PMID- 36156882
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220928
IS  - 1984-3143 (Electronic)
IS  - 1806-9614 (Print)
IS  - 1806-9614 (Linking)
VI  - 19
IP  - 3
DP  - 2022
TI  - Oxidative stress, ceruloplasmin and neopterin biomarkers in dromedary camels with 
      clinical endometritis.
PG  - e20220035
LID - 10.1590/1984-3143-AR2022-0035 [doi]
LID - e20220035
AB  - The purpose of this study is to investigate the role of some oxidative stress 
      (OS), ceruloplasmin (Cp), and neopterin (NPT) as diagnostic biomarkers for 
      dromedary camels endometritis as well as to explore the impact of ceftiofur 
      treatment on endometritis. Camels were categorized into two groups; healthy 
      control group (n = 20) and endometritis group (n = 60). She-camels with clinical 
      signs of endometritis (CE) received 6.6 mg/kg BW of ceftiofur (i/m). On days 7, 
      and 14, she-camels were evaluated and clinical cure or failure to cure was 
      determined. The comparison of the groups for OS demonstrated that endometritis 
      caused an increase in serum malondialdehyde (sMDA), Cp, and NPT levels (P<0.05), 
      but decreased serum levels of superoxide dismutase (SOD), catalase (CAT), and 
      glutathione (GSH) (P<0.05). The most prevalent pathogens involved in the etiology 
      of CE are Arcanobacterium pyogenes, Streptococcus pyogenes, and Staphylococcus 
      aureus. All examined biomarkers demonstrated a high degree of recognition between 
      CE camel and healthy controls (the area under the curve (AUC) was 95.9 for NPT). 
      A higher proportion of camels with CE that were treated with ceftiofur (90%, 
      P<0.0001) showed clinical cure by the first dose, while 10% required a second 
      dose. In conclusion, CE causes increased oxidative reactions and decreased 
      antioxidant defense competence. Subsequently, the alteration in that balance that 
      was represented by the biomarkers of OS could be beneficial for clinical practice 
      and basic clinical research. Additionally, all trials demonstrated the efficacy 
      of ceftiofur for the treatment of CE in she-camel.
FAU - El-Deeb, Wael
AU  - El-Deeb W
AUID- ORCID: 0000-0003-2451-296X
AD  - Al Bilad Bank Scholarly Chair for Food Security in Saudi Arabia, Deanship of 
      Scientific Research, Vice Presidency for Graduate Studies and Scientific 
      Research, Al Ahsa, Saudi Arabia.
AD  - Department of Clinical Sciences, College of Veterinary Medicine, King Faisal 
      University, Al-Ahsa, Saudi Arabia.
AD  - Department of Internal Medicine, Infectious Diseases and Fish Diseases, Faculty 
      of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
FAU - Abdelghani, Mohammed Ali
AU  - Abdelghani MA
AUID- ORCID: 0000-0003-4386-4995
AD  - Al Bilad Bank Scholarly Chair for Food Security in Saudi Arabia, Deanship of 
      Scientific Research, Vice Presidency for Graduate Studies and Scientific 
      Research, Al Ahsa, Saudi Arabia.
AD  - Department of Clinical Sciences, College of Veterinary Medicine, King Faisal 
      University, Al-Ahsa, Saudi Arabia.
AD  - Department of Theriogenology, Faculty of Veterinary Medicine, Assuit University, 
      Assuit, Egypt.
FAU - Alhaider, Abdulrahman
AU  - Alhaider A
AUID- ORCID: 0000-0003-3863-997X
AD  - Al Bilad Bank Scholarly Chair for Food Security in Saudi Arabia, Deanship of 
      Scientific Research, Vice Presidency for Graduate Studies and Scientific 
      Research, Al Ahsa, Saudi Arabia.
AD  - Department of Clinical Sciences, College of Veterinary Medicine, King Faisal 
      University, Al-Ahsa, Saudi Arabia.
FAU - Fayez, Mahmoud
AU  - Fayez M
AUID- ORCID: 0000-0002-2145-2714
AD  - Al Ahsa Veterinary Diagnostic Laboratory, Ministry of Environment, Water and 
      Agriculture, Al Ahsa, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20220912
PL  - Brazil
TA  - Anim Reprod
JT  - Animal reproduction
JID - 101272804
PMC - PMC9484399
OTO - NOTNLM
OT  - camel
OT  - ceftiofur
OT  - ceruloplasmin
OT  - endometritis
OT  - neopterin
COIS- Conflicts of interest: The authors have no conflict of interest to declare.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/27 06:01
PMCR- 2022/09/12
CRDT- 2022/09/26 16:58
PHST- 2022/03/11 00:00 [received]
PHST- 2022/08/26 00:00 [accepted]
PHST- 2022/09/26 16:58 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/27 06:01 [medline]
PHST- 2022/09/12 00:00 [pmc-release]
AID - arAO20220035_EN [pii]
AID - 10.1590/1984-3143-AR2022-0035 [doi]
PST - epublish
SO  - Anim Reprod. 2022 Sep 12;19(3):e20220035. doi: 10.1590/1984-3143-AR2022-0035. 
      eCollection 2022.