PMID- 36158632 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220928 IS - 1948-5190 (Print) IS - 1948-5190 (Electronic) VI - 14 IP - 8 DP - 2022 Aug 16 TI - Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions. PG - 487-494 LID - 10.4253/wjge.v14.i8.487 [doi] AB - BACKGROUND: Endoscopic ultrasound (EUS)-guided main pancreatic duct (PD) access may be used when conventional endoscopic retrograde cholangiopancreatography (ERCP) techniques fail. The use of a percutaneous transluminal angioplasty balloon (PTAB), originally developed for vascular interventions, can be used to facilitate transmural (e.g., transgastric) PD access and to dilate high-grade pancreatic strictures. AIM: To describe the technique, efficacy, and safety of PTABs for EUS-guided PD interventions. METHODS: Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply database. PTABs included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch guidewire. The primary outcome was technical success. Secondary outcomes included incidence of adverse events (AEs) and need for early reintervention. RESULTS: A total of 23 patients were identified (48% female, mean age 55.8 years). Chronic pancreatitis was the underlying etiology in 13 (56.5%) patients, surgically altered anatomy (SAA) with stricture in 7 (30.4%), and SAA with post-operative leak in 3 (13.0%). Technical success was achieved in 20 (87%) cases. Overall AE rate was 26% (n = 6). All AEs were mild and included 1 pancreatic duct leak, 2 cases of post-procedure pancreatitis, and 3 admissions for post-procedural pain. No patients required early re-intervention. CONCLUSION: EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails. CI - (c)The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - AbiMansour, Jad P AU - AbiMansour JP AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Abu Dayyeh, Barham K AU - Abu Dayyeh BK AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Levy, Michael J AU - Levy MJ AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Storm, Andrew C AU - Storm AC AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Martin, John A AU - Martin JA AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Petersen, Bret T AU - Petersen BT AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Law, Ryan J AU - Law RJ AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Topazian, Mark D AU - Topazian MD AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. FAU - Chandrasekhara, Vinay AU - Chandrasekhara V AD - Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, United States. chandrasekhara.vinay@mayo.edu. LA - eng PT - Journal Article PL - United States TA - World J Gastrointest Endosc JT - World journal of gastrointestinal endoscopy JID - 101532474 PMC - PMC9453307 OTO - NOTNLM OT - Anastomotic stricture OT - Chronic pancreatitis OT - Dilating balloon OT - Pancreatic duct intervention COIS- Conflict-of-interest statement: Andrew C Storm is a consultant for Apollo Endosurgery; and received research support from Apollo Endosurgery and Boston Scientific. Ryan J Law is a consultant for ConMed and Medtronic and receives royalties from UpToDate. Bret T Petersen is a consultant for Olympus America and investigator for Boston Scientific and Ambu. Barham K Abu Dayyeh reports consultant roles with Endogenex, Endo-TAGSS, Metamodix, and BFKW; consultant and grant or research support from USGI, Cairn Diagnostics, Aspire Bariatrics, Boston Scientific; speaker roles with Olympus, Johnson and Johnson; speaker and grant or research support from Medtronic, Endogastric solutions; and research support from Apollo Endosurgery and Spatz Medical. Vinay Chandrasekhara is a consultant for Covidien LP, is on the advisory board for Interpace Diagnostics, and is a shareholder in Nevakar, Inc. The remaining authors have no conflicts or funding to disclose. EDAT- 2022/09/27 06:00 MHDA- 2022/09/27 06:01 PMCR- 2022/08/16 CRDT- 2022/09/26 17:23 PHST- 2022/02/14 00:00 [received] PHST- 2022/04/19 00:00 [revised] PHST- 2022/07/22 00:00 [accepted] PHST- 2022/09/26 17:23 [entrez] PHST- 2022/09/27 06:00 [pubmed] PHST- 2022/09/27 06:01 [medline] PHST- 2022/08/16 00:00 [pmc-release] AID - 10.4253/wjge.v14.i8.487 [doi] PST - ppublish SO - World J Gastrointest Endosc. 2022 Aug 16;14(8):487-494. doi: 10.4253/wjge.v14.i8.487.