PMID- 36157628
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 2163-0402 (Print)
IS  - 2163-0933 (Electronic)
IS  - 2163-0402 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Feb
TI  - Skin Autoimmunity Secondary to Alemtuzumab in a Tertiary Care Spanish Hospital.
PG  - 29-35
LID - 10.1212/CPJ.0000000000001126 [doi]
AB  - BACKGROUND AND OBJECTIVES: The most common adverse events (AEs) after alemtuzumab 
      (ALZ) include adverse infusion reactions, infections, and autoimmune disorders. 
      Skin AEs are common during infusion, but there are few reported cases of 
      long-term skin autoimmune disease. METHODS: A retrospective case series of 
      patients developing long-term autoimmune skin disorders after ALZ administration 
      in a tertiary care hospital. RESULTS: Of 133 patients treated with ALZ, 8 
      patients (6.02%) developed 9 autoimmune cutaneous AEs, including 4 events of 
      alopecia areata, 2 of vitiligo, 2 of chronic urticaria, and 1 of inflammatory 
      atrichia. Three of them occurred between the first and the second infusion. 
      DISCUSSION: The lesions described are secondary to autoimmune disorders, probably 
      related to immune dysregulation because of a differential lymphocyte repopulation 
      after ALZ. Autoimmune cutaneous AEs may be frequent, and it would be recommended 
      to monitor its appearance to treat them.
CI  - (c) 2021 American Academy of Neurology.
FAU - Lopez Ruiz, Rocio
AU  - Lopez Ruiz R
AUID- ORCID: 0000-0002-6807-0836
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Sanchez Fernandez, Felix
AU  - Sanchez Fernandez F
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Ruiz de Arcos, Maria
AU  - Ruiz de Arcos M
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Dotor Garcia-Soto, Julio
AU  - Dotor Garcia-Soto J
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Fuerte Hortigon, Alejandro
AU  - Fuerte Hortigon A
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Navarro Mascarell, Guillermo
AU  - Navarro Mascarell G
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Ruiz Pena, Juan Luis
AU  - Ruiz Pena JL
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Paramo Camino, M Dolores
AU  - Paramo Camino MD
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Guerra Hiraldo, Juan Diego
AU  - Guerra Hiraldo JD
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
FAU - Eichau, Sara
AU  - Eichau S
AD  - Unidad de Esclerosis Multiple, Hospital Universitario Virgen Macarena, Sevilla, 
      Espana.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Neurol Clin Pract
JT  - Neurology. Clinical practice
JID - 101577149
PMC - PMC9491501
EDAT- 2022/09/27 06:00
MHDA- 2022/09/27 06:01
PMCR- 2023/02/01
CRDT- 2022/09/26 17:11
PHST- 2021/03/01 00:00 [received]
PHST- 2021/06/15 00:00 [accepted]
PHST- 2022/09/26 17:11 [entrez]
PHST- 2022/09/27 06:00 [pubmed]
PHST- 2022/09/27 06:01 [medline]
PHST- 2023/02/01 00:00 [pmc-release]
AID - NEURCLINPRACT2021069372 [pii]
AID - 10.1212/CPJ.0000000000001126 [doi]
PST - ppublish
SO  - Neurol Clin Pract. 2022 Feb;12(1):29-35. doi: 10.1212/CPJ.0000000000001126.