalence and relevance of sensitization to legumes in peanut-allergic 
      children. METHODS: All children, aged of 1-17 years, admitted to the Pediatric 
      Allergy Department of the University Hospital of Nancy between January 1, 2017 
      and February 29, 2020 with a confirmed peanut allergy (PA) and a documented 
      consumption or sensitization to at least one other legume were included. Data 
      were retrospectively collected regarding history of consumption, skin prick 
      tests, specific immunoglobulin E (IgE), prior allergic reactions, and oral food 
      challenges for each legume. RESULTS: Among the 195 included children with PA, 122 
      were sensitized to at least one other legume (63.9%). Main sensitizations were 
      for fenugreek (N = 61, 66.3%), lentil (N = 38, 42.2%), soy (N = 61, 39.9%), and 
      lupine (N = 63, 34.2%). Among the 122 sensitized children, allergy to at least 
      one legume was confirmed for 34 children (27.9%), including six children who had 
      multiple legume allergies (4.9%). Lentil, lupine, and pea were the main 
      responsible allergens. Half of allergic reactions to legumes other than peanut 
      were severe. CONCLUSION: The high prevalence of legume sensitization and the 
      frequent severe reactions reported in children with PA highlight that tolerated 
      legume consumption should be explored for each legume in the case of PA, and 
      sensitization should be investigated if not.
CI  - (c) 2022 The Authors. Pediatric Allergy and Immunology published by European 
      Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
FAU - Muller, Time
AU  - Muller T
AD  - Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, 
      Vandoeuvre-les-Nancy, France.
FAU - Luc, Amandine
AU  - Luc A
AD  - DRCI, MPI Department, Methodology, Data Management and Statistics Unit, 
      University Hospital of Nancy, Vandoeuvre-les-Nancy, France.
FAU - Adam, Tania
AU  - Adam T
AD  - Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, 
      Vandoeuvre-les-Nancy, France.
FAU - Jarlot-Chevaux, Sophie
AU  - Jarlot-Chevaux S
AD  - Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, 
      Vandoeuvre-les-Nancy, France.
FAU - Dumond, Pascale
AU  - Dumond P
AD  - Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, 
      Vandoeuvre-les-Nancy, France.
FAU - Schweitzer, Cyril
AU  - Schweitzer C
AD  - Department of Pediatric Lung Function Testing, Children's Hospital, University 
      Hospital of Nancy, Vandoeuvre-les-Nancy, France.
AD  - EA3450 DevAH - Department of Physiology, Faculty of Medicine, University of 
      Lorraine, Vandoeuvre-les-Nancy, France.
FAU - Codreanu-Morel, Francoise
AU  - Codreanu-Morel F
AD  - National Department of Allergy, Hospital Centre of Luxembourg, Luxembourg, 
      Luxembourg.
FAU - Divaret-Chauveau, Amandine
AU  - Divaret-Chauveau A
AUID- ORCID: 0000-0002-2492-9864
AD  - Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, 
      Vandoeuvre-les-Nancy, France.
AD  - EA3450 DevAH - Department of Physiology, Faculty of Medicine, University of 
      Lorraine, Vandoeuvre-les-Nancy, France.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - *Anaphylaxis
MH  - Arachis
MH  - Child
MH  - *Food Hypersensitivity/diagnosis/epidemiology
MH  - Humans
MH  - Immunoglobulin E
MH  - *Lens Plant
MH  - *Lupinus
MH  - *Peanut Hypersensitivity/diagnosis/epidemiology
MH  - Retrospective Studies
MH  - Skin Tests
MH  - Vegetables
PMC - PMC9544501
OTO - NOTNLM
OT  - allergy
OT  - children
OT  - cross-reactions
OT  - legumes
OT  - peanut
OT  - sensitization
COIS- The authors declare no conflict of interest.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/10/07
CRDT- 2022/09/26 16:54
PHST- 2022/07/31 00:00 [revised]
PHST- 2022/03/01 00:00 [received]
PHST- 2022/08/15 00:00 [accepted]
PHST- 2022/09/26 16:54 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/10/07 00:00 [pmc-release]
AID - PAI13846 [pii]
AID - 10.1111/pai.13846 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2022 Sep;33(9):e13846. doi: 10.1111/pai.13846.