PMID- 36157466
OWN - NLM
STAT- MEDLINE
DCOM- 20220928
LR  - 20230329
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Prenatal health behaviours as predictors of human placental lactogen levels.
PG  - 946539
LID - 10.3389/fendo.2022.946539 [doi]
LID - 946539
AB  - Placental lactogen (hPL) is a key hormone of pregnancy responsible for inducing 
      maternal adaptations critical for a successful pregnancy. Low levels of placental 
      lactogen have been associated with lower birth weight as well as symptoms of 
      maternal depression and anxiety. Lower placental lactogen has been reported in 
      women with higher body mass index (BMI) but it is unclear whether prenatal health 
      behaviours predict hPL levels or if hPL is associated with infant weight 
      outcomes. This study utilised data from the longitudinal Grown in Wales cohort, 
      based in South Wales. Participants were recruited at the pre-surgical appointment 
      for an elective caesarean section. This study incorporates data from recruitment, 
      post-delivery and a 12 month follow-up. Measures of maternal serum hPL were 
      available for 248 participants. Analysis included unadjusted and adjusted linear 
      and binary regression. Unadjusted, prenatal smoking and a Health Conscious 
      dietary pattern were associated with hPL levels, however this was lost on 
      adjustment for BMI at booking, Welsh Index of Multiple Deprivation (WIMD) score 
      and placental weight. When stratified by maternal BMI at booking, a Health 
      Conscious dietary pattern remained associated with increased hPL levels in women 
      with a healthy BMI (p=.024, B=.59. 95% CI=.08,1.11) following adjustment for WIMD 
      score and placental weight. When adjusted for a wide range of confounders, 
      maternal hPL was also associated with increased custom birthweight centiles 
      (CBWC) (p=.014, B=1.64. 95% CI=.33,2.94) and increased odds of large for 
      gestational age deliveries (p=<.001, Exp(B)=1.42. 95% CI=1.17,1.72). This study 
      identified that consuming a Health Conscious dietary pattern in pregnancy was 
      associated with increased hPL, within women of a healthy BMI. Moreover, higher 
      hPL levels were associated with increased CBWC and increased odds of delivering a 
      large for gestational age infant. This improves the current limited evidence 
      surrounding the nature of hPL in these areas.
CI  - Copyright (c) 2022 Garay, Sumption and John.
FAU - Garay, Samantha M
AU  - Garay SM
AD  - School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom.
FAU - Sumption, Lorna A
AU  - Sumption LA
AD  - School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom.
FAU - John, Rosalind M
AU  - John RM
AD  - School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom.
LA  - eng
GR  - MR/M013960/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220909
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 9035-54-5 (Placental Lactogen)
SB  - IM
MH  - Birth Weight
MH  - *Cesarean Section
MH  - Female
MH  - Health Behavior
MH  - Humans
MH  - Placenta
MH  - *Placental Lactogen
MH  - Pregnancy
PMC - PMC9500170
OTO - NOTNLM
OT  - birth weight
OT  - body mass index
OT  - health-conscious diet
OT  - maternal depression
OT  - placental lactogen
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/09/27 06:00
MHDA- 2022/09/28 06:00
PMCR- 2022/01/01
CRDT- 2022/09/26 17:09
PHST- 2022/05/17 00:00 [received]
PHST- 2022/08/24 00:00 [accepted]
PHST- 2022/09/26 17:09 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/28 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.946539 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Sep 9;13:946539. doi: 
      10.3389/fendo.2022.946539. eCollection 2022.